Preparation method of theophylline molecular surface printing material

Abstract

The invention discloses a preparation method of a theophylline molecular surface printing material, and relates to a molecular printing polymer. The preparation method comprises the following steps of: activating silica gel microparticles; connecting surface chemical bonds of silica gel microparticles with sulfydryl containing silane coupling agents; chemically grafting polyglycidyl methacrylate on surfaces of silica gel microparticles; modifying by 5-aminosalicylic acid; and preparing the surface molecular printing polymer of silica gel microparticles. According to the invention, high performance molecular printing polymer is prepared through a method of graft polymerization and crosslinking printing sequentially. The molecular surface printing material has special identifying selection and excellent combining affinity to theophylline.

Description

technical field [0001] The invention relates to molecularly imprinted polymers, in particular to a method for preparing theophylline molecular surface imprinted materials. Background technique [0002] Alkaloids are a large class of nitrogen-containing natural organic compounds, which are widely found in many kinds of plant tissues, most of which have complex nitrogen heterocyclic structures, and have significant physiological and pharmacological activities, such as anti-tumor, anti-inflammatory, anti-viral and other pharmaceutical functions. Alkaloids have very important application value and huge application potential in the field of medicine. With the rapid increase in the market demand for various alkaloids, scientifically and efficiently extracting, separating and purifying alkaloids from plants has become a concern. science and technology. [0003] At present, solvent extraction methods are generally used to extract alkaloids from plant tissues, such as ultrasonic-a...

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Problems solved by technology

[0005] The traditional method of preparing molecularly imprinted polymers is the embedding method, which has the following disadvantages: the obtained imprinted polymers are blocky, and the imprinting efficiency is not high; the process of crushing, grinding and sieving to obtain imprinted polymer particles, the flow complex; and many imprinted holes are destroyed, resulting in a limited number of imprinted holes in the particles, and the binding performance of template molecules (ions) is not high; Thick, the pores of the hole are deep, the diffusion resistance of template molecules is large, the mass transfer speed is slow, and it is not easy to combine with the recognition site

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