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Alprostadil combinatorial drug

A technology of alprostadil and medicine, applied in the field of combination medicine of alprostadil and preparation thereof, can solve the problems of increasing product storage cost and transportation cost, inconvenient storage and transportation, unstable preservation and the like, and achieves guaranteed bacteriostatic effect, The effect of preventing microbial contamination, ensuring stability and safety

Inactive Publication Date: 2014-07-09
邓学峰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, because alprostadil for injection is not stable in the greenhouse, it is easily damaged when exposed to external forces such as light, heat, water, oxidation, etc., which brings great inconvenience to storage and transportation, and also increases the storage cost of the product. and shipping costs

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] A kind of combination medicine of alprostadil of the present invention is made of the effective medicinal ingredients of following parts by weight:

[0025] Alprostadil 70

[0026] Vitamin C 20

[0027] Folic acid 5

[0028] Glycine 30

[0029] The method of described alprostadil combination medicine, its preparation method and steps are as follows:

[0030] (2). Take water for injection whose weight is 5-15 times of the weight of the alprostadil, and under stirring, dissolve the alprostadil, vitamin C, folic acid and glycine completely respectively to obtain the combined drug solution of alprostadil ;

[0031] (2). The medicinal solution obtained in step (1) is ultrafiltered with a molecular weight cut-off of 6000D ultrafiltration membrane, the filtrate is ultrafiltered with a membrane with a molecular weight cut-off of 2000D, and the filtrate is adjusted to a pH value of 6.1-6.5 with 8% hydrochloric acid solution;

[0032] (3). The liquid medicine obtained in...

Embodiment 2

[0038] A kind of combination medicine of alprostadil of the present invention is made of the effective medicinal ingredients of following parts by weight:

[0039] Alprostadil 85

[0040] Vitamin C 24

[0041] Folic Acid 8

[0042] Glycine 35

[0043] The method of described alprostadil combination medicine, its preparation method and steps are as follows:

[0044] (3). Take water for injection whose weight is 5-15 times of the weight of the alprostadil, and under stirring, dissolve the alprostadil, vitamin C, folic acid and glycine completely respectively to obtain the combined drug solution of alprostadil ;

[0045] (2). The medicinal solution obtained in step (1) is ultrafiltered with a molecular weight cut-off of 6000D ultrafiltration membrane, the filtrate is ultrafiltered with a membrane with a molecular weight cut-off of 2000D, and the filtrate is adjusted to a pH value of 6.1-6.5 with 8% hydrochloric acid solution;

[0046] (3). The liquid medicine obtained in...

Embodiment 3

[0052] A kind of combination medicine of alprostadil of the present invention is made of the effective medicinal ingredients of following parts by weight:

[0053] Alprostadil 96

[0054] Vitamin C 28

[0055] Folic Acid 12

[0056] Glycine 40

[0057] The method of described alprostadil combination medicine, its preparation method and steps are as follows:

[0058] (4). Take water for injection whose weight is 5-15 times of the weight of the alprostadil, and under stirring, dissolve the alprostadil, vitamin C, folic acid and glycine completely respectively to obtain the combined drug solution of alprostadil ;

[0059] (2). The medicinal solution obtained in step (1) is ultrafiltered with a molecular weight cut-off of 6000D ultrafiltration membrane, the filtrate is ultrafiltered with a membrane with a molecular weight cut-off of 2000D, and the filtrate is adjusted to a pH value of 6.1-6.5 with 8% hydrochloric acid solution;

[0060] (3). The liquid medicine obtained i...

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PUM

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Abstract

The invention provides an alprostadil combinatorial drug. The alprostadil combinatorial drug is characterized in that the alprostadil combinatorial drug is prepared from alprostadil, vitamin C, folic acid and glycine as active ingredients according to a weight part ratio of alprostadil, vitamin C, folic acid to glycine is 70-150: 20-35: 5-20: 30-60. The alprostadil combinatorial drug is superior to the drug prepared by the prior art in safety, stability and curative effects and can be prepared by an energy-saving and eco-friendly preparation method.

Description

technical field [0001] The invention relates to a combination medicine of alprostadil and a preparation method thereof. Background technique [0002] Alprostadil is a biologically active substance widely present in the body. The mechanism of treatment of diabetic neuropathy: 1. Improve hemodynamics, by increasing the CAMP content in vascular smooth muscle cells, exert its vasodilator effect and reduce peripheral resistance; 2. Improve Hemorheology, PGE1 can inhibit platelet aggregation, reduce platelet hyperreactivity and thromboxane A 2 (TXA 2) level, inhibit platelet activation, promote the reversal of activated platelets around thrombus, and improve the deformability of red blood cells; 3. PGE1 , can activate lipoproteinase and promote triglyceride hydrolysis, reduce blood lipid and blood viscosity; 4, PGE1, can stimulate vascular endothelial cells to produce tissue-type fibrinolytic substance (t-PA), has a certain direct thrombolytic effect. 5. By inhibiting the free Ca...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/22A61K47/18A61K31/5575A61P9/14A61P9/10A61P17/02A61P29/00A61P7/02A61P1/16
Inventor 邓学峰
Owner 邓学峰
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