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Long-acting doxycycline hydrochloride injection for animals and preparation method thereof

A technology for doxycycline hydrochloride and injection, which is applied in the field of veterinary long-acting doxycycline hydrochloride injection and preparation thereof, tetracycline injection for veterinary use and preparation thereof, can solve the problems of expanding the antibacterial spectrum and the like, and achieve favorable Rehabilitation, cost saving, stress reduction effect

Inactive Publication Date: 2013-07-24
庞永中 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, CN101062014A discloses a kind of veterinary compound doxycycline hydrochloride injection and its preparation process, which is a compound preparation, and the purpose is to expand the antibacterial spectrum; CN 101301268A discloses a composition and preparation method of veterinary doxycycline hydrochloride injection The purpose of its preparation process is to solve the stability problem of the preparation, and none of them involves the problem of sustained release and long-term effect

Method used

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  • Long-acting doxycycline hydrochloride injection for animals and preparation method thereof
  • Long-acting doxycycline hydrochloride injection for animals and preparation method thereof
  • Long-acting doxycycline hydrochloride injection for animals and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0034] (1) Put 400ml of glycerol methylal, 300ml of α-pyrrolidone, and 100ml of propylene glycol into a glass batching container, heat to 50°C, add 50g of polyvinylpyrrolidone while stirring, and then add polyvinylpyrrolidone with a potency of 94.36 iu / mg while stirring. Doxycycline hydrochloride 53g, continue to stir for 20 minutes, make stirring evenly;

[0035] (2) Pass water to cool to 35°C; adjust the pH value to 3.0 with ethanolamine; then supplement with propylene glycol to the full volume of 1000ml.

[0036] (3) After filtering, filling and sealing in brown glass ampoules with nitrogen gas, steam sterilization at 100°C, lamp inspection, and printing, the long-acting doxycycline hydrochloride injection with a content of 5% was obtained.

Embodiment 2

[0038] (1) Put 300ml of glycerin methylal, 200ml of α-pyrrolidone, and 100ml of propylene glycol into a glass batching container, heat to 50°C, add 100g of polyvinylpyrrolidone while stirring, and then add polyvinylpyrrolidone with a potency of 94.36 iu / mg while stirring. Doxycycline hydrochloride 106g, continue to stir for 30 minutes, make stirring evenly;

[0039] (2) Pass water to cool to 35°C; adjust the pH value to 5.0 with ethanolamine; then supplement with propylene glycol to the full volume of 1000ml.

[0040] (3) After filtering, filling with nitrogen, filling and sealing in a brown glass ampoule, steam sterilization at 100°C, lamp inspection, and printing, the long-acting doxycycline hydrochloride injection with a content of 10% is obtained.

Embodiment 3

[0042] (1) Put 200ml of glycerol methylal, 100ml of α-pyrrolidone, and 200ml of propylene glycol into the batching tank, heat to 50°C, add 75g of polyvinylpyrrolidone while stirring, and then add hydrochloric acid with a potency of 94.36 iu / mg while stirring Doxycycline 265g, continue stirring for 25 minutes to make the stirring evenly;

[0043] (2) Pass water to cool to 35°C; adjust the pH value to 4.0 with ethanolamine; then supplement with propylene glycol to the full volume of 1000ml.

[0044] (3) After filtration, filled with nitrogen and sealed in a brown glass ampoule, sterilized by flowing steam at 100°C, inspected by light, and printed, the long-acting doxycycline hydrochloride injection with a content of 25% was obtained.

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Abstract

The invention relates to a long-acting doxycycline hydrochloride injection for animals and a preparation method thereof. The long-acting doxycycline hydrochloride injection for the animals mainly comprises a main drug doxycycline hydrochloride, compound solvents glycerol methylal, alpha-pyrrolidone and propylene glycol, a sustained-release agent polyvinylpyrrolidone K30-K17 and a pH value regulator ethanol amine or benzyl alcohol. The preparation method comprises the following concrete steps of putting glycerol methylal, alpha-pyrrolidone and a part of propylene glycol into a burdening tank, heating to 40-60 DEG C, stirring while adding polyvinylpyrrolidone, adding doxycycline hydrochloride during stirring, carrying out water cooling to 30-40 DEG C after fully and uniformly stirring, regulating the pH value to 3.0-5.0 by using ethanol amine or benzyl alcohol, replenishing to full dose by using propylene glycol, uniformly stirring, filtering, introducing nitrogen, pouring and sealing in a brown glass bottle, sterilizing by using flowing steam at the temperature of 100 DEG C, carrying out lamp inspection, printing and packing to obtain the long-acting doxycycline hydrochloride injection. The content of the injection is 1-40.0%; the injection has sustained-release and long-acting effects and is given once two days; and therefore, the labour and the cost are saved, the increased stress due to pig catching and injection giving is reduced and the recovery of sick pigs is benefited.

Description

Technical field [0001] The present invention involves a beast tetracycline injection and its preparation method. It specifically involves a long -acting long -acting polyxide injection and its preparation method for a beast, which is the field of veterinary drug preparation technology. Background technique [0002] Doxycycline hydrochloride, also known as oxygencin hydrochloride, is a semi -synthetic tetracycline antibiotic made of deoxycin, which is dehydrated.Salmonella, Paramia, and Smart Blossoms.5 ~ 10mg of pigs, once a day, 2 to 3 days (the third volume of the National Standard for Veteria Pharmaceuticals issued by the Veterinary Medicine Evaluation Center of the Ministry of Agriculture of the People's Republic of China in July 2012).In addition, the CN101062014A disclosed a kind of beast composite polyxide injection and its preparation process for compound preparations, the purpose is to expand the antibacterial spectrum; CN 101301268A disclosed the composition of a beast ...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/65A61K47/32A61P11/00A61P31/04
Inventor 庞永中庞雁
Owner 庞永中
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