Novel lincomycin soluble powder and preparing method thereof

A lincomycin and soluble technology, applied in the field of lincomycin soluble powder and preparation thereof, can solve the problems of difficulty in mixing uniformly, affecting the use effect, low solubility of lincomycin and the like, and achieves a simple and easy preparation process , The effect of reducing labor burden and increasing solubility

Inactive Publication Date: 2014-07-23
QINGDAO VLAND BIOTECH INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there are mainly formulations such as lincomycin suspension and lincomycin premix in the market. After the drinking water is mixed, the solubility of lincomycin is very low, and the drug sediments, so that the animals cannot drink enough drug; the premix is ​​difficult to mix evenly due to the low dosage of lincomycin, which affects the use effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Weigh 200g of polyethylene glycol 4000 and heat to 80°C, stir until completely melted, add 100g of lincomycin, stir until uniformly dispersed, cool to 0°C to make it completely solidified, dry the mixture and crush it through a 40-mesh sieve, Subpackage to obtain lincomycin soluble powder.

Embodiment 2

[0015] Weigh 400g of polyethylene glycol 6000 and heat to 100°C, stir until completely melted, add 100g of lincomycin, stir until uniformly dispersed, cool to 0°C to make it completely solidified, dry the mixture and crush it through a 40-mesh sieve, Subpackage to obtain lincomycin soluble powder.

Embodiment 3

[0017] Weigh 500g of polyethylene glycol 8000 and heat to 100°C, stir until completely melted, add 100g of lincomycin, stir until uniformly dispersed, cool to 0°C to make it completely solidify, dry the mixture and crush it through a 40-mesh sieve, Subpackage to obtain lincomycin soluble powder.

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PUM

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Abstract

The invention relates to novel lincomycin soluble powder and a preparing method thereof. The lincomycin soluble powder is prepared by heating a solid dispersion carrier to 80-100 DEG C by adoption a solid dispersion technology until the carrier is in a melt state, adding lincomycin, stirring and mixing uniformly, cooling, smashing, and sieving. The solubility of the lincomycin is increased. The preparing method is simple and feasible and low in cost.

Description

technical field [0001] The invention relates to a lincomycin soluble powder and a preparation method thereof, belonging to the field of pharmaceutical preparations. Background technique [0002] Penicillins are still widely used clinically because of their high efficiency, low toxicity, and low price, including the following types. Natural penicillins: penicillin, etc. Enzyme-resistant penicillins: Mecillin, etc. Broad-spectrum penicillins: lincomycin, etc. Uride penicillins: piperacillin, etc. [0003] At present, there are mainly dosage forms such as lincomycin suspensions and lincomycin premixes on the market. The main problem of suspension products is that after mixing with drinking water, the solubility of lincomycin is very low, and the drug occurs. Due to the sedimentation, the animals cannot receive enough medicine; the premix is ​​difficult to mix evenly due to the low dosage of lincomycin, which affects the use effect. Contents of the invention [0004] The...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K31/7056A61K47/34A61P31/04
Inventor 张瑞丽郝智慧赵永达
Owner QINGDAO VLAND BIOTECH INC
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