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Applications of leonurine in preparation of medicines used for treating atherosclerosis

A technology for atherosclerosis and motherurine, which is applied in the direction of drug combinations, pharmaceutical formulas, and medical preparations containing active ingredients, and can solve problems such as the atherosclerotic effect of motherurine that has not yet been seen

Inactive Publication Date: 2014-02-12
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there has been no report on the effect of motherurine on the treatment of atherosclerosis

Method used

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  • Applications of leonurine in preparation of medicines used for treating atherosclerosis
  • Applications of leonurine in preparation of medicines used for treating atherosclerosis
  • Applications of leonurine in preparation of medicines used for treating atherosclerosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Example 1 Leonurine affects lipid levels in blood

[0030]The experimental rabbits were fed with common feed for one week under the experimental conditions to adapt to the environment, and the formal experiment began one week later. Observe the animal's expression, coat color, food intake, and defecation every day, and weigh the body weight every week to monitor the growth status. Hematological testing includes determination of blood lipid content: Fasting the experimental animals for 12 hours at the end of week 0, week 4, and week 8 respectively, taking blood from the ear vein, the blood volume is 2ml, standing for 2hr, centrifuging at 3000r / min at 4°C for 10min, and taking clear. The contents of TC, TG, LDL-C and HDL-C were determined by enzymatic method, and determined by automatic biochemical analyzer. Measurement of hemorheology indexes: Before the animal was sacrificed, 4ml of blood was taken from the middle ear artery, anticoagulated with heparin sodium and sod...

Embodiment 2

[0032] Embodiment 2. Leonurine relieves plaque formation in common carotid artery

[0033] At the beginning of the experiment and at the end of the 8th period, the experimental rabbits were lightly anesthetized with 3% pentobarbital sodium 30mg / kg ear vein injection, the chest skin was prepared, and the M-shaped sampling line was perpendicular to the interventricular septum and left ventricle at the papillary muscle level The image of the plaque proximal to the bifurcation of the right common carotid artery was collected using a high-frequency microultrasound imaging system. M-mode echocardiography, measuring left ventricular diastolic diameter (LVDd), left ventricular systolic diameter (LVDs), cardiac cycle time (R-R), left ventricular shortening rate (FS), ejection fraction (EF), and output per minute Volume (CO), end-diastolic volume (EDV), stroke volume (SV), and heart rate (MMHR) were measured for 3 consecutive cardiac cycles, and the average value of the 3 times was tak...

Embodiment 3

[0035] Example 3 Leonurine improves the proliferation of common carotid arteries

[0036] At the end of the eighth week of the experiment, high-frequency microultrasound imaging system Vevo770 was used to detect carotid AS plaques. Rabbits were anesthetized with 3% pentobarbital sodium at a dose of 30 mg / kg, and the neck skin was prepared. Two-dimensional ultrasound was used to observe the plaque at the bifurcation of the common carotid artery and measure its blood flow velocity in the long-axis section of the carotid artery. The selected probe is RMV707B (resolution 30MHz), and the direction of the probe is adjusted so that the angle between it and the carotid artery is less than 60° to obtain the maximum blood flow signal. The maximum blood velocity (Vp), mean blood velocity (Vm) and velocity time integral (VTI) at 0.5cm of common carotid artery bifurcation were measured by pulsed Doppler to evaluate the hemodynamic state of rabbits. The intima-media thickness (IMT), end-di...

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Abstract

The invention belongs to the field of pharmacy, and relates to applications of leonurine in preparation of medicines used for treating atherosclerosis. Leonurine possesses a structure represented by formula (I). It is shown by results of experiments on a rabbit model with high fat diet induced atherosclerosis that, leonurine possesses anti-inflammatory activity and antioxidant activity, so that leonurine is capable of increasing the content of high-density lipoprotein, reducing the content of total cholesterol, reducing mean blood flow velocity of arteries, improving blood flowing states, protecting the integrity of blood vessel endothelium, and reducing deposition of lipid in blood vessels and generation of macrophage, and can be used for treating atherosclerosis.

Description

technical field [0001] The invention belongs to the field of pharmacy, and relates to the use of motherurine in the preparation of target organ protection drugs, especially the use in the preparation of drugs for treating atherosclerosis. Background technique [0002] Atherosclerosis (AS) is the most common and most important of a group of arteriosclerotic vascular diseases, which is characterized by the involvement of arterial lesions starting from the intima; generally there is accumulation of lipids and complex carbohydrates, hemorrhage and Thrombosis, fibrous tissue hyperplasia and calcinosis, and gradual degeneration and calcification of the arterial media, the lesions often involve elastic and large and medium muscular arteries, once it develops enough to block the arterial lumen, the tissues or organs supplied by the arteries will be damaged ischemia or necrosis. Atherosclerosis is called atherosclerosis because of the yellow ather-like appearance of lipids that buil...

Claims

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Application Information

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IPC IPC(8): A61K31/235A61P9/10
Inventor 朱依谆郭薇张延菲温雅丹熊青卉刘春华刘新华
Owner FUDAN UNIV
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