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Loading device and method for pressure stress of skeletal cells in porous titanium alloy

A loading device, titanium alloy technology, applied in tissue cell/virus culture device, stress-stimulated microbial growth method, bone/connective tissue cells, etc., can solve problems such as failure to achieve osseointegration, improve accuracy, and operate Simple, improved stability and reproducible effects

Inactive Publication Date: 2014-08-20
FOURTH MILITARY MEDICAL UNIVERSITY
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Problems solved by technology

However, in animal experiments, it was found that bone tissue grows better on the surface of porous materials, but it is difficult to completely grow into the interior of large-volume porous titanium alloy materials; at the level of trabecular bone, bone tissue and titanium alloy materials cannot achieve complete growth. Osseointegration

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  • Loading device and method for pressure stress of skeletal cells in porous titanium alloy
  • Loading device and method for pressure stress of skeletal cells in porous titanium alloy
  • Loading device and method for pressure stress of skeletal cells in porous titanium alloy

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Embodiment Construction

[0023] The present invention will be described in further detail below in conjunction with the accompanying drawings and specific examples.

[0024] Such as figure 1 As shown, the loading device for bone cell compressive stress in the porous titanium alloy of the present invention includes a rectangular pressurized chamber 4, and a detachable movable wall plate 5 is provided on the front side thereof, which can facilitate the taking and placing of cell culture vessels. The pressurized chamber is communicated with a cylindrical action chamber 2, wherein an action piston 3 is arranged, and a transmission rod 6 is connected above the action piston, and the transmission rod is connected to the rotating shaft of the servo motor 1 through a gear. The servo motor adopts MCAC706-N all-digital AC servo motor, controlled by the PC-based LabVIEW software through the motion control card DMC1380 ( figure 2 ) to control the AC servo motor to ensure accurate motion control. The AC servo m...

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Abstract

The invention discloses a loading device and method for pressure stress of skeletal cells in porous titanium alloy. The loading device comprises a servo motor, an acting chamber, an acting piston, a pressurizing chamber, a movable wallboard, a driving rod, a pressure sensor, a temperature sensor and the like, wherein the servo motor is controlled by a movement control card of a PC (Personal Computer) and is connected with the driving rod; the driving rod is connected with the acting piston; the servo motor drives the piston through the driving rod so as to vertically move. The front side wall of the pressurizing chamber is provided with the openable and closable movable wallboard. The device is placed in a cell incubator after being sterilized and disinfected, a skeletal cell suspension is planted in porous titanium alloy, and a pressurizing system is used for carrying out compressive load stimulation cells in the porous titanium alloy. When the system works, a pressure signal, a temperature signal and other signals respectively acquired by the pressure sensor, the temperature sensor and a humidity sensor in real time are transmitted to a data acquisition card and are displayed and stored on a display in real time through a PC terminal.

Description

technical field [0001] The invention relates to a device for loading compressive stress on bone cells in a porous titanium alloy and a method for loading compressive stress, so as to achieve the effect on bone cells (including osteoblasts, osteoclasts and bone cells) cultivated in vitro on the surface of porous titanium alloys. Cells) to apply stress load stimulation, and further study the mechanobiological signal transduction of these bone cells, to provide a scientific theoretical basis for the treatment of clinical bone defects by stress load and porous titanium alloy. Background technique [0002] The repair and functional reconstruction of bone defects are common and refractory diseases in orthopedic clinics, among which the repair of large bone defects in long bones is the most difficult. There are more than 15 million patients with limb insecurity in my country, of which about 3 million have amputated due to lack of reconstructive surgery and materials; about 3.5 mill...

Claims

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Application Information

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IPC IPC(8): C12M3/00C12N5/077
CPCC12M25/06C12M35/04C12M41/12C12M41/40C12N5/0658C12N2527/00C12N2533/20
Inventor 景达罗二平刘戈佟世超翟明明申广浩
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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