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Methods for treatment of nephrotic syndrome and related conditions

A technology for nephrotic syndrome and nephropathy, applied in metabolic diseases, drug combinations, skin diseases, etc., can solve problems such as complicating disease mechanism research

Active Publication Date: 2013-06-05
苏曼特 S 丘格
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Therapies designed to alleviate proteinuria, further complicating the study of disease mechanisms

Method used

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  • Methods for treatment of nephrotic syndrome and related conditions
  • Methods for treatment of nephrotic syndrome and related conditions
  • Methods for treatment of nephrotic syndrome and related conditions

Examples

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Embodiment Construction

[0042] In the following discussion, certain articles and methods will be described for background and introductory purposes. Nothing contained herein should be construed as an "admission" of prior art. Applicant expressly reserves the right, where appropriate, to demonstrate that the articles and methods mentioned herein do not constitute prior art, as permitted by applicable law.

[0043] During the study of nephrotic syndrome, it was found that Angptl4 secreted by podocytes induces proteinuria. More importantly, as described herein, circulating Angptl4 attenuates proteinuria in transgenic animal models. Increased Angptl4 levels have been observed in nephrotic syndromes such as MCD and MN, but increased circulating levels of Angptl4 have not been linked to the cause of nephrotic syndrome.

[0044] Although increased Angptl4 levels have been shown to treat nephrotic syndrome and reduce associated proteinuria, increased circulating Angptl4 has been observed to induce hyperlip...

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Abstract

The present disclosure provides a method for treating and / or preventing nephrotic syndrome, such as but not limited to MCD and MN, and conditions related to nephrotic syndrome, such as but not limited to, proteinuria and edema, as well as diabetic nephropathy, diabetes mellitus, lupus nephritis or primary glomerular disease. The present disclosure further provides methods for reducing proteinuria and other disease states as discussed herein. Such methods comprise the therapeutic delivery of an Angptl4 polypeptide or Angptl4 polypeptide derivative to a subject.

Description

[0001] Statement Regarding Federally Funded Research [0002] The Federal Government provided funding for the work described herein and the Government has certain rights in the invention. technical field [0003] The present disclosure relates to methods for the treatment and prevention of nephrotic syndrome and its associated conditions such as, but not limited to, proteinuria and edema. Background technique [0004] Nephrotic syndrome (NS) is a general term for loss of protein in the urine (proteinuria), hyperlipidemia (hypercholesterolemia and hypertriglyceridemia), and edema. Nephrotic syndrome involves pathological changes in cells in the kidney, such as podocytes. Proteinuria is defined as the presence of excess serum protein in the urine. Albuminuria (a specific type of proteinuria) is a pathological condition in which albumin is present in the urine. [0005] Podocytes (or visceral epithelial cells) are cells in the outer layer of the glomerular capillary loops of...

Claims

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Application Information

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IPC IPC(8): A61K38/16A61K38/17A61P3/10A61P3/00A61P17/00
CPCA61K38/16A61K38/17A61P3/00A61P3/10
Inventor 苏曼特·丘格
Owner 苏曼特 S 丘格
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