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Clarithromycin capsule and preparation method thereof

A technology of clarithromycin and production method, which is applied in capsule delivery, pharmaceutical formula, medical preparations of non-active ingredients, etc., and can solve problems such as difficulty in finding parameters and changes

Inactive Publication Date: 2013-12-18
上海海虹实业(集团)巢湖今辰药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, during the production process, auxiliary materials also bring about large changes in the parameters of production equipment such as fluidized drying granulators, and it is difficult to find suitable parameters

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] The internal components of clarithromycin capsules are composed of clarithromycin with a weight ratio of 250:0.75:20:0.5, sodium lauryl sulfate as a cosolvent, polyethylene glycol 6000 as a binder and filler, as The glidant consists of magnesium stearate.

[0015] Get clarithromycin 250g, sodium lauryl sulfate 0.75g, macrogol 6000 20g, magnesium stearate 0.5g, make 1000 clarithromycin capsules.

[0016] During preparation: take the clarithromycin raw material of the prescribed amount, mix it with polyethylene glycol 6000 and sodium lauryl sulfate in the prescribed amount, melt and granulate it, mix the granules with magnesium stearate evenly, and fill it into hollow capsules ; After polishing the residual powder on the shell of the capsule, the finished product is packaged.

[0017] Technological process: 1. Raw materials and auxiliary materials - batching, weighing, 2. Granulation - whole grains, blending, 3. Granules - filling, polishing (inspection), 4. Bulk capsule...

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PUM

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Abstract

The invention discloses a clarithromycin capsule and a preparation method thereof. The clarithromycin capsule comprises following internal components: clarithromycin, lauryl sodium sulfate serving as a cosolvent, polyethylene glycol 6000 serving as an adhesive and a filling agent, and magnesium stearate serving as a flow aid, which are under in the weight ratio of 250: 0.75: 20: 0.5. The preparation method comprises the following steps of: taking clarithromycin as the raw material based on the dose as indicated in a formula; uniformly mixing with polyethylene glycol 6000 and lauryl sodium sulfate with the dose as indicated in the formula; fusing and pelleting; uniformly mixing the particles with magnesium stearate; filling into a hollow capsule; removing residual powder on a housing of the capsule; and packing to obtain the finished product of clarithromycin capsule.

Description

technical field [0001] The invention relates to a capsule and a preparation method thereof, in particular to a clarithromycin capsule and a preparation method thereof. Background technique [0002] Clarithromycin capsules are relatively common drugs currently on the market. The main drug is clarithromycin, and the rest are auxiliary materials. The difference in the selection of excipients has many effects on the production process of clarithromycin capsules and the long-term storage of clarithromycin in the capsules, so careful selection is required. In addition, during the production process, auxiliary materials also bring about large changes in the parameters of production equipment such as fluidized drying granulators, and it is difficult to find suitable parameters. Contents of the invention [0003] The invention provides a clarithromycin capsule capable of maintaining the drug properties of the main drug clarithromycin for a long time and a preparation method thereo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K31/7048A61K47/34A61P31/04
Inventor 梁延波蒋小云沈浩黄斌
Owner 上海海虹实业(集团)巢湖今辰药业有限公司
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