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Preparation method of carboxyl functionalized hyperbranched magnetic mesoporous silica composite microspheres

A technology of mesoporous silica and carboxyl functionalization, applied in the preparation of microspheres, microcapsule preparations, etc., can solve problems such as damage to healthy cells, adverse side effects, etc., and achieve effective and stable precious metal catalysts, high magnetic responsiveness, and good control effect. Effect

Inactive Publication Date: 2013-12-18
NORTHWESTERN POLYTECHNICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The drug kills a variety of tumor cells, but has the unwanted side effect of damaging other healthy cells

Method used

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  • Preparation method of carboxyl functionalized hyperbranched magnetic mesoporous silica composite microspheres
  • Preparation method of carboxyl functionalized hyperbranched magnetic mesoporous silica composite microspheres
  • Preparation method of carboxyl functionalized hyperbranched magnetic mesoporous silica composite microspheres

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Example 1: Superparamagnetic Fe 3 o 4 Preparation of nanoparticles

[0022] FeCl 3 ·6H 2 O (13.0g), trisodium citrate (5g) and sodium acetate (20g) were dissolved in 150ml ethylene glycol with the assistance of ultrasound, continued to stir for 1h under mechanical stirring, and transferred to three 50ml stainless steel PTFE high pressure In the reaction kettle, keep at 200°C for 10h. The product was washed 2 to 3 times with ethanol, and then washed with distilled water until neutral. Finally, the product was magnetically separated by an external magnetic field, and kept in a vacuum oven at 45°C for 24h.

Embodiment 2

[0023] Example 2: Magnetic core-shell Fe 3 o 4 nSiO 2 Preparation of composite microspheres

[0024] Ultrasonic disperse 0.6g superparamagnetic Fe3O4 nanoparticles in a mixture of 20ml pure water and 30ml absolute ethanol to form a uniform dispersion system, then quickly add 2ml NH 3 ·H 2 O, stirred mechanically at 300 rpm for 30 min, added 1.0 g of TEOS dropwise within 1 min, and kept stirring at room temperature for 10 h. The product was simply magnetically separated by an external magnetic field, washed several times with ethanol and distilled water, and finally kept in a vacuum oven at 45°C for 24h.

Embodiment 3

[0025] Example 3: Double-shell magnetic mesoporous Fe 3 o 4 nSiO 2 mSiO 2 Preparation of composite microspheres

[0026] 1.2g of the magnetic Fe prepared above 3 o 4 SiO 2 The core-shell composite microspheres and 3.6g template agent CTAB were ultrasonically dispersed in a mixture of 80ml pure water and 160ml absolute ethanol to form a uniform dispersion system, and then 8ml NH 3 ·H 2 O, mechanically stirred at 300 rpm for 30 min. The rotational speed was adjusted to 360 rpm, 4.0 g of TEOS was added dropwise within 3 min, and the reaction was kept stirring at room temperature for 10 h. The product was simply magnetically separated by an external magnetic field, washed several times with ethanol and distilled water, and finally kept in a vacuum oven at 45°C for 24h.

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Abstract

The invention relates to a preparation method of carboxyl functionalized hyperbranched magnetic mesoporous silica composite microspheres which are suitable for packaging anticancer drugs and loading noble metal nano-catalysts. By selecting magnetic Fe3O4 nanoparticles prepared by a hydrothermal method as a magnetic core, a surfactant CTAB (Cetyltrimethyl Ammonium Bromide) as a template and TEOS (Tetraethyl Orthosilicate) as a silicon source, magnetic double-shell mesoporous silica composite microspheres with relatively high magnetic responsiveness, strong stability and high specific surface area and pore volume are successfully prepared through a conventional hydrolysis method. Application of the microspheres in aspects of loading and controlled release of DOX (Doxorubicin), loading of noble metal nano-catalysts and the like is studied, thereby representing an expected superior effect. According to the preparation method provided by the invention, in consideration of hyperbranched structures and terminal carboxyl functional groups with the stereo-hindrance effect contained in mesoporous ducts, the material has important meaning in cancer therapy and organic synthesis of the noble metal nano-catalysts.

Description

technical field [0001] The invention relates to the preparation of carboxyl-functionalized hyperbranched magnetic mesoporous silica composite microspheres suitable for encapsulation of anticancer drugs and loading of noble metal nanocatalysts. The hyperbranched structure with a large number of terminal hydroxyl groups is introduced into the The surface of the magnetic mesoporous silica composite microsphere and the mesoporous channel, and then the hydroxyl group at the end of the hyperbranched chain is modified to make it suitable for the encapsulation of anticancer drugs and the application of slow release and loading precious metal nanocatalysts. Background technique [0002] Doxorubicin hydrochloride (DOX) is a commonly used antitumor antibiotic and an effective DNA intercalation agent, which can effectively control the proliferation of cancer cells by inhibiting the synthesis of nucleic acid in the genetic material of cancer cells. The drug kills many types of tumor cell...

Claims

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Application Information

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IPC IPC(8): B01J13/02
Inventor 张秋禹李伟张宝亮张和鹏
Owner NORTHWESTERN POLYTECHNICAL UNIV
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