A small animal multispectral fluorescence tomography system excited by narrow-beam x-rays

Abstract

The invention discloses a small animal multispectral fluorescence tomography system excited by narrow-beam X-ray and relates to the technical field of biomedicine images. The back portion of an X-ray constraint machine is provided with a fixing device. An animal bed is arranged in the fixing device. Reflecting devices are arranged on the two sides of the animal bed. An EMCCD camera is vertically arranged right above the animal bed. A smoothing wheel is arranged between the EMCCD camera and the animal bed. The smoothing wheel is provided with a plurality of circular holes evenly. Narrow-beam smoothing pieces are arranged in the circular holes. A stepping motor is arranged on one side of the fixing device. The stepping motor is connected with the animal bed. The back end of the fixing device is provided with an X-ray detector. Fluorescence materials in an object to be imaged are excited through the narrow-beam X-ray, accordingly, fluorescence signals of the surface of the object to be imaged and X-ray signals which penetrate through the object to be imaged are obtained, two kinds of obtained imaging information are subjected to reestablishing and fusion, and accordingly multi-model imaging is achieved.

Description

Technical field: [0001] The invention relates to a small animal multi-spectrum fluorescence tomographic imaging system excited by narrow-beam X-rays, belonging to the technical field of biomedical imaging. Background technique: [0002] At present, the narrow-beam X-ray excited fluorescence tomography system uses narrow-beam X-rays to irradiate the object to be imaged. The X-ray structural imaging and fluorescence imaging of the object to be imaged are reconstructed, and the two images are fused to obtain multi-modal imaging. [0003] In 2010, Stanford University proposed a new imaging modality—X-ray excited tomography. A narrow beam of X-rays is used to irradiate the object, and a highly sensitive photoelectric detection device is used to receive the fluorescent signal emitted from the tissue on the other side. In the same year, the research group published a tomographic imaging system with narrow-beam X-ray excitation and luminescence. Based on the cone-beam CT system, t...

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Problems solved by technology

In the same year, the research group published a tomographic imaging system with narrow-beam X-ray excitation and luminescence. Based on the cone-beam CT system, two lead plates were used to form a 1mm gap to form narrow-beam X-rays, and a high-sensitivity CCD camera was used to receive fluorescence. signal, this system can complete simple and regular body simulation experiments, and can get more accurate experimental results. The system adopts the "translation-rotation" method, and the simulation needs to scan 26 times at each angle and rotate 24 times to complete the whole During the scanning process, the scanning time is long, the collected fluorescence signal is single-spectrum, the information used for fluorescence reconstruction is not rich enough, and the reconstructed effect is not accurate enough

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