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Application of biphenol and/or derivatives thereof in preparation of drugs for inhibiting cancer cell metastasis

A technology of biphenol and its derivatives, which is applied in the field of application of biphenol and/or its derivatives in the preparation of drugs for inhibiting cancer cell metastasis, can solve the problems of few cancer cells, etc., and achieve inhibition of metastasis, good Application prospect, low toxicity effect

Inactive Publication Date: 2013-09-25
SHANGHAI PULMONARY HOSPITAL
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  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

But so far there are few reports that magnolol, honokiol and their derivatives mediate the metastasis of cancer cells

Method used

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  • Application of biphenol and/or derivatives thereof in preparation of drugs for inhibiting cancer cell metastasis
  • Application of biphenol and/or derivatives thereof in preparation of drugs for inhibiting cancer cell metastasis
  • Application of biphenol and/or derivatives thereof in preparation of drugs for inhibiting cancer cell metastasis

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Embodiment Construction

[0032] Referring to the accompanying drawings, the present invention will be further described in conjunction with specific embodiments, so as to better understand the present invention.

[0033] The methods used in the following examples are conventional methods unless otherwise specified.

[0034] 1. Cancer cell culture

[0035] Lung cancer 95D cell line and H460 cell line (American Type Culture Collection) were cultured in DMEM medium containing 10% fetal bovine serum, 100 mg / mL streptomycin and 100 U / mL penicillin, and the culture condition was 5% CO 2 The temperature was 37°C, and fresh medium was replaced every 2-3 days; then cultured in DMEM medium without fetal bovine serum for 24 hours to obtain 95D cells and H460 cells.

[0036] 2. Cancer cell proliferation experiment in vitro

[0037] The obtained cancer cells were inoculated on a 96-well cell culture plate, and different concentrations of magnolol (0, 6.25, 12.5, 25, 50 or 100 μM) were added. After culturing for ...

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Abstract

The invention discloses application of biphenol and / or derivatives thereof in preparation of drugs for inhibiting metastasis of cancer cells, wherein the biphenol is magnolol and / or honokiol. The cancer cells are one or a plurality kinds of cells from cells of brain tumor, blood tumor, esophageal cancer, liver cancer, skin cancer, prostate cancer, bone cancer, breast cancer and lung cancer. One novel application of the magnolol, the honokiol and derivatives of both are provided. The magnolol and the like can effectively inhibit cell adhesion, migration, invasion and expression of MMP-2, so that the magnolol and the like can effectively inhibit the metastasis of the cancer cells. The magnolol, the honokiol and the derivatives of both have low toxicity, almost no toxic and harmful effect on human normal cells, and good clinical anti-tumor application prospects.

Description

technical field [0001] The present invention relates to the application of biphenol and / or derivatives thereof in the preparation of anticancer drugs, in particular to the application of biphenol and / or derivatives thereof in the preparation of drugs for inhibiting cancer cell metastasis. Background technique [0002] Tumor is one of the diseases that seriously threaten human health. It is the second largest killer of human beings after cardiovascular disease, and it is also one of the important social problems faced by countries all over the world. Statistics show that in 2006, 3 million people died of cancer in my country, and the incidence of cancer is still on the rise. According to statistics, in less than 20 years, the incidence of cancer in my country has increased by 69%, and the mortality rate has increased by 29.4%. [0003] At present, there are many methods such as surgery, radiotherapy, chemotherapy and new biological therapy to control the growth and metastasi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/05A61P35/04A61P35/00A61P35/02
Inventor 刘根桃王和勇伍春莲
Owner SHANGHAI PULMONARY HOSPITAL
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