New use of pharmaceutical composition

A composition and drug technology, applied in the field of medicine, to achieve the effects of improving perimenopausal symptoms, improving reproductive organ atrophy, and improving gynecological endocrine function

Inactive Publication Date: 2014-07-16
BEIJING ACTING PHARMA BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0020] In the prior art, the pharmaceutical composition with the main raw materials of Radix Polygoni Multiflori, Dihuang, Cistanche, Dipsacus, Sangji, Uncaria, Cuscuta, Stir-fried Atractylodes Rhizoma Atractylodes Rhizome, Scutellaria baicalensis and Radix Paeoniae Alba has been proved by animal function tests: its effect on oxytocin The induced abortion of rats has obvious fetal protection effect, has obvious inhibitory effect on the contraction of isolated uterine smooth muscle in pregnant rats and normal rats, and can obviously resist the strong contraction of uterine smooth muscle caused by oxytocin, and has a good effect on intrauterine fetal growth retardation. Animal models have a significant protective effect; so far there have been no reports of its use in the treatment of decreased ovarian reserve and thin endometrium

Method used

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  • New use of pharmaceutical composition
  • New use of pharmaceutical composition

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] The pill preparation of embodiment 1 pharmaceutical composition

[0036] Recipe: Polygonum multiflorum 75g, Dihuang 75g, Cistanche 75g, Dipsacus 75g, Sangji 75g, Uncaria 75g, Cuscuta 150g, Stir-fried Atractylodes macrocephala 75g, Scutellaria baicalensis 75g and Paeoniae Alba 75g;

[0037] Preparation according to the above formula: crush each raw material into fine powder, sieve, and mix well, use 100-130g of refined honey for every 100g of powder to make small honey pills, 60 Co radiation sterilization.

Embodiment 2

[0038] The capsule preparation of embodiment 2 pharmaceutical compositions

[0039] Recipe: Polygonum multiflorum 80g, Rehmannia glutinosa 85g, Cistanche 80g, Dipsacus 75g, Mulberry 85g, Uncaria 65g, Cuscuta 170g, Stir-fried Atractylodes macrocephala 75g, Scutellaria baicalensis 75g and Radix Paeoniae Alba 80g;

[0040] Preparation according to the above formula: take dodder and crush it, add 70% ethanol to heat and reflux to extract twice, filter, combine the filtrate, recover ethanol under reduced pressure, concentrate to a relative density of 1.05-1.10 for later use; Filter, combine the filtrates and concentrate to a relative density of 1.05 to 1.15, add 95% ethanol to make the alcohol content reach 50%, let stand for 16 hours, filter, recover the ethanol from the filtrate, concentrate to a relative density of 1.05 to 1.20, and mix with the above-mentioned Cuscuta Combine the extracts, add maltodextrin, and spray dry to obtain dry extract powder, add magnesium stearate, gra...

Embodiment 3

[0041] The tablet preparation of embodiment 3 pharmaceutical compositions

[0042] Recipe: Polygonum multiflorum 95g, Rehmannia glutinosa 95g, Cistanche 90g, Dipsacus 95g, Mulberry 96g, Uncaria 95g, Cuscuta 200g, Stir-fried Atractylodes macrocephala 100g, Scutellaria baicalensis 100g and Baishao 95g;

[0043] Preparation according to the above formula: take dodder and crush it, add 70% ethanol to heat and reflux to extract twice, filter, combine the filtrate, recover ethanol under reduced pressure, concentrate to a relative density of 1.05-1.10 for later use; Filter, combine the filtrates and concentrate to a relative density of 1.05 to 1.15, add 95% ethanol to make the alcohol content reach 50%, let stand for 16 hours, filter, recover the ethanol from the filtrate, concentrate to a relative density of 1.05 to 1.20, and mix with the above-mentioned Cuscuta Combine the extracts, add maltodextrin, mix, dry, granulate and tablet to obtain.

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Abstract

The invention discloses a new use of a pharmaceutical composition in preparation of medicines for treating diminished ovarian reserve function and / or promoting endometrial development, wherein the pharmaceutical composition adopts prepared polygonum multiflorum, radix rehmanniae, prepared cistanche, teasel root, loranthus parasiticus, rhynchophylla, dodder seed, fried atractylodes macrocephala koidz, scutellaria baicalensis and radix paeoniae alba as main raw materials. The pharmaceutical composition can be used for increasing the ovarian reserve function and promoting the endometrial development by perfecting the gynecologic endocrine function and increasing the endometrial thickness, and the pharmaceutical composition has broad prospect in clinical application.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of a pharmaceutical composition in the preparation of medicines for treating ovarian reserve function decline and / or promoting endometrium development. Background technique [0002] Decreased ovarian reserve is a transitional stage of premature ovarian failure, which refers to the weakened ability of the ovaries to produce eggs and the decline in follicle quality, leading to decreased female fertility and lack of sex hormones, also known as "ovarian aging". The clinical manifestations are less menstruation, thin menstruation, even amenorrhea, infertility, accompanied by different degrees of perimenopausal symptoms, such as hot flashes, hyperhidrosis, facial flushing, emotional instability, low libido, vaginal dryness, osteoporosis Wait. If it cannot be corrected in time, it may develop into premature ovarian failure. It is a gradual process from the decline of o...

Claims

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Application Information

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IPC IPC(8): A61K36/804A61P15/08A61P15/00A61K35/02A61K35/56A61K35/618
Inventor 程雪翔
Owner BEIJING ACTING PHARMA BIOTECH
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