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Preparation technology of lauromacrogol

A preparation process, the technology of lauromacrogol, which is applied in the field of lauromacrogol preparation process, can solve the problems of product instability and low yield, and achieve the effects of high product yield, reduction of industrial production cost, and simplified operation

Inactive Publication Date: 2014-02-12
ANHUI YOUCARE KAIYUE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing technology when producing and preparing lauromacrogol, yield is not high, and product is unstable

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] A preparation process of lauromacrogol, comprising the following steps:

[0016] (1) Add 204g of dodecanol and 0.9g of potassium hydroxide into a clean, dry, and well-sealed autoclave, seal it, stir evenly and heat up to 100°C, vacuumize, the vacuum degree is below -0.9MPa, and remove water 1h, fill with nitrogen until the pressure inside the kettle reaches 0.3MPa, and then vacuumize to below -0.9MPa;

[0017] (2) Heat up the autoclave in the above steps to 165°C, stir rapidly, and feed 25g of ethylene oxide to initiate the reaction. When the pressure in the kettle drops to 0.1MPa, continue to feed in the remaining 415g of ethylene oxide, and control the flow rate to make the pressure in the kettle No more than 0.35MPa, keep the temperature at 165°C;

[0018] (3) After continuing to feed a sufficient amount of ethylene oxide into the above steps, keep the temperature and continue stirring for 1 hour, cool down to 80° C., vacuumize for 20 minutes, remove the remaining e...

Embodiment 2

[0022] A preparation process of lauromacrogol, comprising the following steps:

[0023] (1) Add 300g of dodecanol and 1.323g of potassium hydroxide into a clean, dry, well-sealed autoclave, seal it, stir evenly and heat up to 120°C, vacuumize, the vacuum degree is below -0.9MPa, and remove water 1.5h, filled with nitrogen, until the pressure in the kettle reached 0.35MPa, and vacuumed to below -0.9MPa;

[0024] (2) Heat the autoclave in the above steps to 170°C, stir rapidly, and feed 73.5g of ethylene oxide to initiate the reaction. When the pressure in the kettle drops to 0.1MPa, continue to feed the remaining 573.3g of ethylene oxide, and control the flow rate to make the kettle The internal pressure does not exceed 0.35MPa, and the temperature is maintained at 175°C;

[0025] (3) After continuing to feed a sufficient amount of ethylene oxide into the above steps, keep the temperature and continue to stir for 1.5 hours, cool down to 90° C., vacuumize for 20 minutes, remove...

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PUM

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Abstract

The invention relates to a preparation technology of lauromacrogol. The preparation technology takes lauryl alcohol, potassium hydroxide, oxirane, absolute ethyl alcohol and activated carbon as raw materials. The preparation technology is simple; no special equipment is required; a solvent can be recycled, so that the industrial production cost is lowered; potassium hydroxide serves as a catalyst, so that operation is simplified; the content of heavy metal is controlled easily according to a medicinal quality standard requirement; lauromacrogol is high in yield.

Description

technical field [0001] The invention relates to a preparation process of lauromacrogol. Background technique [0002] Lauromacrogol injection has become one of the main methods for treating varicose veins due to its high efficiency, safety and quickness. Varicose veins is a common and frequently-occurring disease of the venous system with a history of more than 150 years. When the existing technology is producing and preparing lauromacrogol, the yield is not high and the product is unstable. Contents of the invention [0003] The object of the present invention is to provide a kind of lauromacrogol preparation technology. [0004] The purpose of the present invention can be achieved through the following technical solutions: [0005] A preparation process of lauromacrogol, comprising the following steps: [0006] Add dodecanol and potassium hydroxide into a clean, dry, and well-sealed autoclave, seal it, stir evenly, heat up to 100°C-120°C, vacuumize, the vacuum degree ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G65/28
CPCC07C29/82C07C31/125C07C41/03C07C43/11
Inventor 周如国
Owner ANHUI YOUCARE KAIYUE PHARMA
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