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Preparation method of gold-loaded nanotube thin film on surface of medical titanium

A titanium oxide nanotube and nanotube technology, which is applied in surface reaction electrolytic coating, medical science, prosthesis, etc., can solve the problems of biological inertia and poor osseointegration ability, etc. Good protein affinity, good binding effect

Inactive Publication Date: 2013-12-18
SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The present invention is made to solve the problems of biological inertness and poor osseointegration ability of medical titanium materials in the prior art, and its purpose is to provide a method for preparing a gold nanotube film on the surface of medical titanium, which can In the case of ensuring the integrity of the titanium oxide nanotube array morphology, it is efficient and convenient to load nano-gold particles in the nanotubes, and effectively combine the nanotube morphology and the effect of nano-gold particles on cells and proteins to improve the osseointegration of medical titanium materials ability to fill gaps in existing technology

Method used

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  • Preparation method of gold-loaded nanotube thin film on surface of medical titanium
  • Preparation method of gold-loaded nanotube thin film on surface of medical titanium
  • Preparation method of gold-loaded nanotube thin film on surface of medical titanium

Examples

Experimental program
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Effect test

Embodiment 1

[0030] (1) After the medical titanium material is polished, it is ultrasonically cleaned with acetone, alcohol and deionized water for 30 minutes in order to obtain a clean and uniform surface;

[0031] (2) Preparation of anodic oxidation electrolyte: deionized water is used as solvent, and HF acid electrolyte with a volume percentage of 1.0% is prepared;

[0032] (3) Constant voltage DC anodizing technology is used to in-situ oxidize the surface of medical titanium materials to form regular titanium oxide nanotube array films. 20V, the oxidation time is 0.5 hours;

[0033] (4) After the preparation of the regular titanium oxide nanotube array film on the surface of medical titanium is completed, it is washed with absolute ethanol and deionized water for 5 minutes in sequence, and dried naturally;

[0034] (5) Preparation of chloroauric acid solution: use deionized water as the solvent, prepare a chloroauric acid solution with a concentration of 1mmol / L, and add 1mol / L sodium...

Embodiment 2

[0039] (1) After the medical titanium material is polished, it is ultrasonically cleaned with acetone, alcohol and deionized water for 30 minutes in order to obtain a clean and uniform surface;

[0040] (2) Preparation of anodic oxidation electrolyte: deionized water is used as solvent, and HF acid electrolyte with a volume percentage of 1.0% is prepared;

[0041] (3) Constant voltage DC anodizing technology is used to in-situ oxidize the surface of medical titanium materials to form regular titanium oxide nanotube array films. 20V, the oxidation time is 0.5 hours;

[0042] (4) After the preparation of the regular titanium oxide nanotube array film on the surface of medical titanium is completed, it is washed with absolute ethanol and deionized water for 5 minutes in sequence, and dried naturally;

[0043] (5) Preparation of chloroauric acid solution: use deionized water as the solvent, prepare a chloroauric acid solution with a concentration of 1mmol / L, and add 1mol / L sodium...

Embodiment 3

[0047] (1) After the medical titanium material is polished, it is ultrasonically cleaned with acetone, alcohol and deionized water for 30 minutes in order to obtain a clean and uniform surface;

[0048] (2) Preparation of anodic oxidation electrolyte: deionized water is used as solvent, and HF acid electrolyte with a volume percentage of 1.0% is prepared;

[0049] (3) Constant voltage direct current anodizing technology is used to in-situ oxidize the surface of medical titanium materials to form regular titanium oxide nanotube array films. The process parameters are: medical titanium is used as anode, graphite electrode or platinum electrode is used as cathode, and the anodizing voltage is 20V , the oxidation time is 0.5 hours;

[0050] (4) After the preparation of the regular titanium oxide nanotube array film on the surface of medical titanium is completed, it is washed with absolute ethanol and deionized water for 5 minutes in sequence, and dried naturally;

[0051] (5) Pr...

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Abstract

The invention relates to a preparation method of a gold-loaded nanotube thin film on the surface of medical titanium. The preparation method comprises the following steps: carrying out in-situ oxidation on the surface of medical titanium through constant voltage direct current anodic oxidation so as to generate a regular titanium oxide nanotube array thin film; adsorbing and loading chloroauric acid in titanium oxide nanotubes; soaking the titanium oxide nanotube array thin film in a solution which has the pH value of 7.0-8.0 and contains a chloroauric acid solution, standing still for 2 to 8 hours at the constant temperature of 37 DEG C, taking out, cleaning, and drying for 1 to 4 hours at the temperature of 50-80 DEG C so as to obtain the titanium oxide nanotube array thin film on which the chloroauric acid is adsorbed and loaded; and carrying out thermal treatment on the titanium oxide nanotube array thin film on which the chloroauric acid is adsorbed and loaded for 2 to 6 hours at 100-650 DEG C, thus obtaining the gold-loaded titanium oxide nanotube array thin film.

Description

technical field [0001] The invention relates to a method for preparing a gold nanotube film loaded on the surface of medical titanium, in particular to a method for in-situ oxidation of a titanium oxide nanotube film on the surface of medical titanium by means of a constant voltage direct current anodic oxidation process, and then adopts a wet chemical method to oxidize the gold nanotube film The invention relates to a method for loading particles into titanium oxide nanotubes so as to obtain gold-loaded nanotube films on the surface of medical titanium, belonging to the technical fields of nanomaterial preparation and metal material surface modification. Background technique [0002] The biological inertness of biomedical metal implants and the weak combination with bone tissue have always been the main problems restricting their clinical effects. Its poor osseointegration ability is mainly reflected in the fact that after implantation into human tissue, osteogenic proteins...

Claims

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Application Information

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IPC IPC(8): C25D11/26A61L27/42A61L27/30
Inventor 刘宣勇钱仕
Owner SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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