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Medicinal composition for treating pulmonary fibrosis, and preparation method and application thereof

A technology of pulmonary fibrosis and composition, which is applied in the field of pharmaceutical composition for treating pulmonary fibrosis and its preparation and application, can solve the problems of lack of satisfactory prevention and treatment methods of western medicine, avoid serious toxic and side effects, improve related indicators, reduce The effect of content

Inactive Publication Date: 2014-07-23
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Although pulmonary fibrosis is reversible in treatment, there is still a lack of satisfactory prevention and treatment methods of western medicine, which may be related to the multiple factors of pulmonary fibrosis, multiple targets of disease, and the diversity of pathological processes.

Method used

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  • Medicinal composition for treating pulmonary fibrosis, and preparation method and application thereof
  • Medicinal composition for treating pulmonary fibrosis, and preparation method and application thereof
  • Medicinal composition for treating pulmonary fibrosis, and preparation method and application thereof

Examples

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Effect test

Embodiment 1

[0025] The preparation of embodiment 1 pharmaceutical composition of the present invention

[0026] Take 36 grams of Rhodiola rosea, 18 grams of Panax notoginseng powder, 30 grams of salvia miltiorrhiza, and 30 grams of Radix Ophiopogon japonicus. Weigh each herbal flavor according to the amount, grind Panax notoginseng into very fine powder for later use, mix the remaining three medicines with sufficient amount of clean water, boil with strong fire, then change to low heat and boil for 10 to 15 minutes, boil 3 times, collect water and boil After the liquid is added, notoginseng powder is added to obtain a decoction.

Embodiment 2

[0027] The preparation of embodiment 2 pharmaceutical compositions of the present invention

[0028] Take 40 grams of Rhodiola rosea, 15 grams of Panax notoginseng powder, 25 grams of salvia miltiorrhiza, and 35 grams of Radix Ophiopogon japonicus. First extract twice with 70% v / v ethanol, combine the ethanol extract, decoct the dregs with water twice, and combine the water decoction. Concentrate the ethanol extract and water decoction respectively, mix them, add appropriate amount of dextrin and soluble starch, and granulate to obtain granules.

Embodiment 3

[0029] The preparation of embodiment 3 pharmaceutical composition of the present invention

[0030] Take 30 grams of Rhodiola rosea, 20 grams of Panax notoginseng powder, 35 grams of salvia miltiorrhiza, and 35 grams of Radix Ophiopogon japonicus. First extract twice with 70% v / v ethanol, combine the alcohol extracts, decoct the dregs with water twice, and combine the water decoctions. Concentrate the alcohol extract and water decoction respectively, mix them, add appropriate amount of dextrin and soluble starch, granulate and compress into tablets to obtain tablets.

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Abstract

The invention provides a medicinal composition for treating pulmonary fibrosis. The medicinal composition is prepared from the following raw medicinal materials in parts by weight: 30-40 parts of rhodiola rosea, 15-20 parts of panax notoginseng, 25-35 parts of salvia miltiorrhiza and 35-35 radix ophiopogonis. The invention also provides a preparation method and application of the medicinal composition. The medicinal composition can be used for effectively treating pulmonary fibrosis, improving related indexes of pulmonary fibrosis and reducing the contents of TGF-beta (transforming growth factor-beta) and TGF-beta 1 (transforming growth factor-beta 1) in liver tissues, so that the treatment effect of relieving the symptoms of pulmonary fibrosis to improve the survival quality can be achieved, the serious toxic and side effects of western chemical medicines can be avoided, and a new choice is provided for clinical administration.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating pulmonary fibrosis, a preparation method and application thereof. Background technique [0002] Pulmonary fibrosis (PF) is a disease that causes lung inflammation, persistent alveolar damage, and repeated destruction, repair, reconstruction, and excessive deposition of extracellular matrix, resulting in changes in normal lung tissue structure and loss of function. It is a common outcome of chronic lung diseases caused by various reasons, and is the main pathological basis of respiratory failure. Its regulation is an extremely important factor in its occurrence and development pathological mechanism. [0003] Pulmonary fibrosis belongs to a class of refractory major diseases that have attracted international attention. Domestic and foreign studies believe that: fibrosis is the root cause of chronic diseases that cannot be cured for a long time, and it is also the main cause of disabilit...

Claims

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Application Information

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IPC IPC(8): A61K36/8968A61P11/00
Inventor 李戎杨明余青李富红
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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