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Pharmaceutical composition for treating hydrosalpinx and preparation method thereof

A composition and drug technology, applied in the field of pharmaceutical composition for treating hydrosalpinx and its preparation, can solve the problems of poor ovarian response, hydrosalpinx, high cost, etc., achieve simple and effective hydrosalpinx, solve hydrosalpinx, hydrosalpinx, Ease of use

Inactive Publication Date: 2016-06-29
SHANGHAI INST OF PLANNED PARENTHOOD RES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Laparoscopic salpingectomy may destroy the vascular network in the mesosalpinx of the affected side, thereby affecting the blood supply of the corresponding ovary, resulting in poor response of the ovary during ovulation induction; salpingostomy may cause recurrence of hydrops, and only Limited to patients with mild hydrosalpinx; tubal ligation and proximal tubal embolization may form tubal cysts leading to torsion, and proximal tubal embolization may affect the internal environment of the uterine cavity and even induce uterine contractions due to foreign bodies in the uterus during pregnancy; and The above operations are relatively complicated, and the patients need general anesthesia and the cost is high
Ultrasound-guided transvaginal hydrosalpinx aspiration through the posterior fornix is ​​a simple, fast and effective method, but hydrosalpinx aspiration cannot solve the problem of rapid recurrence of hydrosalpinx in the fallopian tube cavity, and the hydrosalpinx will recover within a few hours undisturbed

Method used

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  • Pharmaceutical composition for treating hydrosalpinx and preparation method thereof
  • Pharmaceutical composition for treating hydrosalpinx and preparation method thereof
  • Pharmaceutical composition for treating hydrosalpinx and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-6

[0077] Embodiment 1-6, preparation pharmaceutical composition

[0078] According to the formula described in Table 1, weigh and mix the components of the medicinal materials, add cold water to soak for 20-30 minutes, the amount of water added is the total weight of the medicinal materials (g) × 10ml, and make it 2-3cm higher than the medicinal surface. First boil on high heat and then fry with slow fire for 40-50 minutes; put the liquid medicine in a small bowl, add cold water to the medicine dregs and fry for the second time for 30 minutes, the amount of water added is the total weight of medicinal materials (g) × 6ml, and fry twice After the liquid medicine is mixed, about 300ml of the pharmaceutical composition (decoction) of the present invention is obtained. Also can add excipient or diluent to make pharmaceutical composition preparation in the composition that embodiment 1, embodiment 2, embodiment 3, embodiment 4, embodiment 5 and embodiment 6 obtain, make excipient or ...

Embodiment 7

[0081] Embodiment 7, pharmacodynamic experiment of pharmaceutical composition

[0082] 1. Materials and Methods

[0083] 1.1 Research objects and groups

[0084] A total of 587 patients who received IVF-ET treatment due to tubal factor infertility in Shanghai Institute of Family Planning and Reproductive Medicine Center of Shanghai Changhai Hospital from January 2010 to July 2013 were selected, with an average age of 31.2 years and infertility time of 1 ~10 years. Among them, according to past medical history, HSG examination and vaginal B-ultrasound examination were divided into hydrosalpinx group, salpingectomy group and chronic pelvic inflammation without hydrosalpinx group.

[0085] 1.2. Diagnostic criteria

[0086] Hydrosalpinx group: before IVF-ET, hysterosalpingography (HSG) indicated hydrosalpinx, and B-ultrasound examination found a hypoechoic banded area around the ovary and irregular vaginal discharge symptoms, suggesting that there was a fallopian tube Fluid re...

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PUM

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Abstract

The invention relates to a pharmaceutical composition for treating hydrosalpinx and a preparation method thereof. The pharmaceutical composition is basically composed of the following medicinal material components or extracts thereof: Rehmannia glutinosa; Radix Paeoniae Alba; Salvia miltiorrhiza; Angelica; Rehmannia glutinosa; Mian 萆 薢; Lycium barbarum; Ophiopogon japonicus; Zhuru; Atractylodes macrocephala; Turmeric; Achyranthes bidentata; The preparation method comprises the following steps: (1) weighing and mixing the above medicinal components to obtain a mixture; (2) adding a pharmaceutically acceptable carrier to the mixture, and mixing to obtain the product. The invention can not only have obvious therapeutic effect on hydrosalpinx, quickly solve the symptoms caused by hydrosalpinx and the adverse effect of hydrosalpinx on IVE-ET, but also have no negative impact on human endocrine and ovary, etc., simple and effective, And the price is low, and it is easy to use in a large range.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition, in particular to a medicinal composition for treating hydrosalpinx and a preparation method thereof. Background technique [0002] Hydrosalpinx is a common type of pelvic inflammatory disease (PID), and it is also one of the main indications for IVF-ET. However, patients with hydrosalpinx directly receive IVF-ET (in vitro fertilization and embryo transfer) with poor efficacy. It may be that the embryotoxic effect of water accumulation reduces the embryo implantation rate and pregnancy rate, and increases the miscarriage rate; or the uterine cavity reflux of water accumulation has a mechanical washing effect on the embryo, which affects the implantation of the embryo. Therefore, before IVF-ET Pretreatment of hydrosalpinx is necessary. [0003] So far, the pretreatment methods for hydrosalpinx before IVF-ET are mainly various surgical interventions, including salpingectomy, salpingosto...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9066A61P15/00
Inventor 张慧琴施惠娟黄先亮松迪朱旻杜惠王健张文静
Owner SHANGHAI INST OF PLANNED PARENTHOOD RES
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