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Bezafibrate dual-release slow-release capsule medicinal composition

A technology of bezafibrate and sustained-release capsules is applied in the field of dual-release sustained-release capsules and their preparation, and can solve the problems of uneven drug release, poor medication compliance, and low bioavailability.

Active Publication Date: 2014-04-09
天津梅花生物医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0031] In conventional preparation methods, bezafibrate is made into ordinary tablets or capsules, sustained-release tablets or capsules, all of which have low bioavailability, uneven drug release, and blood drug peaks in blood drug concentration, which increases drug resistance. Disadvantages such as the occurrence of drug properties and the risk of toxic and side effects, and poor compliance with medication

Method used

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  • Bezafibrate dual-release slow-release capsule medicinal composition
  • Bezafibrate dual-release slow-release capsule medicinal composition
  • Bezafibrate dual-release slow-release capsule medicinal composition

Examples

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Effect test

Embodiment 1

[0140] Every 1000 described bezafibrate pharmaceutical compositions, its formula consists of:

[0141] release immediately

[0142] Bezafibrate 100g

[0143] Polyvinylpyrrolidone K30 40g

[0144] Microcrystalline Cellulose 10g

[0145] slow release

[0146]

[0147]

[0148] Process steps:

[0149] 1) Preparation and processing of raw and auxiliary materials: prepare raw and auxiliary materials according to the prescription quantity, and meet the quality standards;

[0150] 2) Weighing: According to the prescription amount, double-checked to calculate the feeding amount, and weigh the above raw and auxiliary materials respectively;

[0151] 3) Mixing: mixing the prescribed amount of bezafibrate with each auxiliary material in the prescribed amount so as to fully mix them;

[0152] 4) Extrusion: Set the position of each head of the twin-screw extruder to 100°C-130°C-140°C-145°C, and the screw speed to 40r / min. Put the mixture into the hopper of the machine, and the ma...

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Abstract

The invention relates to a bezafibrate dual-release slow-release medicinal composition. The above dual-release capsule includes an immediate-release bezafibrate pellet and a slow-release bezafibrate pellet. The bezafibrate dual-release slow-release medicinal composition fills a gap in the market in China, and is convenient for clinical application.

Description

technical field [0001] The invention relates to a pharmaceutical composition of bezafibrate double-release sustained-release capsules, a double-release sustained-release capsule and a preparation method thereof. Background technique [0002] Cardiovascular disease is one of the most threatening diseases to humans today, and its morbidity and mortality have surpassed tumor diseases and ranked first. Actively treating hyperlipidemia is an important means to prevent cardiovascular and cerebrovascular diseases and reduce mortality. Lipid-lowering drugs have become the focus of modern drug research. With the increasing number of patients with hyperlipidemia around the world, the market potential of lipid-lowering drugs is becoming more and more obvious, and its market competition is becoming more and more fierce. In the 1940s, phenoxyaromatic acid (fibrates) drugs were first listed on the market. Phenoxyaromatic acid drugs are broad-spectrum systemic lipid regulators, which are ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/52A61K31/192A61K47/38A61P3/06
Inventor 梅开忠黄欣
Owner 天津梅花生物医药科技有限公司
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