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Plaster for treating oral ulcer and preparation method of plaster

A technology for oral ulcer and film application, which is applied in the field of plant polysaccharide film and its preparation, to achieve obvious effects, convenient application, and shorten the healing time of ulcers

Inactive Publication Date: 2013-12-25
NANJING WILD PANT COMPREHENSIVE UTILIZATION INST THE ALL CHINA SUPPLY & MARKETING COOPERATIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] But so far, there is no such research report: both using Bletilla striata polysaccharide as the basic drug for treatment, and using it as a film-forming substrate for a film and a preparation method, to produce a kind of easy-to-use, fast-acting, curative effect. Good, safe, no side effects, low price, easy to treat oral ulcers and other trauma with pure natural polysaccharide film

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] Example 1: Preparation of Bletilla striata polysaccharide film

[0064] (1) Extraction of Bletilla striata polysaccharide: Grind the dry tuber product of Bletilla striata, pass through a 20-mesh sieve, weigh 100g of powder, add 1000mL of distilled water, extract at 70°C for 3 hours, and filter while hot to obtain the filtrate; repeat the extraction of the filter residue once more; combine The filtrate obtained twice was centrifuged, the supernatant was taken, and concentrated under reduced pressure to obtain about 60-70 mL of concentrated liquid. While stirring, add 180mL of 95% (v / m) ethanol and let it stand overnight; filter the precipitate, then add 80mL of 90% (v / m) ethanol to soak, filter, vacuum dry, pulverize, and pass through a 100-mesh sieve for later use.

[0065] (2) Preparation of glue solution: Dissolve 5g of Bletilla striata polysaccharide in 60mL of distilled water at 40°C and 100r / min under stirring. After it is completely dissolved, add 0.8g of glycer...

Embodiment 2

[0070] Example 2: Preparation of Bletilla striata polysaccharide film

[0071] (1) Extraction of Bletilla striata polysaccharide: Grind the dry tuber products of Bletilla striata, pass through a 40-mesh sieve, weigh 20kg of powder, add 150kg of distilled water, extract at 60°C for 2 hours, and filter while hot to obtain the filtrate; repeat the extraction of the filter residue once; combine Centrifuge the filtrate twice, take the supernatant, and concentrate under reduced pressure to obtain about 50-60L of concentrated liquid. While stirring, add 140L of 95% (v / m) ethanol and let it stand overnight; filter to obtain the precipitate, then add 60L of 90% (v / m) ethanol to soak, filter, and vacuum dry to obtain Bletilla striata polysaccharide. Crush and pass through a 100-mesh sieve for later use.

[0072] (2) Glue configuration: Dissolve 500g of Bletilla striata polysaccharide in 10L of distilled water at 50°C and 60r / min under stirring. Temperature -80, stir well to get glue...

Embodiment 3

[0077] Example 3: Preparation of Bletilla striata polysaccharide film

[0078] (1) Preparation of Bletilla striata polysaccharides: Grind the dried bletilla striata tubers, pass through a 12-mesh sieve, weigh 100g of powder, add 600mL of distilled water, heat and extract at 40°C for 3 hours, and filter while hot to obtain the filtrate; add distilled water to the filter residue and repeat Extract once; combine the two filtrates, centrifuge, take the supernatant, concentrate under reduced pressure to obtain a concentrate, add 180mL of 95% (v / m) ethanol under stirring, let it stand overnight, and filter to obtain the precipitate; add an appropriate amount of 90% % ethanol soaked, filtered to obtain wet Bletilla striata polysaccharide; vacuum dried and crushed to obtain Bletilla striata polysaccharide.

[0079] (2) Preparation of glue solution: Dissolve 4g of Bletilla striata polysaccharide in 100mL of distilled water at 40°C and 60r / min under stirring. After completely dissolvi...

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Abstract

The invention belongs to the technical field of biologic medicines, and relates to a plant polysaccharide plaster for treating oral ulcer and a preparation method of the plaster. The plaster is prepared from the formula with the following components in percentage by mass: 4-15% of bletilla striata polysaccharide, 0.1-0.4% of vitamin C, 0.0002-0.0005% of vitamin B12, 0.02-0.05% of vitamin E, 0.2-2% of glycerinum, 0.5-2% of tween-80 and the balance of distilled water, wherein vitamins refer to vitamin C, vitamin B12 and vitamin E, and the vitamins can not be added or one or two of the vitamins are added. The process comprises the following steps of crushing bletilla striata pieces, screening, extracting the bletilla striata polysaccharide by using a water extract and alcohol precipitate method, preparing a glue solution, filtering, degassing, cooling, forming a plaster, drying, dyestripping, shaping and packaging so as to obtain a finished product. The plaster has the characteristics that the use is convenient, the effect can be rapidly achieved, the curative effect is good, the plaster is safe and free of side effect, the price is low, and the like.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and relates to a plant polysaccharide film for mainly treating oral ulcers and a preparation method thereof. Background technique [0002] Oral ulcers are the most common oral mucosal disease Its symptoms are sores in the mouth, so it is also called aphthous ulcers. Its prevalence ranks first in oral mucosal diseases Epidemiological surveys in various countries have shown that at least 1 out of every 5 people has had oral ulcers. Patients often feel poor appetite because of this small problem, and because they feel that this kind of oral ulcer disease is small, they are unwilling to go to the hospital, so many patients often have oral ulcers that will not heal for a long time. [0003] At present, clinical treatment mostly advocates the combination of internal and external treatment, which is more commonly used to protect wounds, reduce inflammation and relieve pain, and promote ulcer he...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K31/736A61P1/02A61K36/898A61K125/00
Inventor 朱昌玲孙达锋张卫明
Owner NANJING WILD PANT COMPREHENSIVE UTILIZATION INST THE ALL CHINA SUPPLY & MARKETING COOPERATIV
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