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Production technology of pharmaceutical grade sodium alginate

A sodium alginate and production process technology, which is applied in the field of marine chemical product preparation, can solve the problems of low calcium content and low heavy metal content, and achieve the effects of low calcium and heavy metal content, good fluidity, and guaranteed purity

Active Publication Date: 2013-10-16
青岛海之林生物科技开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Aiming at the problems existing in the existing sodium alginate production process, the present invention proposes a production process for pharmaceutical grade sodium alginate with low heavy metal, low endotoxin and low viscosity. Containing endotoxin, viscosity similar to pure water, high purity, good stability, good fluidity, low calcium content, especially suitable for the use of plasma substitutes in medicine

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] 1) Soaking and washing: Soak 1000kg of dried kelp in 15t of water for 1 hour, cut into strips of about 10 cm, and wash the kelp strips countercurrently with 30t of water several times until they are clean.

[0027] 2) Digestion: Put the washed kelp strips into the digestion tank, add 30kg of compound salt, and let it sit for 4 hours at a constant temperature of 60°C, then mechanically break the kelp into viscous sodium alginate mud;

[0028] Wherein the compound salt is made up of sodium carbonate, sodium tripolyphosphate, sodium hexametaphosphate, disodium EDTA, wherein the weight percentages of sodium carbonate, sodium tripolyphosphate, sodium hexametaphosphate, disodium EDTA are successively: sodium carbonate 70%, Sodium tripolyphosphate 12%, sodium hexametaphosphate 10%, disodium EDTA 8%;

[0029] 3) Dilution: Dilute the sodium alginate sludge with 100t of water equivalent to the weight of dry kelp raw materials, and digest the residue after recovery;

[0030] 4) F...

Embodiment 2

[0042] 1) Soaking and washing: Soak 1000kg of dried kelp in 15t of water for 1 hour, cut into strips of about 10 cm, and wash the kelp strips countercurrently with 30t of water several times until they are clean.

[0043] 2) Digestion: Put the washed kelp strips into the digestion tank, add 50kg of compound salt, let it sit for 4 hours at a constant temperature of 60°C, and break the kelp into viscous sodium alginate mud by machinery;

[0044] Wherein the compound salt is made up of sodium carbonate, sodium tripolyphosphate, sodium hexametaphosphate, disodium EDTA, wherein the weight percentages of sodium carbonate, sodium tripolyphosphate, sodium hexametaphosphate, disodium EDTA are successively: sodium carbonate 75%, Sodium tripolyphosphate 10%, sodium hexametaphosphate 10%, disodium EDTA 5%;

[0045] 3) Dilution: Dilute the sodium alginate sludge with 100t of water equivalent to the weight of dry kelp raw materials, and digest the residue after recovery;

[0046] 4) Foamin...

Embodiment 3

[0057] 1) Soaking and washing: Soak 1000kg of dried kelp in 15t of water for 1 hour, cut into strips of about 10 cm, and wash the kelp strips countercurrently with 30t of water several times until they are clean.

[0058] 2) Digestion: Put the washed kelp strips into the digestion tank, add 40kg of compound salt, and let it sit for 4 hours at a constant temperature of 60°C, then mechanically break the kelp into viscous sodium alginate mud;

[0059] Wherein the compound salt is made up of sodium carbonate, sodium tripolyphosphate, sodium hexametaphosphate, disodium EDTA, wherein the weight percentages of sodium carbonate, sodium tripolyphosphate, sodium hexametaphosphate, disodium EDTA are successively: sodium carbonate 75%, Sodium tripolyphosphate 9%, sodium hexametaphosphate 8%, disodium EDTA 8%;

[0060] 3) Dilution: Dilute the sodium alginate sludge with 100t of water equivalent to the weight of dry kelp raw materials, and digest the residue after recovery;

[0061] 4) Foa...

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Abstract

The invention provides a production technology of pharmaceutical grade sodium alginate with low a heavy metal content, a low endotoxin content and low viscosity. The technology aims at solving the problems existing in the existing production technology of sodium alginate. Sodium alginate produced by the technology is very low in heavy metal content, and hardly contains endotoxin; and the viscosity of sodium alginate is similar to that of pure water; and sodium alginate is high in purity, good in stability and liquidity, and low in calcium content, and is especially suitable for replacing plasma in medicine.

Description

technical field [0001] The invention belongs to the technical field of preparation of marine chemical products, and in particular relates to a production process of pharmaceutical-grade sodium alginate, that is, a production process of low-heavy metal, low-endotoxin and low-viscosity sodium alginate. Background technique [0002] Sodium alginate is a natural polymer material extracted from seaweed. It has good thickening, emulsifying, stabilizing and gelling effects, and is widely used in medicine, food, industry, daily chemical and other fields. At present, the sodium alginate used in pharmaceutical-grade plasma must require low endotoxin, low heavy metals, ultra-low viscosity, and very high specifications. Although the quality of domestically produced sodium alginate can basically reach the international level, due to the influence of sea areas and processing technology , heavy metals are heavily enriched in domestic artificially cultivated brown algae plants; some metal e...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/04
Inventor 陈宏刘兴勇刘晶营崔冰李朋
Owner 青岛海之林生物科技开发有限公司
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