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Carvedilol transdermal controlled-release preparation for treating liver cirrhosis or liver fibrosis

A controlled-release preparation and transdermal technology, applied in the field of medicine

Inactive Publication Date: 2013-06-26
JIAXING FUTEJI BIOLOGICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, carvedilol transdermal controlled-release preparations can solve several problems in the treatment of liver cirrhosis with non-selective beta-receptor blockers that antagonize the activity of α1 receptors. It has not been reported by any literature at present, so it has cutting-edge innovations novelty and usefulness

Method used

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  • Carvedilol transdermal controlled-release preparation for treating liver cirrhosis or liver fibrosis
  • Carvedilol transdermal controlled-release preparation for treating liver cirrhosis or liver fibrosis
  • Carvedilol transdermal controlled-release preparation for treating liver cirrhosis or liver fibrosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] A certain amount of carvedilol was placed in a beaker and dissolved with an appropriate amount of dichloromethane. Place an appropriate amount of Bio PSA-7 pressure sensitive adhesive in another beaker and stir. Mix the two solutions together until homogeneous. The mixture is then placed on the release layer and dried. Finally, put it on the backing support layer, cut it into patches of different sizes, package it and store it in a ventilated and dry place at room temperature.

[0032] The ingredients are as follows:

[0033] Element 1A 1B 1C 1D 1E Carvedilol 3％ 3％ 3％ 3％ 3％ Bio PSA-74502 97％ 72％ 47％ 22％ 0 Bio PSA-74202 0 25％ 50％ 75％ 97％

[0034] Franz transdermal permeation instrument and Spectra / Por7MWCO1000-38mm film were used to detect the drug penetration efficiency. See the attached manual for the results figure 1

Embodiment 2

[0036] The method is the same as Example 1, and the composition is as follows:

[0037] Element 2B 2C 2D 2E Carvedilol 3％ 3％ 3％ 3％ Bio PSA-74202 72％ 47％ 22％ 0 Bio PSA-74302 25％ 50％ 75％ 97％

[0038] For the results of drug transdermal penetration efficiency, please refer to the appendix of the instructions. figure 2 :

Embodiment 3

[0040] The method is the same as Example 1, and the composition is as follows:

[0041] Element 3B 3C 3D Carvedilol 3％ 3％ 3％ Bio PSA-74502 72％ 47％ 22％ Bio PSA-74302 25％ 50％ 75％

[0042] For the results of drug transdermal penetration efficiency, please refer to the appendix of the instructions. image 3 :

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Abstract

The invention relates to a preparation method, a formula, a drug release characteristic and pharmacological activity of a carvedilol transdermal controlled-release preparation for treating liver cirrhosis or liver fibrosis. The carvedilol transdermal controlled-release preparation can be used for treating the diseases related to liver cirrhosis or liver fibrosis. The invention relates to the preparation of various semi-solid and liquid transdermal controlled-release preparations or dosage forms such as patch, cream, gel and salve, or other semi-solid preparations, suspension, emulsion or other liquid preparations. According to the invention, the preparation provided by the invention is used for treating, improving and preventing the liver cirrhosis or liver fibrosis and the diseases related to liver cirrhosis or liver fibrosis by use of the controlled-release or slow-release characteristic of the carvedilol transdermal preparation, and can be independently used or combined with other medicines for treating liver cirrhosis or liver fibrosis.

Description

technical field [0001] The invention relates to a semi-solid and liquid preparation for treating, improving and preventing liver cirrhosis or liver fibrosis, which belongs to the technical field of medicine. Background technique [0002] Cirrhosis and Liver Fibrosis [0003] Liver cirrhosis (hepatic cirrhosis) is a common clinical chronic progressive liver disease, which is diffuse liver damage caused by long-term or repeated effects of one or more etiologies. Liver cirrhosis is divided into post-hepatitic cirrhosis in terms of pathogenesis, and a small part is alcoholic cirrhosis and schistosome cirrhosis. Histopathologically, liver cirrhosis is caused by extensive liver cell necrosis, nodular regeneration of residual liver cells, connective tissue hyperplasia and fibrous septa formation, leading to structural destruction of liver lobules and formation of pseudolobules, and gradual deformation and hardening of the liver. In the early stage, there are no obvious symptoms d...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K9/06A61K9/10A61K9/107A61K9/00A61K31/403A61P1/16
Inventor 袁旭东张恒志惠峪
Owner JIAXING FUTEJI BIOLOGICAL TECH
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