A kind of antibacterial hydrogel dressing and preparation method thereof

Abstract

The invention discloses an antibacterial and healing-promoting hydrogel dressing and a preparation method thereof. The main components of the dressing are water-soluble polymers, pseudoplastic functional polymers, antibacterial agents and water, which are melted together through a series of processes, and the solution is poured into a mold, cured and sterilized by radiation. . The results of wound healing test and in vitro antibacterial test show that the present invention can effectively promote wound healing, and has good antibacterial activity against various bacteria (the bactericidal rate is over 70%). The antibacterial and healing-promoting hydrogel dressing of the present invention is obviously superior to the existing hydrogel dressing, and has significant antibacterial curative effect, transparency, high water content, simple preparation method, pure product, non-toxic, harmless, non-irritating, and biocompatible Good performance and other advantages, suitable for large-scale promotion and application.

Description

technical field [0001] The invention belongs to the field of medical wound dressings and preparation thereof, in particular to an antibacterial and healing-promoting hydrogel dressing suitable for the protection and treatment of burns, mechanical wounds, surgical incisions and chronic wounds and a preparation method thereof. Background technique [0002] The skin is the largest organ of the human body, and it is a natural barrier to maintain the stability of the internal environment and prevent the invasion of microorganisms; however, the large area exposed to the outside world makes the skin vulnerable to external injuries such as burns and mechanical injuries. Because Staphylococcus aureus, Escherichia coli and other pathogens multiply on the wound, it is easy to cause wound infection; the infected wound is not easy to heal, and it is easy to cause loss of body fluid and various complications. [0003] Gauze-type dressings, known as traditional dressings, are generally mad...

AI Technical Summary

Problems solved by technology

The advantages of this type of dressing are: certain absorbency, easy to make, cheap, and reusable; the disadvantages are: the inability to keep the wound moist leads to delayed wound healing, the dressing fibers are likely to cause foreign body reactions and affect healing, and the newborn is easily damaged when changing dressings. Tissues and pathogens are easy to pass through the soaked dressing, and the workload of changing the dressing is heavy, and the bacterial resistance caused by the local application of antibiotics in the gauze dressing makes it difficult to heal the infected wound

[0006] "Polyvinyl Alcohol Hydrogel Dressing Containing Drugs and Chitosan and Its Preparation Method" (CN1320931C) published on June 13, 2007 discloses a polyvinyl alcohol hydrogel dressing containing drugs and chitosan , the medical hydrogel dressing can be used to treat various skin wounds and burns, but has the disadvantages of poor absorption of seepage fluid and the presence of harmful substances such as plasticizers; Nano-silver and carboxymethyl chitosan medical dressing and its preparation method" (CN102114265A) discloses a medical dressing containing nano-silver and carboxymethyl chitosan, which has good antibacterial effect, but has the ability to keep the wound moist, Lead to delayed wound healing; not easy to lift from the wound and other disadvantages; published on October 25, 2006 "Liquid wound dressing with promoting wound healing and antibacterial function" (CN100471528C) discloses a wound dressing with promoting wound healing and antibacterial function Liquid (gel-like) wound dressing, the medical dressing has the effect of anti-inflammatory, pain-relieving, and promoting wound healing, but has the disadvantage of poor ability to absorb exudate

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