Eye drops containing hyaluronic acid or its salts and propylene glycol

Abstract

The present invention relates to an eye drop, which is an aqueous eye drop containing hyaluronic acid or its salt at a concentration of 0.03 to 0.5% (w / v) and propylene glycol at a concentration of 0.1 to 1.0% (w / v), Wherein, the eye drops contain benzalkonium chloride at a concentration of 0.001 to 0.002% (w / v) as the only preservative, and contain ionic acid, etc. penetrating agent.

Description

technical field [0001] The present invention relates to an aqueous eye drop containing hyaluronic acid or its salt at a concentration of 0.03 to 0.5% (w / v) and propylene glycol at a concentration of 0.1 to 1.0% (w / v). The eye drop contains 0.001 Benzalkonium chloride is used as the only preservative at a concentration of ~0.002% (w / v), and an ionic isotonizing agent is contained at a concentration that makes the osmotic pressure ratio of the eye drops 0.9-1.1. In addition, the present invention also relates to a method for improving the preservation efficacy of eye drops containing sodium hyaluronate at a concentration of 0.1 or 0.3% (w / v) and containing benzalkonium chloride as the sole preservative, and This method makes the kinematic viscosity of the eye drops reach 3.0-4.0 or 17-30mm 2 / s, and prevent dripping of the eye drops, the method includes: sodium hyaluronate in an amount of 0.1 or 0.3% (w / v) in the eye drops, the eye drops Benzalkonium chloride in an amount of 0...

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Problems solved by technology

However, in fact, if the preservative concentration in the eye drops is reduced, sufficient preservation effect cannot be obtained when using in a multi-dose form, and the compounding ingredients are changed along with the reduction of the preservative, so it is also There is concern that the physicochemical properties of the eye drops will be different from those of the existing sodium hyaluronate eye drops

[0008] In addition, although Japanese Patent Application Publication No. 2004-359629 (Patent Document 1), Japanese Patent Application Publication No. 2009-196903 (Patent Document 2), and Japanese Patent Application Publication No. 2009-161454 (Patent Document 3) disclose An eye drop containing sodium hyaluronate, benzalkonium chloride, and propylene glycol has sufficient preservation efficacy even though the concentration of benzalkonium chloride in the eye drop is 0.0025% or less, and has the same effect as the existing There is no record of the same physical and chemical properties of sodium hyaluronate eye drops

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