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Compound pharmaceutical composition containing desloratadine citrate disodium and dimemorfan phosphate

A technique of dimethylorphane phosphate and its composition, which is applied in the field of medicine, can solve the problems of easy addiction to pseudoephedrine, unsuitable driving, low curative effect and side effects, and achieve the effects of no constipation side effects, less adverse reactions, and good curative effect

Inactive Publication Date: 2014-08-27
HEFEI IND PHARMA INST CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chlorpheniramine maleate has obvious central inhibitory effect. It is not suitable to drive a vehicle or perform highly concentrated work during the medication period. Pseudoephedrine is easy to become addicted. Therefore, it is urgent to develop anti-cold compound drugs with better curative effect and lower side effects in clinical practice.

Method used

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  • Compound pharmaceutical composition containing desloratadine citrate disodium and dimemorfan phosphate
  • Compound pharmaceutical composition containing desloratadine citrate disodium and dimemorfan phosphate
  • Compound pharmaceutical composition containing desloratadine citrate disodium and dimemorfan phosphate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Desloratadine Citrate+Dimethorphin Phosphate+Acetaminophen Granules (according to 1000 bags)

[0044] components

Dosage

desloratadine citrate

8.8g

Dimethyphane Phosphate

10.0g

Acetaminophen

200.0g

lactose

189.0g

aspartame

20.0g

Carmine

0.02g

Magnesium stearate

1g

essence

4g

[0045] Preparation:

[0046] Pass desloratadine citrate, dimethylorphane phosphate, acetaminophen, lactose, and aspartame through a 80-mesh sieve, mix well, dissolve carmine in water, make a soft material, and granulate with a 20-mesh sieve , dried, granulated through a 18-mesh sieve, added essence and magnesium stearate, mixed evenly, and then divided into bags.

Embodiment 2

[0048] Desloratadine Citrate+Dimethorphine Phosphate+Acetaminophen Tablets (Based on 1000 tablets)

[0049] components

Dosage

desloratadine citrate

17.6g

Dimethyphane Phosphate

10.0g

Acetaminophen

200.0g

microcrystalline cellulose

189.0g

aspartame

20.0g

Carmine

0.02g

Magnesium stearate

1.0g

essence

4.0g

[0050] Preparation:

[0051] Pass desloratadine citrate, dimethylmorphan phosphate, acetaminophen, microcrystalline cellulose, and aspartame through 80-mesh sieve respectively, mix well, dissolve carmine in water, and make soft material, 20-mesh Sieve and granulate, dry, granulate with 18-mesh sieve, add essence and magnesium stearate, mix evenly, and press into tablets.

Embodiment 3

[0053] Desloratadine citrate + dimethylorphine phosphate + acetaminophen solution (according to 1000 bottles)

[0054] components

Dosage

desloratadine citrate

35.2g

Dimethyphane Phosphate

30.0g

Acetaminophen

200.0g

sodium benzoate

3.0g

aspartame

20.0g

sodium bisulfite

2.0g

essence

4.0g

water

10000ml

[0055] Preparation:

[0056] Dissolve desloratadine citrate, dimethylorphane phosphate, and acetaminophen in an appropriate amount of water, heat and stir to dissolve, add sodium benzoate, aspartame, sodium bisulfite and essence, filter and add water to the prescribed amount , stir well and divide into packages.

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Abstract

The invention relates to the field of medicines, and in particular relates to a compound pharmaceutical composition containing desloratadine citrate disodium, dimemorfan phosphate and acetaminophen and a preparation method of the compound pharmaceutical composition. Found from harmacodynamic experiments, by means of drug combination of the three components, the synergy effect is shown; the compound pharmaceutical composition disclosed by the invention can be used for clinically treating cold.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a compound pharmaceutical composition containing desloratadine citrate, dimethylmorphan phosphate and acetaminophen and a preparation method thereof. Background technique [0002] Flu is generally caused by respiratory viruses or bacteria, and can fall ill throughout the year, especially in winter and spring, which is a common frequently-occurring disease. Children, the elderly, those with malnutrition, weak constitution, pregnant women, fatigue and those with disordered life patterns are susceptible groups. Clinical manifestations are characterized by nasal congestion, cough, headache, and general malaise. [0003] Due to the rapid onset of colds and complex and diverse symptoms, generally symptomatic treatment is mainly used to relieve various discomfort symptoms caused by colds. To the treatment of cold, there is no medicine so far that can solve all problems, and compound preparatio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/485A61P11/00A61K31/4545A61K31/167
Inventor 刘为中何广卫陈娟
Owner HEFEI IND PHARMA INST CO LTD
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