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Application of Liuwei Anxiao pharmaceutical composition and its preparation in the preparation of drugs for treating alcoholic hepatitis

A technology for alcoholic hepatitis and Liuwei Anxiao, which is applied in the field of medicine, can solve the problems such as no research report on the drug composition of Liuwei Anxiao, and achieve the effect of remarkable curative effect and wide clinical application.

Active Publication Date: 2015-10-28
JINKE TIBETAN MEDICINE QINGHAI PROV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] There are no relevant research reports on the application of Liuwei Anxiao pharmaceutical composition and its preparation in the preparation of drugs for the treatment of alcoholic hepatitis in the above patents and literature

Method used

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  • Application of Liuwei Anxiao pharmaceutical composition and its preparation in the preparation of drugs for treating alcoholic hepatitis

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1、 6

[0023] Experimental example 1, the preparation of Liuwei Anxiao medicinal composition and preparation thereof

[0024] 1. Prescription: Zangmuxiang 75g, Rhubarb 300g, Shannai 150g, Calcined Beihanshui Stone 375g, Myrobalan 225g, Suihua 450g;

[0025] 2. Preparation of active ingredients

[0026] (1) According to the composition of the raw materials, four medicinal materials, including Tibetan woody fragrance, rhubarb, kaemania, and myrobalan, were extracted twice with 70% ethanol under reflux, and the extraction time was 2 hours each time, and the amount of each solvent was 10% of the weight of the medicinal materials. times the volume, filtered to obtain medicinal residue A and extract A, extract A to recover ethanol under reduced pressure, concentrate, and dry to obtain extract A;

[0027] (2) Decoct the alkali flower composed of medicinal dregs A and the raw material medicine obtained in step (1), and the calcined Beihan water stone composed of half of the raw material, de...

experiment example 2

[0033] Experimental example 2, clinical observation of treatment of alcoholic hepatitis

[0034] In order to better understand the essence of the present invention, the following pharmacological tests and clinical observation tests are used to prove the effect of Liuwei Anxiao pharmaceutical composition and its preparation on "treating alcoholic hepatitis", and to illustrate its new application in the field of pharmacy.

[0035] Case inclusion criteria

[0036] According to the diagnostic criteria for alcoholic liver disease formulated by the Fatty Liver and Alcoholic Liver Disease Group of the Liver Disease Branch of the Chinese Medical Association in October 2010:

[0037] 1) Long-term drinking history, generally more than 5 years, equivalent to alcohol volume, male ≥ 40g / d, female ≥ 20g / d, or history of heavy drinking within 2 weeks (> 80g / d);

[0038] 2) The increase of aspartate aminotransferase (AST) is significantly greater than the increase of alanine aminotransferase...

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Abstract

The invention discloses the application of Liuwei Anxiao pharmaceutical composition and its preparation in the preparation of drugs for treating alcoholic hepatitis. It is composed of six herbs such as seed and alkali flower. Clinical trials have shown that the Liuweian Xiaosan pharmaceutical composition has a protective effect on alcoholic liver injury, and can significantly improve biochemical indicators such as AST, ALT, GGT, and TBiL. <pb pnum="1" / >

Description

technical field [0001] The invention relates to the application of Liuwei Anxiao pharmaceutical composition and its preparation in the preparation of medicines for treating alcoholic hepatitis, belonging to the field of medicine. Background technique [0002] Alcoholic hepatitis is a clinical type of alcoholic liver disease. It is a group of clinicopathological syndromes caused by massive necrosis of liver cells in a short period of time. It can occur on the basis of liver cirrhosis with or without liver cirrhosis. The main manifestations are elevated serum ALT and AST and serum total bilirubin were significantly increased, which may be accompanied by fever and elevated neutrophils in peripheral blood. [0003] The main clinical manifestation of alcoholic hepatitis is the rapid onset of jaundice. Other symptoms and signs include fever, ascites, and proximal muscle relaxation. Patients with severe alcoholic hepatitis may develop hepatic encephalopathy. Typically, patients wi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/906A61P1/16A61K33/00A61K33/06
Inventor 彭坤邵成雷单玉刚付素心王海苹
Owner JINKE TIBETAN MEDICINE QINGHAI PROV
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