Method for preparing globular porous calcium carbonate granules

A porous calcium carbonate, particle technology, applied in calcium carbonate/strontium/barium, nanotechnology for materials and surface science, nanotechnology, etc., can solve the problem of large size distribution of calcium carbonate powder, harsh and complex preparation conditions, and poor uniformity and other problems, to achieve the effects of mild and controllable preparation conditions, good biocompatibility and uniform size

Active Publication Date: 2013-10-16
ZHEJIANG SCI-TECH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, most of the technologies have the problems of harsh and complex preparation conditions and high energy consumption. At the same time, the prepared calcium carbonate powder has a large size distribution and poor uniformity. It is urgent to develop new simple and low energy consumption preparation technologies and methods.

Method used

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  • Method for preparing globular porous calcium carbonate granules
  • Method for preparing globular porous calcium carbonate granules
  • Method for preparing globular porous calcium carbonate granules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Arginine solution, 60 mM calcium chloride solution, and 60 mM sodium carbonate solution were respectively prepared with a mass fraction of 2%. First, 40 mL of arginine solution and sodium carbonate solution were mixed at a volume of 1:1 to form Mix the solution; then, under the condition of stirring at 600 rpm, add the mixed solution of sodium carbonate dropwise to 200 mL of calcium chloride solution through a constant flow pump; continue vigorously stirring for 15 min after the addition is completed; wait for the reaction After completion, centrifuge at 3000 rpm for 5 min to collect the particle precipitate, and wash it several times with absolute ethanol and deionized water; finally, put it in a constant temperature oven at 60°C and dry it overnight to collect the nano-calcium carbonate particle powder.

[0031] The nano-calcium carbonate particle powder is composed of nano-calcium carbonate with a diameter of 150-250 nm, has a spherical shape, has a loose porous struc...

Embodiment 2

[0034] Arginine solution, 40 mM calcium nitrate solution, and 40 mM sodium carbonate solution were respectively prepared with a mass fraction of 2%; first, 40 mL of arginine solution and sodium carbonate solution were mixed at a volume of 1:1 to form a mixed solution; then, under the condition of stirring at 300rpm, the sodium carbonate mixed solution was added dropwise into 200 mL of calcium chloride solution through a constant flow pump; after the dropwise addition was completed, continue to stir vigorously for 15 min; after the reaction was completed, The pellet was collected by centrifugation at 4000 rpm for 3 min, and washed several times with absolute ethanol and deionized water; finally, it was dried overnight in a constant temperature oven at 60°C to collect nano calcium carbonate particle powder.

Embodiment 3

[0036] Arginine solution, 60 mM calcium nitrate solution, and 60 mM sodium carbonate solution with a mass fraction of 1% were respectively prepared; first, 40 mL of arginine solution and sodium carbonate solution were mixed at a volume of 1:1 to form a mixed solution; then, under the condition of stirring at 500 rpm, the sodium carbonate mixed solution was added dropwise into 200 mL of calcium chloride solution through a constant flow pump; after the addition was completed, continue to stir vigorously for 15 min; after the reaction was completed Finally, the pellet was collected by centrifugation at 3500 rpm for 5 min, and washed several times with absolute ethanol and deionized water; finally, it was dried overnight in a constant temperature oven at 60°C to collect nano calcium carbonate particle powder.

[0037] The nano-calcium carbonate particle powder that embodiment 2 and 3 obtains all has the technical parameter identical with the nano-calcium carbonate particle powder t...

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Abstract

The invention discloses a method for preparing globular porous calcium carbonate granules and belongs to the technical field of a preparation method of nano calcium carbonate granules. The method comprises the following processing steps: respectively preparing arginine solution, calcium source solution and sodium carbonate solution; mixing the arginine solution with the sodium carbonate solution to obtain mixed solution; dropwise adding the mixed solution to the calcium source solution under the condition of vigorous stirring; then, continuing to vigorously stir after the dropwise addition, centrifugally collecting granule sediments after reaction is finished; and washing the granule sediments by deionized water and absolute ethyl alcohol, and then drying, so as to obtain nano calcium carbonate granule powder. The method disclosed by the invention is simple in preparation process, strong in laboratory maneuverability, low in production cost, high in product yield, and suitable for research and application of the laboratory and industrial production; and the prepared globular granules have the advantages of good dispersibility, large specific surface area and the like. Therefore, the prepared globular granules have great application potential in the fields of biomedicine and biological materials, such as controlled-release drug carriers, gene therapy vectors and the like.

Description

technical field [0001] The invention belongs to the technical field of preparation methods of nano calcium carbonate particles, in particular to a method for preparing spherical porous calcium carbonate particles. Background technique [0002] Calcium carbonate nano- or micron-sized particles or microspheres have extensive and important uses in the fields of coatings, medicine, and pharmacy. Moreover, calcium carbonate can be used as an inorganic material with good tissue compatibility and no side effects, and can be used as an excellent drug slow-release carrier and gene delivery carrier. [0003] Therefore, how to easily prepare nano-calcium carbonate with nanometer size and large loading capacity has become one of the focus issues of research. At present, there are many mature technologies to prepare and produce calcium carbonate powders with different structures and shapes, such as J.F.Chen, Y.H.Wang, F.Guo, X.M.Wang and C.Zheng (Synthesis of Nanoparticles with Novel Te...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01F11/18B82Y30/00
Inventor 孔祥东韩华锋赵瑞波李泽豪陈侃任小元
Owner ZHEJIANG SCI-TECH UNIV
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