Pharmaceutical composition used for preventing and treating diabetes mellitus combined with hypertension

A composition and high blood pressure technology, applied in the field of medicine, can solve the problems of drug accumulation, increased adverse reactions, increased dosage, etc., and achieve the effects of lowering blood pressure, improving kidney function, and lowering blood sugar

Inactive Publication Date: 2014-08-20
QINGDAO MUNICIPAL HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] For patients with diabetic nephropathy, ACEI and ARB are definitely the first choice of antihypertensive drugs, but in clinical practice, some patients with diabetic nephropathy and high blood pressure are often encountered, the antihypertensive effect is not good, and the drug will accumulate in the body when the dosage is increased situation, increased adverse reactions

Method used

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  • Pharmaceutical composition used for preventing and treating diabetes mellitus combined with hypertension
  • Pharmaceutical composition used for preventing and treating diabetes mellitus combined with hypertension
  • Pharmaceutical composition used for preventing and treating diabetes mellitus combined with hypertension

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Experimental material: plantago seed extract: plantain seed to remove sand and impurities, crush plantago seed into small particles, sieve, reflux extract with 4 times the volume of 70-75% ethanol for 4 times, concentrate the extract, and dry , to obtain the Semen Plantaginis extract, for subsequent use. Valsartan was purchased from Changzhou Siyao Pharmaceutical Co., Ltd., batch number 20130905.

[0022] Experimental grouping and medication: Male spontaneously hypertensive rats (SHR), weighing 230-260 g, 10 weeks old, provided by Beijing Weitong Lihua Experimental Animal Technology Co., Ltd. (production license number: SCXK (Beijing) 2014-0001) , the animals had free access to food and water, the room temperature was kept at 24±2°C, and they were adaptively fed for 1 week. Then streptozotocin (STZ, 55 mg / kg, purchased from Sigma Chemical Company, USA) was injected through the tail vein. After 72 hours, the blood glucose was measured to be ≥ 16.6 mmol / L. Diabetes was d...

Embodiment 1

[0048] According to methods known in the art to prepare composition tablets, each tablet contains the following ingredients:

[0049] compound composition tablet

[0050] 40 mg of valsartan, 20 mg of psyllium seed extract, and the rest of the pharmaceutical excipients are commonly used excipients for tablet preparation.

[0051] Preparation process: Prepared according to the conventional preparation process of photographic agent.

Embodiment 2

[0053] According to methods known in the art to prepare composition tablets, each tablet contains the following ingredients:

[0054] compound composition tablet

[0055] 40 mg of valsartan, 40 mg of psyllium seed extract, and the rest of the pharmaceutical excipients are commonly used excipients for tablet preparation.

[0056] Preparation process: Prepared according to the conventional preparation process of photographic agent.

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Abstract

The invention relates to a pharmaceutical composition used for preventing and treating diabetes mellitus combined with hypertension. The pharmaceutical composition comprises valsartan and plantain seed extract in a weight ratio of 1: 0.01-100, and a tablet, a capsule, a granule and the like can be prepared from the pharmaceutical composition. Through pharmacological research, it is found that the composition has an ideal effect on treatment of primary hypertension combined with diabetes mellitus, can substantially reduce the levels of blood pressure and blood sugar of rats, obviously improves renal functions and exerts unexpected technical effects.

Description

technical field [0001] The invention relates to a pharmaceutical composition containing valsartan and psyllium seed extract, and the application of the composition in the preparation of drugs for preventing and treating diabetes combined with hypertension, belonging to the technical field of medicine. Background technique [0002] Diabetes and hypertension are often called "sister diseases" in medicine, and the two can often exist at the same time. Epidemiological survey results show that about 70% to 80% of diabetic patients have hypertension. Such patients are very prone to cerebrovascular complications, as well as renal and retinopathy. The drug treatment and choice of antihypertensive drugs for diabetes complicated with hypertension are different from those of non-diabetic hypertension. Therefore, when patients with diabetes mellitus complicated with hypertension choose antihypertensive drug therapy, the impact of different antihypertensive drugs on metabolism should be...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/68A61P3/10A61P9/12A61K31/41
Inventor 高伦
Owner QINGDAO MUNICIPAL HOSPITAL
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