Quick biological tissue optical characteristic parameter measurement method based on short-pulse laser reflection signal peak inversion

An optical characteristic parameter and short-pulse laser technology, which is applied in the field of biological tissue optical parameter measurement, can solve problems such as long measurement response time, and achieve the effect of faster measurement response time and faster time

Active Publication Date: 2014-05-07
HARBIN INST OF TECH
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Problems solved by technology

[0005] In order to solve the problem of long response time in measuring the optical parameters of the existing biological tissue, the present invention proposes a rapid

Method used

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  • Quick biological tissue optical characteristic parameter measurement method based on short-pulse laser reflection signal peak inversion
  • Quick biological tissue optical characteristic parameter measurement method based on short-pulse laser reflection signal peak inversion
  • Quick biological tissue optical characteristic parameter measurement method based on short-pulse laser reflection signal peak inversion

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specific Embodiment approach 1

[0036] Specific implementation mode 1. Combination figure 1 , figure 2 image 3 and Figure 4 Describe this embodiment, the rapid measurement method for the optical characteristic parameters of biological tissue based on the inversion of the peak value of the short-pulse laser reflection signal described in this embodiment, the specific steps of the method are:

[0037] Step 1. Make the biological tissue sample into a flat sample block with a thickness of L, and measure the peak value of the time-domain hemispherical reflection signal on the surface of the sample block The specific process is:

[0038] Firstly, the continuous laser light is incident on the surface of the biological tissue sample vertically, and the surface reflectance R of the sample tissue is measured by a single photon counter. ∞ , and then using a pulse width of t p Gaussian pulsed laser produced by Gaussian pulsed laser I c (t), perpendicular to the surface of the biological tissue sample, the time...

specific Embodiment approach 2

[0060] Specific embodiment 2. This embodiment is a further description of the rapid measurement method for the optical characteristic parameters of biological tissue based on the inversion of the peak value of the short-pulse laser reflection signal described in the specific embodiment 1. The inverse problem algorithm described in step 3 uses random Particle Swarm Algorithm.

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Abstract

The invention discloses a quick biological tissue optical characteristic parameter measurement method based on short-pulse laser reflection signal peak inversion and belongs to the technical field of biological tissue optical characteristic parameter measurement. The problem that the response time for the conventional biological tissue optical characteristic parameter measurement is long is solved. The method comprises the steps of measuring a peak value Rmax of a time domain semispherical reflection signal on the surface of a sample block to be measured, changing a pulse width tp of a laser device to obtain n groups of semispherical reflection signal peak values Rmax,i according to the former measuring method, setting the scattering albedo Omega of a sample to be measured and an asymmetric factor g of the sample to be measured, and obtaining undetermined coefficients a and b through an experience formula; obtaining estimated values Rmax,i of the n groups of semispherical reflection signal peak values, and performing least-square on estimated values Rmax,i of time domain semispherical reflection signal peak values and time domain semispherical reflection signals Rmax,i corresponding to the estimated values Rmax,i of the signal peak values to obtain a difference value; judging whether the least-square difference value is smaller than a threshold value Epsilon, if the least-square difference value is smaller than the threshold value Epsilon, implementing quick measurement on the biological tissue optical characteristic parameter based on the short-pulse laser reflection signal peak inversion, otherwise, continuing performing measurement. The quick biological tissue optical characteristic parameter measurement method is suitable for biological tissue optical characteristic parameter measurement.

Description

technical field [0001] The invention belongs to the technical field of biological tissue optical parameter measurement. Background technique [0002] For the measurement of optical parameters of biological tissues, it is of great significance to the construction and verification of biological heat transfer models, the study of thermal responses of biological tissues under the action of various heat sources, clinical medicine and physiology and other related fields. It is the basis for further research on the propagation of light in biological tissues, and has important guiding significance for clinical applications of lasers such as laser surgery and photodynamic therapy. The optical parameters of biological tissue are directly related to the composition, structure and health status of the tissue, and it plays an important role in the non-contact, non-destructive, fast and accurate detection of the optical parameters of the tissue. [0003] The scattering albedo and asymmet...

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Application Information

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IPC IPC(8): A61B5/00
Inventor 齐宏任亚涛陈琴张彪阮立明
Owner HARBIN INST OF TECH
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