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A kind of calcium zinc gluconate compound

A technology of zinc gluconate and crystal compounds, applied in organic chemistry, carboxylate preparation, organic active ingredients, etc., can solve the problems of decreased resistance, bacterial, viral and other microbial infections, and achieve good stability and easy product purity The effect of control and stable yield

Inactive Publication Date: 2015-08-26
洪军 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, zinc deficiency in the body can reduce the body's resistance and make it susceptible to microbial infections such as bacteria and viruses.

Method used

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  • A kind of calcium zinc gluconate compound
  • A kind of calcium zinc gluconate compound
  • A kind of calcium zinc gluconate compound

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Embodiment 1: the preparation of zinc gluconate crystal compound

[0038] Take 3.00g of zinc gluconate crude product, dissolve it into 120mL of purified water, control the temperature at 25°C, add 60mL of methyl ethyl ketone dropwise under stirring for 50 minutes, stop stirring after the dropwise addition, let stand at 20-25°C for 8h, and filter with Washed with 100 mL of methyl ethyl ketone, pumped dry, and dried in vacuum to obtain 2.78 g of zinc gluconate crystals, with a yield of 92.7%.

[0039] Its X-ray powder diffraction pattern and infrared spectrum are respectively as figure 1 and 2 shown.

Embodiment 2

[0040] Embodiment 2: the preparation of zinc gluconate crystal compound

[0041] Take 5.00g of crude zinc gluconate, dissolve it in 220mL of purified water, control the temperature at 20°C, add 100mL of methyl ethyl ketone dropwise under stirring for 60 minutes, stop stirring after the addition is complete, let stand at 25°C for 8h, filter with suction, and add 130mL of methyl ethyl ketone Washing, drying, and vacuum drying yielded 4.66 g of zinc gluconate crystals, with a yield of 93.2%.

[0042] Its X-ray powder diffraction pattern and infrared spectrum are consistent with embodiment 1.

Embodiment 3

[0043] Embodiment 3: the preparation of zinc gluconate crystal compound

[0044] Take 5.00g of crude zinc gluconate, dissolve it in 280mL of purified water, control the temperature at 25°C, add 250mL of methyl ethyl ketone dropwise under stirring for 60 minutes, stop stirring after the addition is complete, let stand at 25°C for 8h, filter with suction, and add 330mL of methyl ethyl ketone Washing, drying, and vacuum drying yielded 4.58 g of zinc gluconate crystals, with a yield of 91.6%.

[0045] Its X-ray powder diffraction pattern and infrared spectrum are consistent with embodiment 1.

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Abstract

The invention relates to a calcium zinc gluconate crystal compound and a preparation method thereof as well as a pharmaceutical composition comprising the same. The calcium zinc gluconate crystal compound has better stability and solubility, and the preparation process is easy to industrialize, thereby being the best choice for clinical medication.

Description

technical field [0001] The invention belongs to the field of medicinal chemistry, in particular to calcium zinc gluconate compounds. Background technique [0002] Zinc is one of the trace elements necessary for human normal immunity and growth and development. It is an essential component or activator of more than 80 enzymes such as carbonic anhydrase and lactate dehydrogenase in the body. It is a factor that regulates gene expression, that is, DNA replication, translation and transcription An essential component of DNA polymerase. In recent years, it has been found that zinc plays an important role in the DNA synthesis of immune cells. The thymus atrophy of zinc-deficient animals, the weight of thymus and spleen are reduced, and the impairment of T cell function causes changes in cell-mediated immunity and reduces immunity. Therefore, zinc deficiency in the body can reduce the body's resistance and make it susceptible to microbial infections such as bacteria and viruses. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C59/105C07C51/41A61K31/191A61K9/16
CPCC07C51/41C07C59/105
Inventor 洪军刘洪
Owner 洪军
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