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A kind of wettable andrographis paniculata powder and preparation method thereof

A kind of andrographis paniculata, wet technology, applied in the field of wettable andrographis paniculata powder and its preparation, can solve the problems of difficulty in mixing uniformly, not suitable for large-scale breeding, time-consuming and laborious, etc.

Inactive Publication Date: 2016-03-30
CHENGDU QIANKUN VETERINARY PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Andrographis paniculata unilateral dosage forms available in veterinary clinic include Churographis paniculata tablets, Andrographis paniculata powder, and Andrographis paniculata injection. Feed administration, feed administration requires that the drug and feed be mixed evenly, but it is difficult to mix evenly in actual operation, which may easily cause excessive drug intake, poisoning or too little drug intake without curative effect; and feed administration is easy to change the feed Flavor, causing animal refueling stress, resulting in a decrease in animal feed intake and no therapeutic effect; injection formulations have good therapeutic effects, but are time-consuming and laborious, and are not suitable for large-scale farming

Method used

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  • A kind of wettable andrographis paniculata powder and preparation method thereof
  • A kind of wettable andrographis paniculata powder and preparation method thereof
  • A kind of wettable andrographis paniculata powder and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0209] The formula screening of embodiment 1 wettable Andrographis paniculata powder

[0210] The screening formula is shown in formula 1 to formula 6 in Table 1:

[0211] The preferred scheme of table 1 wettable Andrographis paniculata powder formula

[0212]

[0213] Weigh the raw materials of each weight portion in formula 1 to formula 6 in Table 1 respectively, and grind Andrographis paniculata into 625-mesh fine powder for subsequent use;

[0214] Mix povidone K-30, tannic acid, 1.2~26L absolute ethanol, add butyl anisole, stir to dissolve, add the fine powder prepared before, mix well, ventilate and dry at 50°C, then add a Spartame, phosphatidic acid, and sodium carboxymethylcellulose are mixed evenly and pulverized to obtain wettable andrographis paniculata powder prepared from formula 1 to formula 6.

[0215] The wettable andrographis paniculata powder prepared from formulas 1 to 6 were evaluated for dispersion quality, sedimentation volume ratio quality evaluatio...

Embodiment 2

[0232] The preparation of embodiment 2 wettable Andrographis paniculata powder

[0233] formula:

[0234]

[0235] Get Andrographis paniculata and be crushed into 700 mesh fine powder for subsequent use;

[0236] Take povidone K-30, add 5L of absolute ethanol, mix, stir to dissolve, add the fine powder prepared above, mix evenly, ventilate and dry at 35°C, add carboxymethylcellulose sodium, mix evenly, and pulverize to obtain The wettable andrographis paniculata powder of the present invention.

Embodiment 3

[0237] The preparation of embodiment 3 wettable Andrographis paniculata powder

[0238] formula:

[0239]

[0240] Get Andrographis paniculata and be crushed into 1000 mesh fine powder for subsequent use;

[0241] Mix povidone K-30, tannic acid, and absolute ethanol 19.4L, stir to dissolve, add the fine powder prepared before, mix evenly, ventilate and dry at 40°C, add aspartame, phosphatidic acid, carboxymethyl The sodium cellulose is mixed and pulverized to obtain wettable Andrographis paniculata powder of the present invention.

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Abstract

The invention relates to the technical field of veterinary medicine preparation and particularly relates to wettability andrographis paniculata powder and a preparation method thereof. The wettability andrographis paniculata powder which can easily and uniformly disperse in water and is beneficial to administration with water is prepared by adding a suspending agent and a dispersing agent on the basis of an andrographis paniculata effective component through the reasonable medicine proportioning. The wettability andrographis paniculata powder provided by the invention is convenient to use and has a good treatment effect. The survey tests on the curative effect on animals show that the treatment effect of the wettability andrographis paniculata powder on swine pneumonia is obviously superior to that of tilmicosin premix (P is less than 0.05), and the treatment effect of the wettability andrographis paniculata powder on broiler chicken pullorum disease is obviously superior to that of commercially available andrographis paniculata powder (P is less than 0.05). The invention also provides a preparation method of the wettability andrographis paniculata powder. The preparation method is simple in process, low in production cost and suitable for industrial mass production.

Description

technical field [0001] The invention relates to the technical field of veterinary drug preparation, in particular to a wettable andrographis paniculata powder and a preparation method thereof. Background technique [0002] Andrographis paniculata, also known as spring lotus and autumn willow, Yi Jianxi, Lavender lotus, bitter gall grass, golden vanilla, golden ear hook, Indian grass, bitter grass, etc., is a plant of the genus Andrographis of the family Acanthaceae. , large intestine, and bladder meridians are commonly used Chinese herbal medicines with a wide range of sources and few side effects. Andrographis paniculata has the functions of clearing heat and detoxifying, cooling blood and detumescence. When used with mint, chrysanthemum, and bellflower, it can clear throat and sharp throat; when used with gypsum, Anemarrhena, honeysuckle, and forsythia, it can clear lungs, relieve fire and detoxify; Folium Folium is used to cool blood, detoxify and reduce swelling. Andro...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/19A61P11/00A61P1/12A61P31/04
Inventor 丁晓刚房春林李犹平徐莎
Owner CHENGDU QIANKUN VETERINARY PHARMA
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