Stabilizing method for external composition

A composition for external use and stabilization technology, applied in the directions of drug combination, cosmetics, pharmaceutical formulations, etc., can solve the problem of high cost of two-liquid container, and achieve the effects of simple stabilization and inhibition of content reduction

Inactive Publication Date: 2013-06-26
ROHTO PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] In order to solve this problem, it is also possible to use a two-component container, but the cost of the two-component container is high, so a technology that can commercialize a one-component container is desired

Method used

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  • Stabilizing method for external composition
  • Stabilizing method for external composition
  • Stabilizing method for external composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0193] Hereinafter, although an Example is given and this invention is demonstrated in more detail, this invention is not limited to these Examples.

[0194] Preparation of soybean protein hydrolyzate

[0195] 50 g of powdery isolated soybean protein (product name "PR-800", manufactured by Yamato Kasei Co., Ltd.) was dispersed in 2 L of distilled water, and the pH was adjusted to 8.0 with 0.1 N NaOH. 500 mg of thermolysin (derived from Bacillus thermoproteolyticus, product name "SAMOAZE PC10F", manufactured by Daiwa Kasei Co., Ltd.) was added, and decomposition was performed at 60° C. for 15 hours. After the reaction, boil at 100°C for 10 minutes to inactivate thermolysin. After natural cooling, 25 g of a filter aid (Radiolight 500, Showa Chemical Industry Co., Ltd.) was added, stirred, and then filtered. The obtained filtrate was concentrated to 500 mL under reduced pressure, and then freeze-dried to finally obtain 26 g of thermolysin hydrolyzate.

[0196] Determinatio...

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Abstract

The present invention provides a stabilizing method for an external composition, wherein ion exchange resin is added in the external composition. Used as the ion exchange resin, if positive ion exchange resin is used, the unstable compound due to existence of the compound selected from a group consisting of compound containing an amino group and amine can be stabilized. The compound can be compound having a carbonyl group, e.g., quinone.

Description

technical field [0001] The present invention relates to an external composition used as a cosmetic or a quasi-drug, and a method for stabilizing the external composition. Background technique [0002] Pyrroloquinoline quinone (hereinafter, sometimes abbreviated as "PQQ") exists widely in the biological world such as plants, animals, and microorganisms, and functions as a redox coenzyme necessary for energy acquisition. [0003] PQQ is known to have many physiological activities, and is expected to be used as an active ingredient of pharmaceuticals, quasi-drugs, cosmetics, and nutritional supplements. As such physiological activities, the action of removing active oxygen and free radicals, the action of promoting cell proliferation, the action of ultraviolet absorption, the action of promoting the production of nerve growth factors, the action of improving brain function, the action of hair growth, the action of improving color, and the action of inhibiting melanin are known....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/72A61K8/67A61K8/64A61K8/49A61K31/437A61K47/30A61Q19/08A61Q17/04A61Q7/00A61P39/06A61P17/00A61P17/14A61P25/00
Inventor 福岛一宏中井史郎竹内祐介
Owner ROHTO PHARM CO LTD
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