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Enteric-coated hollow capsule production process

A production process and hollow capsule technology, which is applied in the production process of enteric-coated hollow capsules, can solve the problems of large capsule weight differences, fragile capsules, slow drying and molding, etc., and achieve stable product quality, small weight differences, and disintegration point accurate effect

Inactive Publication Date: 2014-05-21
九江昂泰胶囊有限公司
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  • Abstract
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AI Technical Summary

Problems solved by technology

Since the thickness of the coating layer is required to reach 2-3 microns according to the regulations, the process is cumbersome, the drying molding is slow, the thickness of the hollow capsule is uneven, the weight of the capsule varies greatly, and it is easy to disintegrate in the gastric juice, and the capsule is fragile. The qualified rate of the product is low when the powder is filled on the machine

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0011] This specific embodiment adopts the following technical scheme: add 200g of hypromellose phthalate to 2000ml of acetone, 40ml of ethanol and stir until completely dissolved, add 20ml of triethyl citrate, continue to stir until uniform, filter and store in an airtight container in spare. Pour 1kg of gelatin, 20g of sorbitol, and 2.5kg of hot water at 65°C into the reaction pot, turn on the mixer, and continue heating the insulation water in the interlayer of the reaction pot, so that the temperature of the glue reaches 75°C, and keep it warm for 2 hours. After the glue is completely melted, add Appropriate amount of food coloring and opacifying agent, then release the glue solution from the reaction pot and filter it into the insulation bucket, then add 250g of the enteric-coated auxiliary material into the insulation bucket according to the weight ratio of gelatin and enteric-coated auxiliary material liquid 1:0.25, and stir evenly , Cover the lid, and keep it warm for ...

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Abstract

The invention provides an enteric-coated hollow capsule production process, and relates to a hollow capsule production process. The production process comprises: adopting a pharmaceutical gelatin as a main material, adding a plasticizer and an enteric-coated auxiliary material after gelatin dissolving, loading the obtained gelatin liquid, drying, and carrying out cutting and nesting to prepare the enteric-coated hollow capsule in one time. According to the present invention, the complex process that the gastric-dissolved blank is firstly prepared and then the gastric juice blank is coated and demolded is reduced, and the produced product has characteristics of stable quality, uniform thickness, less weight difference, accurate disintegration point and high qualification rate, and meets requirements of the national pharmacopoeia on the enteric-coated hollow capsule.

Description

technical field [0001] The invention relates to a production process of hollow capsules, in particular to a production process of enteric-coated hollow capsules. Background technique [0002] At present, the production process of domestic enteric-coated hollow capsules is to first dip the blank of gastric-soluble capsules on the mold to form a skeleton layer, and then dip it once or twice in enteric-coating solution to form a coating layer. Since the thickness of the coating layer is required to reach 2-3 microns according to the regulations, the process is cumbersome, the drying molding is slow, the thickness of the hollow capsule is uneven, the weight of the capsule varies greatly, and it is easy to disintegrate in the gastric juice, and the capsule is fragile. When the powder is filled on the machine, the qualified rate of the product is low. Contents of the invention [0003] The purpose of the present invention is to provide a production process of enteric-coated hol...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48
Inventor 余樟
Owner 九江昂泰胶囊有限公司
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