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Method of resisting breeding of female rats by sophoricoside

An anti-fertility, sophoridin technology, applied in the field of female sterility agents, can solve the problems of anti-fertility mechanism and application that have not been reported

Inactive Publication Date: 2014-06-18
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] So far, only literature has reported that sophorin has anti-fertility effects on experimental animals, but there has been no report on its specific anti-fertility mechanism and application.

Method used

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  • Method of resisting breeding of female rats by sophoricoside
  • Method of resisting breeding of female rats by sophoricoside
  • Method of resisting breeding of female rats by sophoricoside

Examples

Experimental program
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Effect test

example 1

[0036] Sophorin with a purity of 98% was selected as the infertility drug, and ICR female mice on the first day of conception were used as the research object, and the dose of 150mg / kg / day was administered orally for 5 consecutive days, and the average embryo implantation was found The number was reduced by up to 20% compared with the control group.

example 2

[0038] Sophoridoside with a purity of 98% was selected as the infertility drug, and the ICR female mice on the first day of conception were taken as the research object, and the dose of 300mg / kg / day was administered orally for 5 days continuously, and the average embryo implantation was found The number was reduced by more than 30% compared to the control group.

example 3

[0040] Sophoridoside with a purity of 98% was selected as the infertility drug, and ICR female mice on the first day of conception were taken as the research object, and the dose of 600mg / kg / day was administered orally for 5 days continuously, and the average embryo implantation was found Compared with the control group, the number decreased by 70%, which was statistically significant (P<0.05). Pathological studies found that after treatment with sophoridoside, the pathological hyperplasia and thickness of the endometrium increased, the structure of the endometrium changed, and the expression level of ERα, a key receptor affecting embryo implantation in the uterus, was significantly reduced (P<0.05), PR The expression level of was significantly increased (P<0.05). The result of the experiment is that the infertility rate can reach 70%.

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Abstract

The invention relates to a rodenticide resisting breeding of female rats by taking sophoricoside as an active ingredient, belonging to the technical fields of biological prevention and control. The damage caused by rats is always a serious disaster problem in the world, which causes damage to agriculture, forestry and animal husbandry, seriously damages ecological environment and threatens human health. Through the years, people use multiple methods to control the population quantity of rats, and a method for controlling the population quantity of the rats by a breeding-resisting technique is a new technique developed in recent years. The invention relates to the rodenticide resisting breeding of female rats by taking sophoricoside as an active ingredient, which is used for controlling the murine reproduction. Compared with a traditional ecological deratization method and chemical poison bait method, the breeding resisting method has long effective time, obvious control effect, small toxic and side effects on the environment and the like, and can more effectively inhibit the super compensatory effect of rat population. If the rodenticide resisting breeding of female rats provided by the invention can be applied to the production of agriculture, forestry and animal husbandry, the rat population can be effectively controlled and the wide economic benefit can be achieved.

Description

technical field [0001] The invention relates to an anti-fertility rodenticide for controlling rodent damage, in particular to a female sterile agent with sophorin as an active ingredient for controlling rodent reproduction. Background technique [0002] Rodent infestation has always been a serious worldwide disaster. While causing damage to agriculture, forestry and animal husbandry, it also seriously damages the ecological environment and threatens human health. There are more than 2,000 species of rodents in the world, and 130 species of rodents have been recorded in my country, including 112 species of agricultural pests. [0003] Rodent is also the first of the "three pests" on grasslands in my country, and is the main biological disaster in grasslands. As an important factor in the degradation of grassland ecosystems, it is seriously threatening the existence and development of grassland animal husbandry. The total area of ​​grassland in my country is nearly 6 billion ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N43/16A01P23/00A01P11/00
Inventor 杨志荣张杰周建宏瞿成权赵建孙群冯甦侯若彤
Owner SICHUAN UNIV
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