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Blood glucose reduction use of kardiseed dreg extractive

A technology of safflower seed meal and extract is applied in the field of hypoglycemic application of safflower seed meal extract, which can solve problems such as insulin resistance and the like

Inactive Publication Date: 2013-09-04
新疆宝康药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Taghi-biglou et al. carried human apolipoprotein B (ApoB 100 ) but lacked brown adipose tissue in apolipoprotein B (ApoB) / brown adipose tissue (BAT)-deficient mice and fructose-fed hamster models found that increased hepatic very low-density lipoprotein-apolipoprotein B would lead to Insulin resistance

Method used

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  • Blood glucose reduction use of kardiseed dreg extractive

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Take 200g of degreased safflower seed meal, pulverize it, put it in a 2L stoppered flask, put the flask into an ultrasonic extractor, and use 85% ethanol to ultrasonically extract at room temperature for 3 times, each time 1.5L, and each extraction time is 0.5 hours , combined extracts, filtered, concentrated to dryness in a rotary evaporator under reduced pressure, dissolved in water, and extracted with chloroform to obtain 10.7 g of safflower seed meal syrupy extract.

Embodiment 2

[0018] Take 800g of degreased safflower seed meal, pulverize it, put it in a 10L stoppered flask, put the flask into an ultrasonic extractor, and extract 3 times with 95% ethanol under reflux, each time 8L, each extraction time is 1 hour, and combine The extract was filtered, concentrated to dryness under reduced pressure in a rotary evaporator, dissolved in water, and extracted with chloroform to obtain 41.6 g of a syrupy extract of safflower seed meal.

Embodiment 3

[0020] Take 100g of degreased safflower seed meal, crush it, put it in a 1L stoppered flask, put the flask in a microwave oven, and use 95% ethanol for microwave-assisted extraction for 3 times, 0.6L each time, and each extraction time is 0.5 hours. liquid, filtered, concentrated to dryness under reduced pressure in a rotary evaporator, dissolved in water, and extracted with chloroform to obtain 15 g of safflower seed meal syrupy extract.

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Abstract

The invention relates to a blood glucose reduction use of a kardiseed dreg extractive, namely the use of the kardiseed dreg extractive in preparation of a drug for treating glycuresis, drug screening a target-protein-tyrosine-phosphatase 1B inhibitor, functional foods or medicine composition for treating glycuresis. The kardiseed dreg extractive mentioned in the invention is obtained by means of ethanol extraction and chloroform extraction, and simultaneously the effects of the protein-tyrosine-phosphatase 1B inhibitor of the kardiseed dreg extractive and the drugs, functional foods and medicine compositions formed by the kardiseed dreg extractive for treating glycuresis are proved externally.

Description

technical field [0001] The invention relates to a hypoglycemic application of safflower seed meal extract. Background technique [0002] Safflower is the dried flower of Carthamus tinctorius L. in Compositae, also known as grass safflower. The nature and flavor are pungent and warm, enter the heart and liver meridians, have the effects of promoting blood circulation and dredging menstruation, dispelling blood stasis and relieving pain. There are detailed records in the medical books of all dynasties and "Compendium of Materia Medica", and it is an important medicine for promoting blood circulation and removing blood stasis in traditional Chinese medicine. In ancient times, it was used as a drug to induce labor, and now it is mostly used to treat angina pectoris of coronary heart disease. [0003] Carthamus tinctorius L. is the seed of safflower (Carthamus tinctorius L.). Safflower meal is a by-product of extracting safflower oil from safflower seeds. Safflower originates...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/286A61P3/10A23L1/29A61K131/00A23L33/00
Inventor 信学雷阿吉艾克拜尔·艾萨
Owner 新疆宝康药业有限公司
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