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A traditional Chinese medicine composition for treating non-alcoholic fatty liver disease and its preparation method

A fatty liver disease, non-alcoholic technology, applied in the direction of drug combinations, pharmaceutical formulas, medical preparations containing active ingredients, etc., can solve problems such as unsatisfactory curative effects

Inactive Publication Date: 2016-01-20
SHANDONG PROVINCIAL HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Mainly on the basis of removing the etiology and incentives and treating the primary disease, according to the specific condition of the patient, drugs such as improving insulin resistance, regulating blood lipids, antioxidants, and protecting the liver have not been achieved.

Method used

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  • A traditional Chinese medicine composition for treating non-alcoholic fatty liver disease and its preparation method
  • A traditional Chinese medicine composition for treating non-alcoholic fatty liver disease and its preparation method
  • A traditional Chinese medicine composition for treating non-alcoholic fatty liver disease and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] Recipe: Yanhuanglian 300g, Huhuanglian 200g, Panax notoginseng 300g, Danshen 200g, Pueraria 150g, Atractylodes macrocephala 150g, Paeoniae Alba 300g, Poria cocos 200g, Bupleurum 150g, Angelica 150g, lotus leaf 300g, coix seed 300g, winter melon kernel 300g, reed Root 200g, Campanulaceae 150g, Tinglizi 150g, Loquat leaves 150g, Chuan Fritillaria 150g, Lycium barbarum 120g, Cassia seeds 120g, Alisma 120g, peach kernel 100g, mulberry leaves 50g.

[0065] Preparation method: Take the above raw materials and add 60% ethanol to reflux extraction three times, each time for 1.5 hours, combine the extracts, filter, recover the ethanol from the filtrate until it has no alcohol smell, concentrate to a relative density of 1.15-1.25 (70°C), add microcrystalline Cellulose, starch, mixed, boiling granulation, adding micropowder silica gel, mixed, pressed into 1000 tablets.

Embodiment 2

[0067] Recipe: Yanhuanglian 350g, Huhuanglian 250g, Panax notoginseng 350g, Danshen 250g, Pueraria 180g, Atractylodes macrocephala 180g, Paeoniae Alba 350g, Poria cocos 250g, Bupleurum 180g, Angelica 180g, lotus leaf 350g, coix seed 350g, winter melon kernel 350g, reed Root 250g, Campanulaceae 180g, Tinglizi 180g, Loquat leaves 180g, Chuan Fritillaria 160g, Lycium barbarum 150g, Cassia seeds 150g, Alisma 150g, peach kernel 100g, mulberry leaves 50g.

[0068] Preparation method: Take the above-mentioned raw materials and add 70% ethanol to reflux and extract three times, each time for 1.5 hours, combine the extracts, filter, recover the ethanol from the filtrate until it has no alcohol smell, concentrate to a relative density of 1.15-1.25 (70°C), add microcrystals Cellulose and starch, mixed evenly, boiled and granulated, dried, packed into capsules, and made into 1200 capsules.

Embodiment 3

[0070] Recipe: Yanhuanglian 250g, Huhuanglian 150g, Panax notoginseng 250g, Danshen 180g, Pueraria 120g, Atractylodes macrocephala 100g, Paeoniae Alba 250g, Poria cocos 150g, Bupleurum 100g, Angelica 100g, lotus leaf 300g, coix seed 250g, winter melon kernel 250g, reed Root 200g, Campanulaceae 150g, Tinglizi 120g, Loquat leaves 120g, Chuan Fritillaria 120g, Lycium barbarum 120g, Cassia seeds 120g, Alisma 120g, peach kernel 100g, mulberry leaves 50g.

[0071] Preparation method: same as Example 1, pressed into 800 tablets.

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Abstract

The invention discloses a traditional Chinese medicine composition for treating non-alcoholic fatty liver disease. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: corydalis saxicola, rhizoma picrorhizae, pseudo-ginseng, radix salviae miltiorrhizae, kudzuvine root, rhizoma atractylodis macrocephalae, radix paeoniae alba, tuckahoe, radix bupleuri, angelica, lotus leaves, semen coicis, chinese waxgourd semen, reed rhizome, platycodon grandiflorus, semen lepidii, loquat leaves, fritillaria cirrhosa, fructus lycii, semen cassia, rhizoma alismatis, peach kernel and mulberry leaves. Pharmacological experiments prove that the traditional Chinese medicine composition is capable of preventing insulin resistance, improving insulin sensitivity, reducing blood fat, inhibiting inflammatory reaction, improving abnormal glucolipid metabolism, reducing hepatocyte fat deposition, improving liver function, decreasing liver indexes and having obvious treatment effects on a rat suffering from non-alcoholic fatty liver disease.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition for treating nonalcoholic fatty liver disease and a preparation method thereof, belonging to the field of traditional Chinese medicines. Background technique [0002] Non-alcoholic fatty liver disease (NAFLD) refers to a clinicopathological syndrome characterized by diffuse hepatic bullous steatosis caused by excluding alcohol and other definite liver damage factors, including simple fatty liver and caused by Its evolution is steatohepatitis (NASH) and cirrhosis. Its risk factors include obesity, type 2 diabetes mellitus (T2DM), hyperlipidemia and so on. According to reports, the prevalence of NAFLD in ordinary adults is 17% to 33%, of which 1 / 3 to 1 / 2 is NASH, and the incidence of liver cirrhosis within 10 years is 15% to 25%. The incidences of simple fatty liver, NASH and liver cirrhosis in obese people are higher, 60%-90%, 20%-25% and 2%-8%, respectively. The detection rates of N...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8994A61P1/16
Inventor 李婕孙建光张娇任万华
Owner SHANDONG PROVINCIAL HOSPITAL
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