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Maduramicin ammonium nicarbazin premix and preparation method thereof

A technology of maldomecin ammonium and nicarbazine, which is applied in the directions of pharmaceutical formulations, medical preparations containing active ingredients, organic active ingredients, etc., can solve the problems of mixing uniformity and other problems, and achieves good mixing uniformity and fluidity. Good, easy-to-mix results

Inactive Publication Date: 2014-01-01
ZHENGZHOU FUYUAN ANIMAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the invention is to solve the mixing homogeneity problem (especially maduramicin ammonium) in the production process of maduramicin ammonium nicarbazine premix

Method used

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  • Maduramicin ammonium nicarbazin premix and preparation method thereof
  • Maduramicin ammonium nicarbazin premix and preparation method thereof
  • Maduramicin ammonium nicarbazin premix and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0024] Dissolve 0.6kg of maduromycin ammonium in 5kg of ethyl acetate and set aside. Add 86.9kg of cornstarch (passed through a 60-mesh sieve) into the fluidized bed, first fluidize and dry it for 25 minutes, then add 12.5kg of nicarbazine into the fluidized bed, mix for 15 minutes, and finally spray into the maduramicin Ammonium ethyl acetate solution, just dry at 55-70°C.

Embodiment 2

[0026] Dissolve 0.5kg of maduromicin ammonium in 5kg of benzyl alcohol and set aside. Add 86.5kg of calcium carbonate and 13kg of nicarbazine into the fluidized bed, mix for 10 minutes, then spray into the benzyl alcohol solution of maduromycin ammonium, and dry at 55-75°C.

Embodiment 3

[0028] Dissolve 0.55 kg of maduromicin ammonium in 15 kg of 95% ethanol and set aside. Add 88.45kg of raw gypsum (passed through a 60-mesh sieve) into the fluidized bed, first fluidize and dry it, then add 11kg of nicarbazine into the fluidized bed, mix for 20 minutes, and finally spray into the madomecin Ammonium solution in 95% ethanol can be dried at 50-65°C.

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Abstract

The invention relates to a maduramicin ammonium nicarbazin premix and a preparation method thereof. The premix is prepared by dissolving maduramicin ammonium in a corresponding solvent, and then spraying the solution onto nicarbazin and an auxiliary material that are uniformly mixed in a fluidized bed. The solvent can be one or more of a 40%-95% ethanol solution, benzyl alcohol, ethyl acetate and the like. The auxiliary material can be selected from the following: corn starch, plaster stone, corncob powder, anhydrous glucose, talcum powder, and calcium carbonate, etc. The combined use of maduramicin ammonium and nicarbazin can achieve a synergistic anticoccidial effect, not only can inhibit coccidia growth, but also can kill coccidian. The premix is mainly used for prevention and control of chicken coccidiosis. The preparation method of the premix is simple and feasible, has a very good uniform mixing effect, and can effectively avoid various degrees of chicken poisoning phenomena caused by uneven mixing.

Description

technical field [0001] The invention relates to a formula and a preparation process for preventing and treating poultry coccidiosis, in particular to a maduromicin ammonium nicarbazine premix for preventing and treating chicken coccidiosis and a preparation method thereof. Background technique [0002] Coccidiosis is a common and very serious parasitic disease in chickens. It is an acute epidemic parasitic disease caused by one or more coccidiosis. The economic damage it caused was staggering. The morbidity and mortality of 10-30-day-old chicks or 35-60-day-old young chickens can be as high as 80%, generally 20-30%. Sick chickens are depressed, their feathers are fluffy, their heads are curled up, their appetite is poor, they have diarrhea, their feces are often bloody, and their production performance is reduced; the growth of sick chickens is hindered and their weight gain is slow; adult chickens generally do not suffer from disease, but they are infected with insects and...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61K9/14A61P33/02A61K31/505A61K31/17
Inventor 王树槐袁宝青李红娇石磊
Owner ZHENGZHOU FUYUAN ANIMAL PHARMA
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