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A kind of preparation method of oral liquid

A technology for oral liquids and vitamins, which is applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, etc. It can solve problems such as easy precipitation and impact on drug quality

Active Publication Date: 2020-01-03
谈发金
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the oral liquid prepared according to this process is easy to precipitate and precipitate during the placement process, which affects the quality of the drug

Method used

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  • A kind of preparation method of oral liquid
  • A kind of preparation method of oral liquid
  • A kind of preparation method of oral liquid

Examples

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preparation example Construction

[0032] The invention discloses a preparation method of an oral liquid, and those skilled in the art can refer to the content of this article and appropriately improve the process parameters to realize it. In particular, it should be pointed out that all similar replacements and modifications are obvious to those skilled in the art, and they are all considered to be included in the present invention. The method and application of the present invention have been described through preferred embodiments, and the relevant personnel can obviously make changes or appropriate changes and combinations to the method and application described herein without departing from the content, spirit and scope of the present invention to realize and Apply the technology of the present invention.

[0033] The raw materials or auxiliary materials used in the preparation method of the oral liquid provided by the invention can be purchased from the market.

Embodiment 1

[0035] The preparation of embodiment 1 oral liquid

[0036] Add 400g of sucrose to the sugar tank and add 700mL of purified water to make simple syrup, boil (95-105°C) for 30 minutes, keep the pressure at 0.05-0.08Mpa to obtain simple syrup, and then pump it through a plate and frame filter (200 mesh) into the batching tank.

[0037] Take 0.2g vitamin B 2 Add 100mL of purified water to dissolve, add 4% NaOH solution (containing 4g NaOH), so that the insoluble matter can be dissolved in large quantities, and the first premix is ​​obtained, which is filtered and transported to the batching tank.

[0038] Another 50g L-lysine hydrochloride, 0.25g nicotinic acid, 0.2g zinc sulfate, 5g iron glycerophosphate, 5g citric acid, 0.05g vitamin B 1 , 0.05g vitamin B 6 , 0.5g of sodium benzoate, and 0.01g of folic acid were added to 100mL of purified water, and dissolved to obtain the second premix, which was added to the batching tank.

[0039] Take 0.1g of vitamin E and dissolve it w...

Embodiment 2

[0041] The preparation of embodiment 2 oral liquid

[0042] First add 1000g sucrose to the sugar tank and add 700mL purified water to make simple syrup, boil (95-105°C) for 30 minutes, keep the pressure at 0.05-0.08Mpa to obtain simple syrup, and then pump it through a plate and frame filter (200 mesh) into the batching tank.

[0043] Take 0.4g vitamin B 2 Add 100mL of purified water to dissolve, add 4% KOH solution (containing 3.5g KOH), so that the insoluble matter can be dissolved in large quantities, and the first premix is ​​obtained, which is filtered and transported to the batching tank.

[0044] Another 30g L-lysine hydrochloride, 0.1g niacin, 0.4g zinc sulfate, 3g iron glycerophosphate, 6g citric acid, 0.1g vitamin B 1 , 0.03g vitamin B 6 , 3g of sodium benzoate, and 0.02g of folic acid were added to 100mL of purified water, and dissolved to obtain the second premix, which was added to the batching tank.

[0045] Take 0.06g of vitamin E and dissolve it with 30mL o...

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Abstract

The invention relates to the field of medicinal preparation, and particularly relates to a preparation method of an oral liquid. The preparation method comprises the following steps: obtaining simple syrup; mixing vitamin B2 with second water, and dissolving by adding alkali, thus obtaining first premix; mixing L-lysine hydrochloride, niacin, zinc sulfate, ferric glycerophosphate, citric acid, vitamin B1, vitamin B6, a preservative and folic acid with third water so as to obtain second premix; mixing vitamin E with ethyl alcohol so as to obtain a vitamin E solution; and mixing the simple syrup, the first premix and the second premix with the vitamin E solution, carrying out secondary heating, cooling, adding edible essence and the balance of water, uniformly mixing, filtering, adjusting pH value to 3.1-3.9, thus obtaining the oral liquid. According to the preparation method, the solubility of the vitamin B2 in the liquid medicine is improved by adding alkali to dissolve the vitamin B2 so as to make the increasing of the content of the vitamin B2 in the oral liquid possible, the oral liquid is stable in property and can be stored for a long time, and no precipitates are dissolved out from the oral liquid.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a preparation method of oral liquid. Background technique [0002] Iron is a trace element needed in the physiological process of the human body. It exists in all living cells. In addition to participating in the synthesis of hemoglobin, it also participates in some other biochemical processes in the body, such as electron transfer in the mitochondria of cells, metabolism and synthesis of catecholamines. Various enzymes in the body need iron, such as cytochrome, peroxidase, cytochrome C reductase, ribonucleic acid reductase and xanthine oxidase and other oxidoreductases all contain iron. Iron-deficiency anemia is anemia that occurs due to the lack of iron stored in the body due to various reasons, which affects the synthesis of heme in cells. The World Health Organization reported in 1985 that 30% of the world suffers from anemia, 50% of which are iron-deficiency anemi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K33/42A61K9/08A61K47/18A61K47/04A61K47/12A61P3/02A61K31/519A61K31/525A61K31/51A61K31/455A61K31/4415A61K31/198A61K31/355A61K33/30
Inventor 谈发金郑桂林柳卓
Owner 谈发金
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