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Biological tissue simulating object and preparation method thereof

A technology of biological tissues and simulants, which is applied in the direction of measuring devices, instruments, and mechanical devices, can solve the problems of insufficient reliability and stability of test results, difficult acquisition of animal tissues, and inconvenient storage, etc., to achieve abundant raw materials, Screening and Testing Perfect Effects

Inactive Publication Date: 2014-07-02
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The technical problem to be solved by the present invention is that animal body tissues are not easy to obtain, inconvenient to store, varying degrees of freshness, and the processing process is cumbersome, which makes the operation process of the adhesion test complicated, and the reliability and stability of the test results are not good enough, thus affecting the quality of human body tissue. Screening and optimization of adhesion materials, in order to overcome the above deficiencies, a biological tissue mimic and its preparation method are provided

Method used

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  • Biological tissue simulating object and preparation method thereof
  • Biological tissue simulating object and preparation method thereof
  • Biological tissue simulating object and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Biological tissue: pig liver

[0041] It is determined that the biological tissue simulant A includes gelatin, PEO and water, the water content is 15%, and the weight of PEO is 25% of the weight of gelatin.

[0042] Weigh 20 grams of gelatin and 5 grams of PEO, and add them into water at 50°C for compounding. The weight of water is 3 times that of gelatin.

[0043] The compound mixture was dried in a constant temperature and humidity box for 16 hours, the temperature was controlled at 20°C, and the relative humidity was controlled at 35%. After drying into a film, a biological tissue mimic A with a thickness of 0.2mm was obtained. The moisture content is 15%.

Embodiment 2

[0045] Biological tissue: inner epidermis of pork belly

[0046] It is determined that the biological tissue simulant B includes gelatin, HPC and water, the water content is 30%, and the weight of HPC is 15% of the weight of gelatin.

[0047]Weigh 20 grams of gelatin and 3 grams of HPC, and add them into water at 50°C for reconstitution. The weight of water is 8 times that of gelatin.

[0048] The compound mixture was dried in a constant temperature and humidity box for 8 hours, the temperature was controlled at 30°C, and the relative humidity was controlled at 50%. After drying into a film, a biological tissue mimic B with a thickness of 0.1mm was obtained. The moisture content is 30%.

Embodiment 3

[0050] Biological tissue: outer skin of pork belly

[0051] It is determined that the biological tissue simulant C includes gelatin, PEO and water, the water content is 20%, and the weight of PEO is 15% of the weight of gelatin.

[0052] Weigh 30 grams of gelatin and 4.5 grams of PEO, and add them into water at 50°C for compounding. The weight of water is 2.5 times that of gelatin.

[0053] The compound mixture was dried in a constant temperature and humidity box for 12 hours, the temperature was controlled at 25°C, and the relative humidity was controlled at 40%. After drying into a film, a biological tissue mimic C with a thickness of 0.4mm was obtained. The moisture content is 20%.

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Abstract

The invention belongs to the technical field of testing on the adhesion performance between an adhesive material and biological tissue in vitro and in particular relates to a biological tissue simulating object in the performance test and a preparation method thereof. The biological tissue simulating object comprises gelatin, an adhesion regulator and water, the moisture content of the biological tissue simulating object is 5%-40% and the weight of the adhesion regulator is 0-50% of that of the gelatin. The preparation method comprises the following steps: determining components and ratios, compounding and drying to form a membrane. The biological tissue simulating object provided by the invention is used as an adhered matrix, a simple and reliable vertical adhesion test device is constructed through a lever of a physical balance, and the problems that biological tissue is difficult to obtain, inconvenient to store, different in fresh degree, relatively tedious in treatment process and poor in test stability are overcome; therefore, the biological tissue simulating object for testing the adhesion performance in vitro is constructed, so that the screening and testing of an adhesion material is perfect.

Description

technical field [0001] The invention belongs to the technical field of testing the adhesion performance between an adhesive material and a biological tissue in vitro, and in particular relates to a biological tissue simulant in performance testing and a preparation method thereof. Background technique [0002] Bioadhesive performance refers to the ability of adhesive materials to adhere to biological mucous membranes produced by the interaction between adhesive materials and biological mucus or tissue mucosal surfaces, which is achieved through multiple interactions between adhesive materials and adherent tissues, including electrostatic Interaction, hydrogen bond, van der Waals force, hydrophilic / hydrophobic interaction, mechanical interpenetration and entanglement between molecular segments, etc. Bioadhesion studies of adherent materials can be evaluated in vitro and in vivo. The biological tissue used in the in vitro bioadhesion test method is mainly obtained by processi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N19/04
Inventor 纪晓寰孙宾吴国华张新林王婧奇朱美芳
Owner DONGHUA UNIV
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