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Pretreatment method of traditional Chinese medicine

A technology of traditional Chinese medicine and scheme, applied in the field of natural medicine extraction and preparation, can solve the problems of insufficiency, poor sensitivity, low instrument response, etc., and achieve the effects of low price, good reproducibility and simple operation

Inactive Publication Date: 2013-07-24
曹君 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, in the analysis of the traditional Chinese medicine preparation Tanshinone Capsules, in the process of sample preparation, most of the medicinal materials are directly extracted from the ingredients and injected into the sample for analysis without any pretreatment steps, resulting in low response and poor sensitivity of the instrument when collecting data. Obviously, it can no longer meet people's requirements for the sample analysis method

Method used

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Examples

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Effect test

Embodiment 1

[0041] Example 1 is an investigation of the optimal enrichment time. The specific operation steps are as follows:

[0042] 1. Take an appropriate amount of reference substances of dihydrotanshinone, tanshinone I, cryptotanshinone, and tanshinone IIA, weigh them accurately, put them in a brown measuring bottle, and add methanol to prepare a solution containing 500 μg per 1 mL.

[0043] 2. Weigh 2 mg of hybrid mesoporous material PCMA-60, add 10 mL of water, weigh, and sonicate until a uniform white dispersion system is formed, take it out, let it stand, weigh again, make up the lost weight with water, and obtain nano-dispersion liquid.

[0044]3. Take six 50mL stoppered Erlenmeyer flasks numbered 1, 2, 3, 4, 5, and 6, and add 9mL of pure water, 1mL of hybrid mesoporous material PCMA-60 nano-dispersion, 5μL of dihydrogen Tanshinone, 10 μL tanshinone I, 5 μL cryptotanshinone, 5 μL tanshinone IIA and 975 μL pure water were weighed. And put 6 Erlenmeyer flasks with stoppers toge...

Embodiment 2

[0052] Example 2 Investigation of the instruments used for optimal enrichment. The specific experimental steps are as follows:

[0053] 1. Take an appropriate amount of reference substances of dihydrotanshinone, tanshinone I, cryptotanshinone, and tanshinone IIA, weigh them accurately, put them in a brown measuring bottle, and add methanol to prepare a solution containing 500 μg per 1 mL.

[0054] 2. Weigh 2 mg of hybrid mesoporous material PCMA-60, add 10 mL of water, weigh, and sonicate until a uniform white dispersion system is formed, take it out, let it stand, weigh again, make up the lost weight with water, and obtain nano-dispersion liquid.

[0055] 3. Take three 50mL stoppered Erlenmeyer flasks numbered 1, 2, and 3, and add 9mL of pure water, 1mL of hybrid mesoporous material PCMA-60 nano-dispersion, 5 μL of dihydrotanshinone, 10 μL of tanshinone I, 5 μL cryptotanshinone, 5 μL tanshinone II A and 975 μL pure water were weighed.

[0056] 4. Put the No. 1 stoppered Er...

Embodiment 3

[0064] The investigation of embodiment 3 optimal nano concentration. The specific experimental operation steps are:

[0065] 1. Take an appropriate amount of reference substances of dihydrotanshinone, tanshinone I, cryptotanshinone, and tanshinone IIA, weigh them accurately, put them in a brown measuring bottle, and add methanol to prepare a solution containing 500 μg per 1 mL.

[0066] 2. Weigh 2 mg of hybrid mesoporous material PCMA-60, add 10 mL of water, weigh, and sonicate until a uniform white dispersion system is formed, take it out, let it stand, weigh again, make up the lost weight with water, and obtain nano-dispersion liquid.

[0067] 3. Take four 50mL stoppered Erlenmeyer flasks numbered 1, 2, 3, and 4. Add 9.5mL of pure water, 0.5mL of hybrid mesoporous material PCMA-60 nano-dispersion, 5μL of Hydrotanshinone, 10 μL tanshinone I, 5 μL cryptotanshinone, 5 μL tanshinone IIA, and 975 μL pure water; add 9.0 mL pure water, 1.0 mL hybrid mesoporous material PCMA-60 na...

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Abstract

The invention discloses a pretreatment method of a traditional Chinese medicine. The pretreatment method is used for enriching diterpenoid quinine components in tanshinone capsules by using a nanometer dispersion solution, wherein the nanometer dispersion solution is a dispersion system of a hybrid mesoporous material Permanent Confined Micell Arrays-60. The treatment method has a remarkable enrichment effect and can be used for enriching the diterpenoid quinine components in the tanshinone capsules more effectively.

Description

technical field [0001] The invention relates to a pretreatment method of traditional Chinese medicine. Specifically, it involves using the nano-dispersion of the hybrid mesoporous material Permanent Confined Micell Arrays-60 (hereinafter referred to as PCMA-60) as an adsorbent in the pretreatment of traditional Chinese medicine samples to enrich the diterpene quinone components in tanshinone capsules , belongs to the field of extraction and preparation of natural medicines. Background technique [0002] Salvia miltiorrhiza is the dry root and rhizome of Salviamiltiorrhiza Bunge, which is used for irregular menstruation, wrist and hypochondriac pain, chest wall pain, and amenorrhea. The effect of cooling blood and eliminating carbuncle. It has been clinically proven that Danshen has the functions of dilating blood vessels, inhibiting platelet aggregation and antithrombosis, protecting myocardium, lowering blood fat and resisting atherosclerosis, increasing coronary flow, an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N1/40
Inventor 曹君胡帅帅刘晓娟
Owner 曹君
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