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A kind of bioactive multilayer composite ceramic microsphere material, preparation method and application

A composite ceramic and biologically active technology, applied in medical science, prostheses, etc., can solve problems such as long time for complete bone repair, insufficient coordination and matching of bone damage speed, and limited technical means, and achieve excellent biocompatibility, effective Favorable effect on cell migration

Active Publication Date: 2014-10-01
ZHEJIANG UNIV
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Problems solved by technology

Chinese patent ZL200610049179.5 uses layer-layer assembly technology to prepare a shell-core multilayer microstructure nanoparticle material with silica gel nanospheres as the core carrier, calcium phosphate as the shell, and multiple trace elements. The method solved the problem of synergistic assembly of multiple active substances for the first time, and achieved the excellent effect of synergistically controlled release of multiple trace elements. However, the technical means to independently control the degradation rate of the silica gel nanosphere particle carrier in the preparation method is still limited, so the material exists. Insufficient coordination between degradation process and bone damage rate
In the Chinese patent ZL200810121187.5, wet chemical technology was used to realize the preparation of calcium phosphate porous microspheres synergistically doped with multiple trace elements, but calcium phosphate gradually transformed into a more stable apatite phase in living bone tissue, so there was an early Faster repair but longer bone repair time due to reduced material degradation rate

Method used

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  • A kind of bioactive multilayer composite ceramic microsphere material, preparation method and application
  • A kind of bioactive multilayer composite ceramic microsphere material, preparation method and application
  • A kind of bioactive multilayer composite ceramic microsphere material, preparation method and application

Examples

Experimental program
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Embodiment 1

[0039] Example 1: [Composite ceramic microspheres with zinc-doped β-calcium silicate as the core layer and strontium-doped β-tricalcium phosphate as the shell layer]

[0040] 1) Add 500 mL of 0.275 mol / L CaCl 2 , 0.025 mol / L SrCl 2 The pH value of the aqueous solution was adjusted to 10.8, and then the solution was added dropwise to 0.2 mol / L (NH 4 ) 2 HPO 4 In the aqueous solution of inorganic salt, continue to stir for 30 minutes after the dropwise addition is completed, then filter the reaction deposit, wash with deionized water for 4 times, and then wash with absolute ethanol for 2 times, 80 o C drying, after 850 o C for 3 hours and ball milling for 3 hours to obtain strontium-doped β-tricalcium phosphate powder with a particle size of 2-6 μm. After X-ray diffraction test, the diffraction peaks of the obtained powder (such as figure 1 (shown) is consistent with the diffraction peak of β-tricalcium phosphate, indicating that the phase of the synthesized powder is β-t...

Embodiment 2

[0043] Example 2: [Composite ceramic microspheres with magnesium-doped β-tricalcium phosphate as the core layer and strontium-doped β-calcium silicate as the shell layer]

[0044] 1) Add 500 mL of 0.28 mol / L CaCl 2 , 0.08 mol / L MgCl 2 The pH value of the aqueous solution was adjusted to 10.6, and then the solution was added dropwise to 0.24 mol / L Na with a pH of 10.6 and a volume of 500 mL 2 HPO 4 2H 2 O in the aqueous inorganic salt solution, continue to stir for 45 minutes after the dropwise addition is completed, then filter the reaction deposit, wash with deionized water for 3 times, and then wash with absolute ethanol for 1 time, 80 o C drying, after 900 o C for 3 hours, and then ball milled for 4 hours to obtain a powder with a particle size of 2-6 μm. X-ray diffraction test proves that the phase of the powder is β-tricalcium phosphate. As tested by atomic absorption spectrometry, the magnesium content in the β-tricalcium phosphate powder is 8.34%.

[0045] 2) Add ...

Embodiment 3

[0047] Example 3: [Composite ceramic microspheres doped with strontium and magnesium β-tricalcium phosphate as the core layer and strontium and zinc doped α-calcium silicate as the shell layer]

[0048] 1) Add 500 mL of 0.30 mol / L CaCl 2 , 0.01 mol / L SrCl 2 , 0.05 mol / L MgCl 2 The pH value of the aqueous solution was adjusted to 10.6, and then the solution was added dropwise to 0.24 mol / L (NH 4 ) 2 HPO 4 In the aqueous solution of inorganic salt, continue to stir for 45 minutes after the dropwise addition is completed, then filter the reaction sediment, wash with deionized water for 3 times, and then wash with absolute ethanol for 1 time, 80 o C drying, after 850 o C for 3 hours, and then ball milled for 4 hours to obtain a powder with a particle size of 2-6 μm. X-ray diffraction test proves that the powder is β-tricalcium phosphate. The content of strontium and magnesium in the β-tricalcium phosphate powder is 1.46% and 5.84% respectively according to the analysis and t...

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Abstract

The invention discloses a bioactive multilayer multiphase ceramic microsphere material and its preparation method and use. The bioactive multilayer multiphase ceramic microsphere material comprises multilayer microspheres obtained by alternate wrapping of beta-tricalcium phosphate and calcium silicate respectively doped with foreign ions. The preparation method comprises the following steps of respectively dispersing the beta-tricalcium phosphate and calcium silicate powder respectively doped with the foreign ions into alginate hydrosol to obtain two types of paste, putting the two types of paste respectively into liquid storage tanks connected to two layers of coaxial tubular nozzles, synchronously injecting the paste in the liquid storage tanks to outlets of the two layers of coaxial tubular nozzles to obtain concentric multilayer paste liquid drops, and receiving the concentric multilayer paste liquid drops by an inorganic calcium salt aqueous solution, and carrying out drying and calcination. The bioactive multilayer multiphase ceramic microsphere material has the fast-slow alternative degradation rate characteristic in the normal liquid, and can release an inorganic ion composition with layer-by-layer degradation. Granularity, each-layer thickness and an inorganic ion release rate of the bioactive multilayer multiphase ceramic microsphere material can be controlled easily. The bioactive multilayer multiphase ceramic microsphere material can be used for bone defect repair and bone regeneration medical science.

Description

technical field [0001] The invention relates to biomedical materials, in particular to a bioactive multilayered composite ceramic microsphere material, a preparation method and an application. Background technique [0002] The rapid and complete regenerative repair of a series of bone injuries such as bone defect caused by mechanical force, bone loss and fracture caused by osteoporosis, bone tissue necrosis caused by tumor and inflammation is a difficult problem in clinical medicine at present. Professor Larry Hench first discovered a kind of CaO, SiO 2 ,P 2 o 5 and Na 2 The glass powder fired from the compound of the O component induces the deposition of bone-like apatite in the bone injury tissue, which can form a bone chemical bond with the living bone tissue, and develop into a bone repair material for clinical application (45S5 Bioglass?) . The discovery of this material has enabled people to gain a new understanding of the design of bioactive materials. So far, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/40A61L27/10C04B35/447C04B35/622
Inventor 苟中入杨贤燕陈晓怡杨永祝张峰
Owner ZHEJIANG UNIV
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