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Metoclopramide nasal spray

A metoclopramide nasal and spray technology, applied in therapeutic nebulizers and other directions, can solve the problems of increasing the economic burden of patients, less effective spraying times, and increasing the waste of liquid medicine, so as to reduce filling Equipment requirements, mature processing technology, and cost-saving effects

Inactive Publication Date: 2013-09-11
北京天衡药物研究院有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Disadvantages: inconvenient injection administration, poor patient tolerance
[0005] The metoclopramide nasal spray of Crinos listed in Italy is to fill the liquid medicine in an ordinary spray bottle. Due to the large volume of the spray bottle, the small volume of liquid medicine (2.0ml) only exists in the spray bottle. At the bottom, the liquid level is low, and the depth of the immersion pipette is insufficient, resulting in incomplete absorption of the liquid medicine, resulting in less effective spraying times, more residues, and large waste. Although the effective spraying can be solved by increasing the filling volume of the liquid medicine The defect of insufficient number of liquids, but further increases the waste of expensive liquids, resulting in high drug prices and increasing the financial burden on patients

Method used

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  • Metoclopramide nasal spray

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] 1. Prescription (based on 1000 bottles, 50μl / spray, 10mg / spray)

[0048]

[0049] Second, the preparation process:

[0050] 1. Dosing: Weigh the raw and auxiliary materials of the prescription amount into water of 95% of the prescription amount, stir to dissolve them, add water to make up the volume, and get ready.

[0051] 2. Filling: Fill the aqueous solution of metoclopramide prepared above into the attached figure 2 In the spray bottle shown, fill each bottle with 2.5ml, tighten the spray head (50μl / spray, 10mg / spray), that is, the final product is shown in the attached Figure 4 .

[0052] 3. Tests of effective spray times, spray uniformity and spray residual rate

[0053] The content of main ingredient per spray: same as comparative example

[0054] Reference substance solution preparation: with comparative example

[0055] Residual main drug content in the bottle:

[0056] Take out all the residual liquid in the spray bottle, dilute it into a 50ml measu...

Embodiment 2

[0069] 1. Prescription (based on 1000 bottles, 10mg / spray)

[0070]

[0071] Second, the preparation process:

[0072] 1. Dosing: Weigh the raw and auxiliary materials of the prescription amount into water of 95% of the prescription amount, stir to dissolve them, add water to make up the volume, and get ready.

[0073] 2. Filling: Fill the aqueous solution of metoclopramide prepared above into the attached image 3 In the spray bottle shown, fill each bottle with 2.5ml, tighten the spray head (50μl / spray, 10mg / spray), that is, the final product is attached Figure 5 .

[0074] 3. Tests of effective spray times, spray uniformity and spray residual rate

[0075] The content of main ingredient per spray: same as comparative example

[0076] Reference substance solution preparation: with comparative example

[0077] Residual main drug content in the bottle:

[0078] Take out all the residual liquid in the spray bottle, dilute it into a 250ml measuring bottle with mobile p...

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Abstract

The invention provides a metoclopramide nasal spray. A used spraying device comprises a spray bottle and a spray head, and is characterized in that the spray bottle comprises a casing (1) and a liner (2) with 3.0 ml volume; the liner of the spray bottle is in a shape of a cylinder, the combination of a cylinder and a conoidcone, or the combination of a cylinder, a conoidcone and a cylinder with a smaller diameter; the casing of the spray bottle is provided with the same shape, size and interface part with a spray bottle of a 10 ml spraying agent device sold in the market presently; and the spray head adopts a spray head of the 10 ml spraying agent device sold in the market presently. The metoclopramide nasal spray provided by the invention has the advantages of few residues, high safety and multiple times of effective spraying, the production cost can be reduced, and the medicine waste is prevented.

Description

Technical field: [0001] The invention relates to a metoclopramide nasal spray, in particular to a metoclopramide nasal spray using a spray bottle with a volume of 3.0ml of an inner container. Background technique: [0002] Metoclopramide as dopamine D 2 Receptor antagonist, also has 5-HT 4 Receptor agonism, on 5-HT 3 Receptors are slightly inhibited. It can act on dopamine receptors in the medullary emetic chemoreceptor zone (CTZ) to increase the threshold of CTZ, and has a strong central antiemetic effect. The drug mainly acts on the upper gastrointestinal tract, promoting the movement of the stomach and upper intestinal segment; increasing the tension of the gastrointestinal sphincter in the resting state, increasing the tension and contraction of the lower esophageal sphincter, increasing the pressure at the lower end of the esophagus, and blocking the stomach- Esophageal reflux, strengthen gastric and esophageal peristalsis, and enhance the ability to clear out esoph...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M11/00
Inventor 姜庆伟衣伟锋吕玉珠唐亚坤刘俊轶
Owner 北京天衡药物研究院有限公司
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