A kind of etoposide implant
A technology of etoposide and implants, which is applied in the composition and size of etoposide implants, etoposide implants and their preparation, drug release characteristics and preparation, and shape fields, which can solve the problems of multiple prescription ingredients, Complex process and other issues, to achieve the effect of small systemic adverse reactions, simple preparation process and good stability
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0046] Embodiment 1 prepares etoposide implant (A)
[0047]
[0048] Crush the above materials respectively, pass etoposide and polylactic acid through a 120-mesh sieve, and polyethylene glycol through a 200-mesh sieve, weigh and mix according to the prescription amount, a total of 5g, mix evenly in a mixer, oscillate and load into a 0.9mm aperture The 141-hole stainless steel mold was placed in a ZR-II drug press machine (developed by Anhui Zhongren Technology Co., Ltd.), pressed at 320Mpa, and demolded to obtain the etoposide implant (A).
[0049] The implant is easy to demold, has a smooth surface, a diameter of 0.9mm, a length of 1.2mm, a strength of 5.6MPa, and 90% of the drug release time is 10 days, see Example 4 and figure 1 .
Embodiment 2
[0050] Embodiment 2 prepares etoposide implant (B)
[0051]
[0052] Except that the pressure of the medicine pressing machine was 410Mpa, the rest of the preparation process was the same as in Example 1 to obtain the etoposide implant (B).
[0053] The implant is easy to demould, has a smooth surface, a diameter of 0.9mm, a length of 1.9mm, a strength of 9.5MPa, and a 90% release time of 36 days, see Example 4 and figure 1 .
Embodiment 3
[0054] Embodiment 3 prepares etoposide implant (C)
[0055]
[0056] Except that the pressure of the medicine pressing machine was 480Mpa, the rest of the preparation process was the same as in Example 1 to obtain the etoposide implant (C).
PUM
Property | Measurement | Unit |
---|---|---|
diameter | aaaaa | aaaaa |
diameter | aaaaa | aaaaa |
diameter | aaaaa | aaaaa |
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com