Anti-anxiety medicament and preparation method thereof

An anti-anxiety and drug technology, applied in the field of medicine, can solve the problems of high price, large toxic and side effects, drug dependence and tolerance of new anti-anxiety drugs, and achieve the effects of saving auxiliary materials, convenient transportation and use, and anti-anxiety effect.

Active Publication Date: 2015-03-11
陕西中美天顺药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the anti-anxiety drugs used clinically are mainly benzodiazepines and non-benzodiazepines, but they have the disadvantages of relatively large toxic and side effects, drug dependence and tolerance, and the high price of new anti-anxiety drugs.

Method used

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  • Anti-anxiety medicament and preparation method thereof
  • Anti-anxiety medicament and preparation method thereof
  • Anti-anxiety medicament and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Embodiment 1: Capsules

[0024] By weight, flavescens: 18 parts; white peony root: 8 parts; sword bean: 4 parts.

[0025] Mix Sophora flavescens and Radix Paeoniae Alba and crush it into a coarse powder. Reflux the coarse powder with 8 times the weight of 60% ethanol for 2 hours, each time for 2 hours, filter after each reflux extraction, combine the filtrates to obtain an extract, extract After recovering ethanol from the liquid, it is dried under reduced pressure at 80°C to form a dry paste, and the dry paste is crushed into a fine powder; in addition, the sword bean is crushed into a fine powder, and mixed with the fine powder of the dry paste to obtain a pharmaceutical composition, and then the drug is added 1% magnesium stearate by weight of the composition is uniformly mixed, packed into capsules and packaged.

Embodiment 2

[0026] Embodiment 2: tablet

[0027] By weight, flavescens: 15 parts; white peony root: 10 parts; sword bean: 3 parts.

[0028] Mix Sophora flavescens and Radix Paeoniae Alba and crush it into a coarse powder. Reflux the coarse powder with 8 times the weight of 60% ethanol for 2 hours, each time for 2 hours, filter after each reflux extraction, combine the filtrates to obtain an extract, extract After recovering ethanol from the liquid, dry it under reduced pressure at 80°C to form a dry paste, and crush the dry paste into a fine powder; in addition, grind the sword bean into a fine powder, and mix it with the fine powder after the dry paste to obtain a pharmaceutical composition, and then use 70 % ethanol solution (containing 5% povidone) as a binder, pass through a 18-mesh sieve to make granules, dry, granulate, add 1% magnesium stearate, mix evenly, compress into tablets, and pack.

Embodiment 3

[0029] Embodiment 3: Granules

[0030] By weight, flavescens: 12 parts; white peony root: 14 parts; sword bean: 2 parts.

[0031] Mix Sophora flavescens and Radix Paeoniae Alba and crush it into a coarse powder. Reflux the coarse powder with 8 times the weight of 60% ethanol for 2 hours, each time for 2 hours, filter after each reflux extraction, combine the filtrates to obtain an extract, extract After recovering ethanol from the liquid, it is dried under reduced pressure at 80°C to form a dry paste, and the dry paste is crushed into a fine powder; in addition, the sword bean is crushed into a fine powder, and mixed with the fine powder of the dry paste to obtain a pharmaceutical composition, and then the drug is added Composition 1 times the weight of powdered sugar and 0.2 times the weight of dextrin, mixed evenly, using 70% ethanol solution as a wetting agent, granulated, dried and packaged.

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Abstract

The invention provides a medicine with anti-anxiety effect and a preparation method thereof: mix Sophora flavescens and Radix Paeoniae Alba, then pulverize, extract the powder under reflux with 60% ethanol, filter, and concentrate the filtrate under reduced pressure to obtain a dry cream, and the dry cream The powder is crushed into fine powder, and the sword bean is crushed into fine powder, and mixed evenly with dry ointment powder. The medicine of the invention has significant anxiolytic effect and no sedative effect, and the preparation process is simple and the cost is low.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a medicine with anti-anxiety effect and a preparation method thereof. Background technique [0002] Anxiety disorder is an emotional disorder characterized by persistent nervous worry, fear or episodic panic, accompanied by autonomic nervous system symptoms and behavioral characteristics such as restlessness. With the intensification of competition in modern society, the number of people suffering from anxiety disorders is on the rise. At present, the anti-anxiety drugs used clinically are mainly benzodiazepines and non-benzodiazepines, but they have the disadvantages of high toxicity and side effects, drug dependence and tolerance, and the high price of new anti-anxiety drugs. Contents of the invention [0003] The object of the present invention is to provide a medicine with anxiolytic effect and a preparation method thereof. [0004] In order to achieve the above object...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/71A61P25/22
Inventor 张亚军杨建宏戴贵东郑晓晖
Owner 陕西中美天顺药业有限公司
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