Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Sample digestion method for measurement of iron content in medicine

A technology of iron content and samples, which is applied in the field of medicine, can solve the problems of strong acid corrosion, high risk, and long digestion time, and achieve the effects of avoiding high temperature operation, low risk, and easy operation

Inactive Publication Date: 2014-01-08
SHANDONG JINHE DRUG RES DEV
View PDF5 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Among the existing methods, the mixed acid digestion method has disadvantages such as complex operation, even requiring multiple digestions, strong acid corrosion, etc., and high risk; the ignition method has disadvantages such as cumbersome steps, high temperature operation, and long digestion time

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Sample digestion method for measurement of iron content in medicine
  • Sample digestion method for measurement of iron content in medicine
  • Sample digestion method for measurement of iron content in medicine

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0025] Experimental example 1: Selection of digestion conditions for determination of iron content in medicine

[0026] In this experiment, "iron powder" of Tibetan medicine decoction pieces was used as a sample, the iron content was determined by atomic absorption spectrophotometry, and the digestion method was selected. The specific steps are as follows:

[0027] 1. Instruments, reagents and test samples

[0028] Instruments: electronic balance: Shimadzu AUW220D type; A3 type atomic absorption spectrophotometer (Beijing General Analysis General Instrument Co., Ltd.).

[0029] Reference substance: ferric ammonium sulfate, iron element.

[0030] Sample: Herbal decoction pieces "iron powder" (provided by Qinghai Jinhe Tibetan Medicine Co., Ltd.), batch numbers: 120901, 120902, 120903.

[0031] 2. Experimental method and steps

[0032] 1) Iron standard stock solution: Accurately weigh 0.23g of ferric ammonium sulfate, add 10ml of 10% dilute nitric acid solution, dilute with p...

experiment example 2

[0049] Experimental example 2: Methodological verification experiment

[0050] 1. Instruments, reagents and test samples

[0051] Instruments: electronic balance: Shimadzu AUW220D type; A3 type atomic absorption spectrophotometer (Beijing General Analysis General Instrument Co., Ltd.).

[0052] Reference substance: ferric ammonium sulfate, iron element.

[0053] Sample: Herbal decoction pieces "iron powder" (provided by Qinghai Jinhe Tibetan Medicine Co., Ltd.), batch numbers: 120901, 120902, 120903.

[0054] 2. Experimental method and steps

[0055] 1) Iron standard stock solution: Accurately weigh 0.23g of ferric ammonium sulfate, add 10ml of 10% dilute nitric acid solution, dilute with pure water and quantify to a 500ml volumetric flask, shake well. Take 1ml of the solution and transfer it to a 100ml volumetric flask to constant volume, that is, ready.

[0056] 2) Standard curve: Precisely draw iron standard stock solution 0, 1, 2, 3, 5, 8, 10, 15ml into a 50ml volumetric...

Embodiment 1

[0071] Embodiment 1, a sample digestion method for the determination of iron content in medicine, the steps are as follows: take 1 g of medicinal material decoction pieces "iron powder" powder, weigh it accurately, put it in a round bottom flask, add 15%-35% nitric acid solution 50-100ml , 80 ℃ -100 ℃ with a plug seal and soak for 2-4 hours, continue to heat to boiling, reflux for 2-4 hours, cool, filter, that is.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a sample digestion method for measurement of the iron content in a medicine. Nitric acid with the concentration of 15-40% is used, and iron in the medicine can be totally digested through digesting and boiling reflux. After a digested sample solution is diluted, measurement of the iron content can be further carried out through an atomic absorption spectrometry. The method is high in safety, simple to operate, complete in iron digestion, and capable of taking the place of a method that strong-corrosion mixed acid is used for sample digestion in the prior art.

Description

technical field [0001] The invention relates to a sample digestion method for measuring iron content in medicine, which belongs to the technical field of medicine. Background technique [0002] Iron has the effect of promoting the production of red blood cells in the human body. Many medicines contain iron, and iron powder is even used directly as medicine. The iron powder used in medicine is generally used after processing, which is more conducive to absorption. However, excessive intake of iron may cause acute iron poisoning, and severe cases may cause shock or even death. Therefore, it is necessary to measure and control the iron content of drugs, especially those containing iron powder in the formula. [0003] Herbal decoction pieces "iron powder" are commonly used in Tibetan medicine, such as Liuwei Mingmu pills and Qiwei Tiefen powder. "Iron powder", the herbal medicine used in Tibetan medicine, is made by heating pig iron particles, decocting the extract of cypress ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): G01N1/44G01N21/31
Inventor 周兰英孙绪丁单玉刚王朔赵延霞
Owner SHANDONG JINHE DRUG RES DEV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com