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Application of pyrroloquinoline quinone (PQQ) in treatment and/or improvement of diabetic foot

A technology of diabetic foot and quinoline quinone, which is applied in the field of treatment of diabetes and/or diabetic complications, and can solve problems such as research on the prevention and treatment improvement of diabetic complications without PQQ active substances

Active Publication Date: 2013-07-10
SHANGHAIMED
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] However, prior to the present invention, no research has been done on PQQ active substances for the prevention, treatment and / or improvement of diabetes and / or diabetic complications

Method used

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  • Application of pyrroloquinoline quinone (PQQ) in treatment and/or improvement of diabetic foot
  • Application of pyrroloquinoline quinone (PQQ) in treatment and/or improvement of diabetic foot
  • Application of pyrroloquinoline quinone (PQQ) in treatment and/or improvement of diabetic foot

Examples

Experimental program
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Effect test

Embodiment

[0072] Below in conjunction with specific embodiment, further illustrate the present invention. It should be understood that these examples are only used to illustrate the present invention and are not intended to limit the scope of the present invention. The test methods for which specific conditions are not indicated in the following examples are usually in accordance with conventional conditions or in accordance with the conditions suggested by the manufacturer. Percentages and parts are by weight unless otherwise indicated.

[0073] Unless otherwise defined, all professional and scientific terms used herein have the same meanings as commonly understood by those skilled in the art. In addition, any methods and materials similar or equivalent to those described can also be applied in the present invention. The preferred implementation methods and materials described herein are for exemplary purposes only.

[0074] I. Experimental design

[0075] Experimental animals: SD ...

Embodiment 1

[0083] Example 1: The improvement effect of PQQ on diabetic foot symptoms

[0084] Two weeks after successful modeling, different degrees of acral gangrene appeared in both the DM model group and the PQQ treatment group. Observe and record the acral gangrene status of rats in each group before and after 4 weeks of PQQ treatment respectively. , 1996,4(2):126) for scoring.

[0085] Scoring criteria for acral gangrene: 1 point: no open lesion on the skin, and the color is black; 2 points: mild open lesion on the skin, blisters and blood blisters can be seen, but the lesion does not involve deep tissues; 3 points: the lesion has invaded deep muscles Tissues, infection, ulcers and more purulent secretions can be seen. Score the limbs of diabetic foot rats with the above three grades, and then calculate the total score for each rat.

[0086] Experimental results and analysis

[0087] Table 1 shows the comparison of acral gangrene between the control group and each experimental g...

Embodiment 2

[0094] Example 2: Effect of PQQ on the sciatic nerve of streptozotocin rats

[0095] 1. Determination of sciatic nerve conduction velocity: After PQQ treatment for 4 weeks, three rats were randomly selected from each group, anesthetized with 3% pentobarbital sodium, fixed in a 37°C constant temperature water bath, and measured by electric stimulation. conduction velocity. Place the stimulating electrode at the proximal end of the tail, insert the recording electrode at the distal end of the tail, near the lateral tail vein, place the reference electrode at the distal end of the mouse tail, about 2 cm away from the recording electrode, and place the grounding electrode between the stimulating electrode and the recording electrode . Use the Pclab-UE biomedical signal acquisition and processing system to give stimulation and record potential signals. Stimulate with a single pulse square wave, the wave width is 0.1ms, the stimulation intensity is 1.5 times the threshold, and the...

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PUM

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Abstract

The invention provides an application of a pyrroloquinoline quinone (PQQ) active substance in preparation of medicaments for treating and / or improving a diabetic complication, namely diabetic foot and further provides a health-care product composition or a pharmaceutical composition containing pyrroloquinoline quinone. The active substance, namely the pyrroloquinoline quinone in the composition provided by the invention has significant treatment and / improvement action against the diabetic complication, namely the diabetic foot by improving nerve conduction velocity, reducing sorbitol content, increasing the open number of capillaries, reducing whole blood viscosity, enhancing blood flow, increasing neural blood flow, promoting blood circulation, improving microcirculation of blood vessels and reducing gangrene ulcers of the foot. Therefore, the pyrroloquinoline quinone has great application prospects in prevention, treatment and / or improvement of occurrence and development of the diabetic complication, namely the diabetic foot.

Description

technical field [0001] The present invention relates to the field of treatment of diabetes and / or diabetic complications. More specifically, the present invention relates to the application of pyrroloquinoline quinone in treating, preventing and / or improving diabetes and / or diabetic complications in diabetic foot. Background technique [0002] Diabetes is a common endocrine system disease. It is caused by the absolute lack or relative deficiency of insulin in the body, or the quality of the substance itself and other reasons that can not play normal physiological functions, resulting in the metabolism of sugar, fat, A syndrome of disordered metabolism of the three major substances of protein. The main clinical manifestations of diabetes are polydipsia, polyuria, polyphagia, and weight loss ("three more and one less"), as well as high blood sugar and glucose in the urine. Diabetes is a lifelong disease that is difficult to cure, and diabetes can cause many complications, in...

Claims

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Application Information

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IPC IPC(8): A61K31/4745A61P3/10A61P17/02
Inventor 顾建新周蕾孙琳琳仵倩
Owner SHANGHAIMED
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