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Traditional Chinese medicine composition for treating cardiovascular diseases and preparation method thereof

A composition and cardiovascular technology, applied in the direction of cardiovascular system diseases, drug combination, pharmaceutical formula, etc., to achieve the effect of small dose, good curative effect and high purity

Inactive Publication Date: 2014-01-15
TIANJIN TIANSHI BIOLOGICAL DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no drug prepared from seabuckthorn total flavonoid monomer components or monomer composition

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0085] (1) Take seabuckthorn medicinal material, crush it, add ethyl acetate and 70% ethanol at a volume ratio of 1:2, heat and reflux for extraction twice, the first time is 1.5 hours, the second time is 1 hour, and the filtrates are combined to obtain extract I , add 70% ethanol to the dregs, heat and reflux to extract twice, the first time is 1 hour, the second time is 0.5 hours, the filtrate is combined to obtain the extract II; the combined extracts I and II are concentrated into an extract, and dissolved in 50% methanol The extract is separated by macroporous resin AB-8, firstly eluted with water to obtain eluent I; then eluted with 55% ethanol, and then eluted with 90% ethanol, the flow rate of the eluent is 2.5BV / h , to obtain eluate II, recovery, concentration under reduced pressure, drying, total flavonoids of seabuckthorn. After testing, the product is 25.87%.

[0086] (2) Separation of isorhamnetin and quercetin;

[0087] (3) Take 8 g of isolated isorhamnetin and...

Embodiment 2

[0089] (1) Take seabuckthorn medicinal material, crush it, add ethyl acetate and 70% ethanol at a volume ratio of 1:2, heat and reflux for extraction twice, the first time is 1.5 hours, the second time is 1 hour, and the filtrates are combined to obtain extract I , add 70% ethanol to the dregs, heat and reflux to extract twice, the first time is 1 hour, the second time is 0.5 hours, the filtrate is combined to obtain the extract II; the combined extracts I and II are concentrated into an extract, and dissolved in 50% methanol The extractum is separated by macroporous resin X-5, and firstly eluted with water to obtain eluent I; then eluted with 60% ethanol, and then eluted with 95% ethanol, the eluent flow rate is 2BV / h, The eluate II was obtained, recovered, concentrated under reduced pressure, and dried to obtain the total flavonoids of seabuckthorn. After testing, the product was 26.53%.

[0090] (2) Separation of isorhamnetin and quercetin;

[0091] (3) Take 6 g of isolat...

Embodiment 3

[0093] (1) Take the seabuckthorn medicinal material, crush it, add ethyl acetate and 70% ethanol at a volume ratio of 1:2, heat and reflux for extraction twice, the first time is 2 hours, the second time is 1 hour, and the filtrates are combined to obtain the extract I , add 70% ethanol to the dregs, heat and reflux to extract twice, the first time is 1 hour, the second time is 0.5 hours, the filtrate is combined to obtain the extract II; the combined extracts I and II are concentrated into an extract, and dissolved in 50% ethanol Extract, adopt macroporous resin X-5 to separate, at first with water elution, obtain eluent I; Then with 55% ethanol elution, then with 95% ethanol elution, eluent flow rate is 2BV / h, The eluate II was obtained, recovered, concentrated under reduced pressure, and dried to obtain the total flavonoids of seabuckthorn. After testing, the product was 24.12%.

[0094] (2) Separation of isorhamnetin and quercetin;

[0095] (3) Take 3 g of isolated isorh...

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Abstract

The invention discloses a traditional Chinese medicine composition for treating cardiovascular diseases. The traditional Chinese medicine composition comprises 20-80 percent by weight of isorhamnetin and 20-80 percent by weight of quercetin. The invention also discloses a preparation method of the traditional Chinese medicine composition. The preparation method comprises the following steps: extracting total flavones of hippophae, separating the isorhamnetin and the quercetin, and preparing the finished product according to a formula. The traditional Chinese medicine composition disclosed by the invention has high purity and low dose. Compared with a conventional hippophae total flavone extractive preparation, the traditional Chinese medicine composition has a better curative effect and is more controllable in quality and suitable for industrial production.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition for treating cardiovascular diseases and a preparation method thereof, belonging to the field of traditional Chinese medicines. Background technique [0002] With the continuous improvement of people's living standards, changes in diet structure, population aging is becoming more and more obvious, and the incidence of coronary heart disease is increasing day by day. Coronary heart disease is a heart disease caused by narrowing of the lumen caused by coronary atherosclerosis, which causes myocardial blood supply and oxygen supply disturbance, and is known as the "world killer". As far as the whole world is concerned, coronary heart disease has become one of the most serious diseases threatening human health in the past half century, and it is the main cause of death in the United States and some industrialized countries. According to the statistics of the World Health Organization, 24....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61P9/10
Inventor 崔卜东贾林
Owner TIANJIN TIANSHI BIOLOGICAL DEV
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