Multi-sample stage with automatic movement for inverted microscope

Abstract

The invention relates to a multi-sample stage allowing for automatic movement of inverted microscopes. The multi-sample stage comprises a sample stage base and an objective lens. Screw supports are arranged on the sample stage base. A screw is arranged on the two screw supports through a coupling. The coupling is connected with a drive motor. A slide is arranged on the sample stage base. A sample cell moving rack is arranged on the slide. The top of the sample cell moving rack is screwed to the screw through a connector. A sample cell fixed rack is arranged on the sample stage base and is provided with a sample cell. The upper surface of the sample cell is made of a quartz glass slide, and the lower surface of the sample cell is made of a cover glass. The periphery of each of the quartz glass slide and the cover glass is sealed with epoxy resin. Space between the quartz slide glass and the cover glass is divided into a plurality of independent sample channels. The quartz glass slide is provided with through holes corresponding to the independent sample channels. The through holes are connected with an automatic sample feeder through sample guide tubes. The multi-sample stage is applicable to various inverted microscopes, is small in size, handy, flexible, and simple and fast to operate, and is an effective tool for the biological single-molecular study.

Description

technical field [0001] The invention belongs to the field of biological science experiments, and is a device for detecting and manipulating single molecules, in particular a multi-sample stage for automatic movement of an inverted microscope. Background technique [0002] Single-molecule technology refers to the real-time dynamic detection of the behavior of biological macromolecules (including conformational changes, interactions, mutual recognition, etc.) Single-molecule technology has the advantages of being direct, accurate, and real-time. By observing the behavior of single molecules such as single enzyme molecules and RNA / DNA molecules, we can study the elastic properties of nucleic acid molecules and the structural changes caused by external forces; The study of the special local environment of a single molecule, the fluctuation of molecules, the flexibility and motion of biomacromolecules has created favorable conditions and played a huge role in promoting the devel...

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to overcome the defect that the existing inverted microscope stage is not convenient for the sample to be observed to be replaced and focused in the focal plane of the microscope objective lens and cannot be equipped with multiple sample pools at the same time, and to invent a multi-sample inverted microscope that automatically moves Stage

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