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Choline chloride water dispersible granule/tablet and preparation method thereof

A technology of choline chloride and dispersible granules, which is applied in botany equipment and methods, biocides, animal repellents, etc., can solve the problems of inaccurate use of water agents, small powder particles, and easy drift, etc., and it is not easy to achieve The effects of phytotoxicity, fast disintegration, and simple preparation process

Inactive Publication Date: 2013-10-16
安阳全丰生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the small size of the powder, it is easy to drift, which brings many adverse effects to the operator and the surrounding environment during the production and use; the water agent has problems such as inaccurate use and measurement

Method used

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  • Choline chloride water dispersible granule/tablet and preparation method thereof
  • Choline chloride water dispersible granule/tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] The preparation of embodiment 1 5% choline chloride water-dispersible granules

[0033] The selection and proportioning of the original drug and auxiliary agents are: 95% choline chloride original drug 5.3% (5.0%), the dispersant is sodium methylene bismethyl naphthalene sulfonate 2.0%, calcium lignosulfonate 4.0% %, wetting agent sodium lauryl sulfate 2.0%, disintegrant ammonium sulfate 15.0%, binder is gum arabic 3.0%, filler is attapulgite make up 100%

[0034] According to the above proportions, the dosage of each component is calculated, weighed, and mixed evenly; the formula is granulated by ultrafine / jet milling, dried, granulated, and selected. Product testing is carried out according to the quality control indicators of water-dispersible granules, including the content of active ingredients, wetting time, disintegration rate, foaming property, sieve analysis, shedding rate, pH range and thermal storage stability, etc. The specific method is as follows:

[003...

Embodiment 2

[0041] The preparation of embodiment 2 5% choline chloride water-dispersible tablet

[0042] The selection and proportioning of the former drug and the auxiliary agent are: 95% choline chloride former drug 5.3% (5.0%), the dispersant is 3.0% of naphthalenesulfonate formaldehyde condensate, 3.0% of sodium lignosulfonate, moistening agent Wet agent sodium dodecylbenzene sulfonate 2.0%, disintegrating agent is ammonium sulfate 17.0%, binder is polyvinyl alcohol 5.0%, filler is talcum powder to make up 100%.

[0043] According to the above proportions, the dosage of each component is calculated, weighed, and mixed evenly; the formula is granulated by ultrafine / jet milling, dried, pressed into tablets, and selected. Product testing is carried out according to the quality control indicators of water-dispersible tablets, including the content of active ingredients, disintegration time limit, foaming property, sieve analysis, powder and fragment rate, pH range and thermal storage stab...

Embodiment 3

[0051] The preparation of embodiment 3 10% choline chloride water dispersible granules

[0052] The selection and proportioning of the original drug and auxiliary agent are: 95% choline chloride original drug 10.7% (10.0%), the dispersant is 5.0% sodium methylene bismethyl naphthalene sulfonate, and the wetting agent is twelve Sodium alkylbenzene sulfonate is 3.0%, the disintegrant is sodium carboxymethyl starch 16%, the binder is sodium carboxymethylcellulose 3.0%, and the filler is kaolin to make up 100%. The specific preparation process is the same as in Example 1.

[0053] The assay method of each performance index of the choline chloride water-dispersible granule prepared in embodiment 3 is the same as embodiment 1. The specific measurement results are: choline chloride content 10.1%, wettability qualified (22 seconds), disintegration qualified (48 seconds), foaming property qualified (24 milliliters), moisture 1.0%, shedding rate 0.8%, pH value 7.1, sieve analysis 99%,...

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Abstract

The invention discloses a choline chloride water dispersible granule / tablet and a preparation method thereof. The choline chloride water dispersible granule / tablet comprises, by mass, 0.1-80% of choline chloride, 0.5-16% of a dispersant, 0.5-9% of a wetting agent, 0.5-25% of a disintegrating agent, 0-12% of a binder, and the balance filler. The preparation method of the granule / tablet comprises the following steps: mixing all the above raw materials composing the choline chloride water dispersible granule / tablet, carrying out ultramicro / airflow crushing, granulating, drying, granulating / tabletting, carefully choosing, and detecting. The choline chloride water dispersible granule / tablet has the advantages of safety to the environment, humans, animals and other beneficial organisms, difficult generation of the phytotoxicity, metering accuracy, use convenience, fast disintegration speed, good storage stability, and simple preparation technology, and is suitable for the industrialized production and the agricultural large-area popularization application.

Description

Technical field: [0001] The invention relates to a water-dispersible granule / tablet of a plant growth regulator and a preparation method thereof, in particular to a choline chloride water-dispersible granule / tablet and a preparation method thereof. Background technique: [0002] Choline chloride can be absorbed by plant stems, leaves, and roots, and then transmitted to the active parts. Its physiological effects can inhibit the photorespiration of some plants, promote root development, and allow photosynthetic products to accumulate as much as possible in tubers and roots. In order to increase production and improve varieties. As a plant growth regulator, it is mainly used in crops such as sweet potato, rice, cabbage, radish, apple, peach, grape, potato, soybean and corn. It can not only increase the yield of crops, but also improve their quality. [0003] Structural formula: [0004] [0005] Molecular formula: HOCH 2 CH 2 N(CH 3 ) 3 Cl [0006] English common nam...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N33/12A01N25/14A01N25/34A01P21/00
Inventor 徐雪松杨晓庆晋艳芳
Owner 安阳全丰生物科技有限公司
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