Method for purifying polysaccharide iron complex based on ultrafiltration membrane method

Abstract

The present invention discloses a method for purifying polysaccharide iron complex, in particular to a method for desalination and concentration of the crude aqueous polysaccharide iron complex with the ultrafiltration membrane separation technology. Specific methods include the following steps of filtering the crude aqueous polysaccharide iron complex with ultrafiltration membrane components, whereby the pore diameter of ultrafiltration membrane components is between 2 and 50nm and molecular weight cutoff is between 5K and 150KDa; intercepting the polysaccharide iron complex by the ultrafiltration membrane, continuously discharging the sodium chloride and free iron ions in the crude aqueous solution through the osmotic solution to improve the purity and the concentration of polysaccharide iron complex in the ultrafiltration retentate liquid. The method for desalination and concentration of the crude aqueous polysaccharide iron complex with the ultrafiltration membrane provided by the invention has the following advantages of 1. simple operation process, safety and energy saving, mild condition and easy for continuous production; 2. reducing the salt concentration in the aqueous polysaccharide iron complex, and increasing the concentration of polysaccharide iron with recovery rate of more than 95%.

Description

[0001] technical field [0002] The invention relates to a purification method of a polysaccharide iron complex, in particular to a method for desalting and concentrating an aqueous solution of a polysaccharide iron complex crude product by using an ultrafiltration membrane separation technology. [0003] Background technique [0004] Polysaccharide iron complexes are a new generation of iron supplements. They not only have suitable complexation stability, but are less irritating to the gastrointestinal tract, and when iron is released, the polysaccharide itself has various biological activities and can be absorbed and utilized. The polysaccharide iron complex is composed of sugar base and glycoside iron. The sugar base can be dextran (dextran), chitosan, sucrose, plant polysaccharide, etc. Iron dextran and iron sucrose have been widely used clinically, and plant polysaccharide iron complexes with plant polysaccharides as ligands have become a hot spot for scholars and the ...

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Problems solved by technology

[0005] The purification of polysaccharide iron mainly uses the alcohol precipitation process to separate the salt in the polysaccharide iron complex aqueous solution, but this process is complex and has potential safety hazards, and the recovery of alcohol requires a large amount of steam, resulting in high production costs

Chinese patent CN101108194 discloses an electrodialysis device for the desalination of iron dextran complex aqueous solution, but because it is easy to cause the colloidal particles of iron dextran complex to agglomerate, resulting in pipeline blockage and membrane pollution, and the chlorine gas generated during the operation is easy to corrode device, affecting the industrial application of the method

Chinese patent CN101585887 discloses a method for desalting and concentrating an aqueous solution of iron dextran complexes using nanofiltration technology, but the method first uses a microfiltration membrane for pretreatment and then concentrates it with a nanofiltration membrane. The two-step membrane process leads to higher costs. At the same time, the nanofiltration membrane will intercept free iron ions, which affects the product purity to a certain extent, and the lower filtration flux of the nanofiltration membrane further increases the investment cost.

The present invention proposes to use ultrafiltration membrane to desalinate and concentrate the polysaccharide iron complex crude product aqueous solution, the process is simple, safe and energy-saving, and the conditions are mild. There is no similar report at home and abroad.

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