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Preparation method of modified silicone rubber

A technology of modifying silicon and silicone rubber, which is applied in medical science, surgery, etc., and can solve the problems of endometrial trauma, pain, and other diseases easily

Inactive Publication Date: 2013-09-11
刘芳
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, after intrauterine adhesion treatment operation, the endometrium is traumatized to a greater degree, and the recovery is relatively slow, and long-term oral administration of drugs that help endometrium recovery will cause increased treatment costs and physical harm to the implanter. pain, and easily lead to the occurrence of other diseases

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Using silicone rubber as the raw material, add 0.1wt% estrogen, stir at room temperature for 5 minutes, mix well, then add the mixed vulcanizing agent into the mixing system, keep stirring for 5 minutes, then spread the film under the plate glass, dry, and finally in 100 After vulcanization under the condition of ℃, it is cooled with the furnace. The silicone rubber material prepared by the present invention that can promote postoperative endometrial recovery is implanted in animals, and the area of ​​the uterine cavity wall covered by the newborn endometrial tissue at 10 days is measured, and the results show that the implanted silicone rubber with estrogen added The speed of endometrial recovery was increased by 1% compared to the implantation of silicone rubber without added estrogen. The area of ​​the uterine cavity wall covered by the new endometrial tissue at 30 days was measured, and the results showed that the implantation of estrogen-added silicone rubber incre...

Embodiment 2

[0015] Use silicone rubber as raw material, add 5wt% estrogen, stir at room temperature for 15 minutes, mix well, then add mixed vulcanizing agent into the mixing system, keep stirring for 15 minutes, then lay a film under a flat glass, dry, and finally at 200 ° C After vulcanization under certain conditions, it is cooled with the furnace. The silicone rubber material prepared by the present invention that can promote postoperative endometrial recovery is implanted in animals, and the area of ​​the uterine cavity wall covered by the newborn endometrial tissue at 10 days is measured, and the results show that the implanted silicone rubber with estrogen added The endometrium repaired 10% faster than implants with silicone rubber without added estrogen. The area of ​​the uterine cavity wall covered by neonatal endometrial tissue at 50 days was measured, and the results showed that the implantation of estrogen-added silicone rubber increased the speed of endometrial recovery compa...

Embodiment 3

[0017] Use silicone rubber as the raw material, add 15wt% estrogen, stir at room temperature for 30 minutes, mix well, then add the mixed vulcanizing agent into the mixing system, keep stirring for 20 minutes, then spread the film under the flat glass, dry, and finally at 300 ° C After vulcanization under certain conditions, it is cooled with the furnace. The silicone rubber material prepared by the present invention that can promote postoperative endometrial recovery is implanted in animals, and the area of ​​the uterine cavity wall covered by the newborn endometrial tissue at 10 days is measured, and the results show that the implanted silicone rubber with estrogen added The endometrium recovered 18% faster compared to implants that had no added estrogen. The area of ​​the uterine cavity wall covered by the new endometrial tissue at 60 days was measured, and the results showed that the implantation of estrogen-added silicone rubber increased the speed of endometrial recovery...

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Abstract

The invention discloses a preparation method of modified silicone rubber. The method comprises the following steps: by using silicone rubber as a raw material, adding 0.1-20wt% of estrogen, stirring for 5-30 minutes at room temperature, and uniformly mixing; then, adding a mixed vulcanizing agent to the mixed system, continuously stirring for 5-20 minutes and then paving a film under panel glass and drying; finally, vulcanizing and furnace-cooling at 100-300 DEG C. The silicone rubber prepared by the method has the function of preventing intrauterine adhesion and accelerating the recovery of endometrium.

Description

technical field [0001] The invention relates to a preparation method of modified silicone rubber. Background technique [0002] Due to its excellent physical properties and biocompatibility, silicone rubber is inert, non-toxic, non-carcinogenic, and resistant to biological aging. It has minimal reaction to human tissue, does not cause foreign body reaction after implantation in human tissue, and does not cause inflammation to surrounding tissues. , which has been widely used in biomedicine. The applicant of the present invention applied the silicone rubber material to the intrauterine adhesion treatment device for the first time (Patent No. ZL200820052366.3). This device is the independent intellectual property owned by the applicant of the present invention. The device has its unique shape design. One is that its shape is completely consistent with the shape of the uterine cavity. This design can ensure that the shape of the uterine cavity after treatment can be maintain...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/16A61L31/06
Inventor 刘芳
Owner 刘芳
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