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Application of lonicera caerulea anthocyanin extract in preparation of medicine and/or health care product for improving polycystic ovarian syndrome

An anthocyanin extract, polycystic ovary technology, applied in the preparation of sugar derivatives, drug combinations, medical preparations containing active ingredients, etc., can solve the problems of the impact on follicle development and the research on antioxidant effects that have not been reported. , to improve the antioxidant capacity of the ovary, improve the psychological and physiological treatment pressure, and improve the effect of ovarian reserve function

Pending Publication Date: 2022-04-12
THE SECOND HOSPITAL AFFILIATED TO WENZHOU MEDICAL COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there are many studies on anthocyanins. However, there are no reports on the effects of anthocyanins on follicle development and antioxidant effects in PCOS patients.

Method used

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  • Application of lonicera caerulea anthocyanin extract in preparation of medicine and/or health care product for improving polycystic ovarian syndrome
  • Application of lonicera caerulea anthocyanin extract in preparation of medicine and/or health care product for improving polycystic ovarian syndrome
  • Application of lonicera caerulea anthocyanin extract in preparation of medicine and/or health care product for improving polycystic ovarian syndrome

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] The present embodiment is a method for extracting anthocyanin extracts from edulis indica, the extraction method comprising:

[0034] (a) using DL-malic acid and citric acid to adjust the pH value of 75% ethanol aqueous solution to 3-4 to obtain an extract;

[0035] (b) Use the extract to extract the indigo pomace for 3 times, specifically, the first extraction: according to the mass volume ratio of the indigo pomace to the extract solution is 1:4, place the indigo pomace in the extract And stir for 4 hours, then filter with a 1000-mesh frame to collect the filtrate and filter residue;

[0036] The second extraction: according to the mass volume ratio of the indigo fruit pomace and the extract solution being 1:3, the filter residue was placed in the extract solution and stirred for 2 hours, and then filtered with a 1000-mesh frame to collect the filtrate and filter residue;

[0037] The third extraction: according to the mass-volume ratio of the indigo pomace and the e...

experiment example 1

[0045] The anthocyanin extracts obtained in the above-mentioned Example 1 and Comparative Examples 1-2 were subjected to ultraviolet-visible spectrum analysis, and the analysis method was as follows:

[0046] 1) Instruments and appliances: analytical balance, ultrasonic cleaner, UV-Vis spectrophotometer.

[0047] 2) Reagents and solutions: methanol, hydrochloric acid, 2% hydrochloric acid-methanol solution, pure water.

[0048] 3) Operation method

[0049] A. Preparation of the test solution

[0050]Accurately weigh 15-20 mg (accurate to 0.01 mg) of the test sample and put it into a flask, add 60 mL of 2% hydrochloric acid-methanol solution (m / V), reflux in a water bath at 80 ° C for 0.5 hours, cool to room temperature, and use 2 % Hydrochloric acid-methanol solution (m / V) was transferred completely and the volume was adjusted to 100mL, and shaken to obtain test solution A. Then accurately draw 5mL of test solution A into a 50mL volumetric flask, dilute to the mark with 2% ...

experiment example 2

[0077] Research on the influence of the anthocyanin extract obtained in Example 1 and Comparative Examples 1-2 on PCOS:

[0078] (1) Establishment and model verification of PCOS mouse model

[0079] 25-day-old C57BL / 6 female mice were continuously injected with DHEA (6mg / 100g, 0.2mL·d -1 Sesame oil dissolved) at the same time 60% high-fat feed was continuously fed for 20 days; the control group was fed normally; after the experiment, blood and bilateral ovaries were collected from each group of mice, one side was fixed for pathological detection, and the other side was used for follow-up detection; verification method as follows:

[0080] 1) Vaginal smears: Collect vaginal exfoliated cell smears from the 11th day of administration, for 10 consecutive days, collect vaginal exfoliated cells from mice at 5:00-6:00 pm every day for smear observation. (Normal group and model group were randomly selected 3).

[0081] 2) Pathology of polycystic ovary: HE staining, the method is as...

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Abstract

The invention discloses an application of a lonicera caerulea anthocyanin extract in preparation of a medicine and / or a health care product for improving polycystic ovarian syndrome. The lonicera caerulea anthocyanin extract disclosed by the invention has a remarkable effect on improving follicular retardation of PCOS mice, has the functions of improving ovarian reserve and improving ovarian oxidation resistance, brings good news to vast PCOS patients, and can improve psychological and physiological treatment pressure of the PCOS patients and reproductive health of vast infertility patients; the fertility potential of young women at the childbearing age is improved.

Description

technical field [0001] The present invention relates to the technical field of treating polycystic ovary syndrome, in particular to the application of anthocyanin extract from Cystaceae in the preparation of medicines and / or health care products for improving polycystic ovary syndrome. Background technique [0002] Polycystic ovary syndrome (PCOS) is the most common reproductive system disease in gynecological endocrinology. Its main symptoms are amenorrhea, infertility, easy miscarriage after pregnancy, obesity, hirsutism and other masculine signs. It currently affects about 5%-10% of the world. Menstruation and childbearing of women of childbearing age are also closely related to the health of offspring. In recent years, studies have found that the metabolic abnormalities of PCOS patients are mainly manifested in clinical manifestations such as glucose tolerance, abnormal blood lipid metabolism, and insulin resistance. PCOS is a genetic disease, but there are also some ot...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P15/00A61P15/08A61P39/06A61K36/355C07H17/065C07H1/08
Inventor 刘晓明陈放景卓刘九思赵军招
Owner THE SECOND HOSPITAL AFFILIATED TO WENZHOU MEDICAL COLLEGE
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